公开(公告)号：US20110118462A1

公开(公告)日：2011-05-19

申请号：US12621237

申请日：2009-11-18

申请人： Mao CHEN ,  Shaoxuan Zhu ,  Xuebin Liu ,  Lizhen Zheng ,  Liwei Lin ,  Shuwen Xu ,  Yuping Wang ,  Wei Yang ,  Yunfeng Li ,  Fang Ye ,  Xiaona Zhang

发明人： Mao CHEN ,  Shaoxuan Zhu ,  Xuebin Liu ,  Lizhen Zheng ,  Liwei Lin ,  Shuwen Xu ,  Yuping Wang ,  Wei Yang ,  Yunfeng Li ,  Fang Ye ,  Xiaona Zhang

IPC分类号： C07D501/16

CPC分类号： C07D501/36

摘要： The invention relates to N-heterocyclic substituent-containing antibiotics, their preparation, and their use. Disclosed are sodium and potassium salts of 7-(α-((N,N′-diisopropylamidino)thio)acetylamino)-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio)methyl) cephalosporanic acid as presented by the general structure (I), their preparation, and their use. The antibiotics of the invention can be used to treat diseases caused by Gram-positive or Gram-negative bacteria such as septicaemia, gastrointestinal tract infection, and urinary tract infection. They have increased half-life in blood and lowered toxicity. They can reduce the frequency of drug use and lower medical treatment costs. They have improved stability and can be stored at ambient temperatures. The method of the invention is simple, and it produces high purity products which can meet the requirements of clinical use.

摘要翻译： 本发明涉及含有N-杂环取代基的抗生素，其制备及其应用。 公开了7-（α - （（N，N'-二异丙基脒基）硫基）乙酰氨基）-3 - （（（1,2,5,6-四氢-2-甲基-5,6-二氧代 -1,2,4-三嗪-3-基）硫基）甲基）头孢烷酸，其总体结构（I），它们的制备及其用途。 本发明的抗生素可用于治疗由革兰氏阳性或革兰氏阴性菌引起的疾病，例如败血症，胃肠道感染和尿路感染。 它们增加了血液中的半衰期，降低了毒性。 它们可以减少使用药物的频率，降低医疗费用。 它们具有改善的稳定性并且可以在环境温度下储存。 本发明的方法简单，产生可满足临床用途要求的高纯度产品。

公开(公告)号：US20140128359A1

公开(公告)日：2014-05-08

申请号：US13667266

申请日：2012-11-02

申请人： Mao Chen ,  Shaoxuan Zhu ,  Xuebin Liu ,  Lizhen Zheng ,  Liwei Lin ,  Shuwen Xu ,  Yuping Wang ,  Wei Yang ,  Yunfeng Li ,  Fang Ye ,  Xiaona Zhang

发明人： Mao Chen ,  Shaoxuan Zhu ,  Xuebin Liu ,  Lizhen Zheng ,  Liwei Lin ,  Shuwen Xu ,  Yuping Wang ,  Wei Yang ,  Yunfeng Li ,  Fang Ye ,  Xiaona Zhang

IPC分类号： C07D501/36 ,  C07D501/04

CPC分类号： C07D501/36

摘要： The invention relates to N-heterocyclic substituent-containing antibiotics, their preparation, and their use. Disclosed are sodium and potassium salts of 7-(α-((N,N′-diisopropylamidino)thio)acetylamino)-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-diox o-1,2,4-triazin-3-yl)thio)methyl) cephalosporanic acid as presented by the general structure (I), their preparation, and their use. The antibiotics of the invention can be used to treat diseases caused by Gram-positive or Gram-negative bacteria such as septicaemia, gastrointestinal tract infection, and urinary tract infection. They have increased half-life in blood and lowered toxicity. They can reduce the frequency of drug use and lower medical treatment costs. They have improved stability and can be stored at ambient temperatures. The method of the invention is simple, and it produces high purity products which can meet the requirements of clinical use.

摘要翻译： 本发明涉及含有N-杂环取代基的抗生素，其制备及其应用。 公开了7-（α - （（N，N'-二异丙基脒基）硫基）乙酰氨基）-3 - （（（1,2,5,6-四氢-2-甲基-5,6-二氧杂） o-1,2,4-三嗪-3-基）硫基）甲基）头孢烷酸，其总体结构（I），它们的制备及其用途。 本发明的抗生素可用于治疗由革兰氏阳性或革兰氏阴性菌如败血病，胃肠道感染和尿路感染引起的疾病。 它们增加了血液中的半衰期，降低了毒性。 它们可以减少使用药物的频率，降低医疗费用。 它们具有改善的稳定性并且可以在环境温度下储存。 本发明的方法简单，产生可满足临床用途要求的高纯度产品。

公开(公告)号：US20130203754A1

公开(公告)日：2013-08-08

申请号：US13805967

申请日：2011-06-09

申请人： Rifang Yang ,  Yunfeng Li ,  Yongzhen Li ,  Nan Zhao ,  Liuhong Yun ,  Juanjuan Qin ,  Zhongyao Feng ,  Youzhi Zhang

发明人： Rifang Yang ,  Yunfeng Li ,  Yongzhen Li ,  Nan Zhao ,  Liuhong Yun ,  Juanjuan Qin ,  Zhongyao Feng ,  Youzhi Zhang

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： Disclosed are 2-arylimidazo[1,2-a]pyridine-3-acetamide derivatives represented by formula I, their tautomer, racemate or optical isomer, their pharmaceutically acceptable salt, or their solvates, wherein R1, R2, R3 and R4 are defined as in the specification. Preparation methods of said compounds and use of said compounds in treating and/or preventing central nervous system disease associated with TSPO functional disorder

摘要翻译： 公开了由式I表示的2-芳基咪唑并[1,2-a]吡啶-3-乙酰胺衍生物，其互变异构体，外消旋物或旋光异构体，其药学上可接受的盐或其溶剂合物，其中R1，R2，R3和R4定义 如说明书中所述。 所述化合物的制备方法和所述化合物在治疗和/或预防与TSPO功能障碍相关的中枢神经系统疾病中的用途

公开(公告)号：US08318772B2

公开(公告)日：2012-11-27

申请号：US13001379

申请日：2009-06-23

申请人： Bohua Zhong ,  Youzhi Zhang ,  Yanping Zhang ,  Rui Xue ,  Xinhua He ,  Yunfeng Li ,  Hongxia Chen ,  Nan Zhao ,  Meiying Li

发明人： Bohua Zhong ,  Youzhi Zhang ,  Yanping Zhang ,  Rui Xue ,  Xinhua He ,  Yunfeng Li ,  Hongxia Chen ,  Nan Zhao ,  Meiying Li

IPC分类号： A61K31/4535 ,  A61K31/4025 ,  A61K31/381 ,  A61K31/357 ,  A61K31/36 ,  C07D407/12 ,  C07D409/14 ,  C07D409/12

CPC分类号： C07D407/12 ,  C07D407/14 ,  C07D409/12 ,  C07D409/14

摘要： The present invention relates to a new amine compound or a pharmaceutically acceptable salt thereof, wherein the definitions of X, R1, R2 and n are given in the description, to a pharmaceutical composition containing the compound as active ingredient, and to use of the amine compound or its pharmaceutically acceptable salt for the manufacture of an anti-depressent drug.

摘要翻译： 本发明涉及一种新的胺化合物或其药学上可接受的盐，其中X，R 1，R 2和n的定义在说明书中给出含有该化合物作为活性成分的药物组合物，以及使用该胺 化合物或其药学上可接受的盐，用于制造抗抑郁药物。

公开(公告)号：US08224065B2

公开(公告)日：2012-07-17

申请号：US11971898

申请日：2008-01-09

申请人： Zygmunt Pizlo ,  Yunfeng Li ,  Robert M. Steinman

发明人： Zygmunt Pizlo ,  Yunfeng Li ,  Robert M. Steinman

IPC分类号： G06K9/00

CPC分类号： G06K9/20 ,  G06K2209/40 ,  G06T7/543

摘要： The present disclosure describes a system and method for transforming a two-dimensional image of an object into a three-dimensional representation, or model, that recreates the three-dimensional contour of the object. In one example, three pairs of symmetric points establish an initial relationship between the original image and a virtual image, then additional pairs of symmetric points in the original image are reconstructed. In each pair, a visible point and an occluded point are mapped into 3-space with a single free variable characterizing the mapping for all pairs. A value for the free variable is then selected to maximize compactness of the model, where compactness is defined as a function of the model's volume and its surface area. “Noise” correction derives from enforcing symmetry and selecting best-fitting polyhedra for the model. Alternative embodiments extend this to additional polyhedra, add image segmentation, use perspective, and generalize to asymmetric polyhedra and non-polyhedral objects.

摘要翻译： 本公开描述了一种用于将对象的二维图像变换为重建对象的三维轮廓的三维表示或模型的系统和方法。 在一个示例中，三对对称点建立原始图像和虚拟图像之间的初始关系，然后重建原始图像中的附加对对称点。 在每对中，可视点和闭塞点被映射到具有表征所有对的映射的单个自由变量的3空间中。 然后选择自由变量的值以最大化模型的紧凑性，其中紧凑度被定义为模型体积及其表面积的函数。 “噪声”修正来源于实现对称性，并为模型选择最佳拟合多面体。 替代实施例将其扩展到附加的多面体，添加图像分割，使用透视图，并将其推广到不对称多面体和非多面体对象。

公开(公告)号：US07350394B1

公开(公告)日：2008-04-01

申请号：US11292473

申请日：2005-12-02

申请人： William Flynn ,  Wei Guo ,  Mark Heimbaugh ,  Yunfeng Li

发明人： William Flynn ,  Wei Guo ,  Mark Heimbaugh ,  Yunfeng Li

IPC分类号： G01P21/00

CPC分类号： G01P15/0891 ,  G01P15/18 ,  G01P21/00 ,  G11B19/043

摘要： A method is provided for identifying offsets of accelerometers integrated into hard disk drives. More specifically, often, disk drives employ accelerometers that constantly monitor the acceleration felt by the disk drive. Once the accelerations are less than a predetermined threshold, a free fall event is identified and an actuator arm that is generally positioned above the disk is placed in a safe location prior to impact. Accelerometers must be calibrated prior to use such that their inherent errors are identified and factored into the algorithm that identifies free fall. The method provided herein allows for the 0 g offset to be monitored without having to reorient the device being tested, thus saving time and money.

摘要翻译： 提供了一种用于识别集成到硬盘驱动器中的加速度计的偏移的方法。 更具体地，磁盘驱动器经常使用加速度计，它们不断地监视磁盘驱动器感觉到的加速度。 一旦加速度小于预定阈值，则识别出自由落体事件，并且通常位于盘上方的致动器臂在冲击之前被放置在安全位置。 加速度计必须在使用之前进行校准，以便确定其固有误差并将其分解到识别自由落体的算法中。 本文提供的方法允许监测0g偏移量，而不必重新定向被测试的装置，从而节省时间和金钱。

公开(公告)号：US07286317B1

公开(公告)日：2007-10-23

申请号：US11112391

申请日：2005-04-22

申请人： Yunfeng Li ,  Yu Sun

发明人： Yunfeng Li ,  Yu Sun

IPC分类号： G11B5/596

CPC分类号： G11B5/59627

摘要： A disk drive includes a rotatable data storage disk, a transducer, an actuator, and a controller. The disk includes information and data tracks that are defined thereon. The transducer is configured to read the information from the disk. The actuator is configured to position the transducer relative to the data tracks. The controller is configured to measure timing between particular information on the disk, to estimate repeatable runout of the disk based on the measured timing, and to compensate for repeatable runout of the disk responsive to the estimated repeatable runout while positioning the transducer relative to a selected track.

摘要翻译： 磁盘驱动器包括可旋转数据存储盘，换能器，致动器和控制器。 磁盘包括在其上定义的信息和数据轨道。 传感器被配置为从盘读取信息。 致动器被配置成相对于数据轨道定位换能器。 控制器被配置为测量盘上的特定信息之间的定时，以基于测量的定时估计盘的可重复跳动，并且响应于估计的可重复跳动来补偿盘的可重复跳动，同时相对于所选择的定位 跟踪。

公开(公告)号：US09397345B2

公开(公告)日：2016-07-19

申请号：US13949875

申请日：2013-07-24

申请人： Yangchuan Xing ,  Kan Huang ,  Yunfeng Li

发明人： Yangchuan Xing ,  Kan Huang ,  Yunfeng Li

IPC分类号： H01M4/36 ,  H01M4/86 ,  H01M4/92 ,  H01M12/08 ,  H01M8/02

CPC分类号： H01M4/8657 ,  H01M4/8605 ,  H01M4/926 ,  H01M8/0234 ,  H01M8/0245 ,  H01M12/08 ,  Y02E60/128 ,  Y02E60/50

摘要： In various embodiments, the present disclosure provides a layered metal-air cathode for a metal-air battery. Generally, the layered metal-air cathode comprises an active catalyst layer, a transition layer bonded to the active catalyst layer, and a backing layer bonded to the transition layer such that the transition layer is disposed between the active catalyst layer and the backing layer.

摘要翻译： 在各种实施例中，本公开提供了金属 - 空气电池的层状金属 - 空气阴极。 通常，层状金属 - 空气阴极包括活性催化剂层，结合到活性催化剂层的过渡层和结合到过渡层的背衬层，使得过渡层设置在活性催化剂层和背衬层之间。

公开(公告)号：US07400468B2

公开(公告)日：2008-07-15

申请号：US11603370

申请日：2006-11-22

申请人： Chang-Ik Kang ,  Yunfeng Li ,  Bong-Jin Lee

发明人： Chang-Ik Kang ,  Yunfeng Li ,  Bong-Jin Lee

IPC分类号： G11B5/596

CPC分类号： G11B19/042

摘要： A hard disk drive with a circuit that provides a control signal to a voice coil motor to move a head across a disk. The disk drive includes a circuit that provides a control signal to the voice coil motor to move the head. The circuit also has a state predictor and an inversion filter that compute a vibration estimate used to detect a vibration in the drive. When a threshold vibration is detected a vibration estimate is combined with the control signal to compensate for the vibration. The circuit detects the vibration without the need for an accelerometer or other sensor.

摘要翻译： 具有电路的硬盘驱动器，其向音圈电机提供控制信号以将磁头移动到磁盘上。 磁盘驱动器包括向音圈电机提供控制信号以移动磁头的电路。 该电路还具有状态预测器和反演滤波器，其计算用于检测驱动器中的振动的振动估计。 当检测到阈值振动时，将振动估计与控制信号组合以补偿振动。 该电路检测振动，无需加速度计或其他传感器。

公开(公告)号：US20080166065A1

公开(公告)日：2008-07-10

申请号：US11971898

申请日：2008-01-09

申请人： Zygmunt Pizlo ,  Yunfeng Li ,  Robert M. Steinman

发明人： Zygmunt Pizlo ,  Yunfeng Li ,  Robert M. Steinman

IPC分类号： G06K9/36

CPC分类号： G06K9/20 ,  G06K2209/40 ,  G06T7/543

摘要： The present disclosure describes a system and method for transforming a two-dimensional image of an object into a three-dimensional representation, or model, that recreates the three-dimensional contour of the object. In one example, three pairs of symmetric points establish an initial relationship between the original image and a virtual image, then additional pairs of symmetric points in the original image are reconstructed. In each pair, a visible point and an occluded point are mapped into 3-space with a single free variable characterizing the mapping for all pairs. A value for the free variable is then selected to maximize compactness of the model, where compactness is defined as a function of the model's volume and its surface area. “Noise” correction derives from enforcing symmetry and selecting best-fitting polyhedra for the model. Alternative embodiments extend this to additional polyhedra, add image segmentation, use perspective, and generalize to asymmetric polyhedra and non-polyhedral objects.

摘要翻译： 本公开描述了一种用于将对象的二维图像变换为重建对象的三维轮廓的三维表示或模型的系统和方法。 在一个示例中，三对对称点建立原始图像和虚拟图像之间的初始关系，然后重建原始图像中的附加对对称点。 在每对中，可视点和闭塞点被映射到具有表征所有对的映射的单个自由变量的3空间中。 然后选择自由变量的值以最大化模型的紧凑性，其中紧凑度被定义为模型体积及其表面积的函数。 “噪声”修正来源于实现对称性，并为模型选择最佳拟合多面体。 替代实施例将其扩展到附加的多面体，添加图像分割，使用透视图，并将其推广到不对称多面体和非多面体对象。