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1.SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE 有权
标题翻译: 取代的吲哚基氨基酸衍生物作为HISTONE脱乙酰基酶的新型抑制剂公开(公告)号:US20090124646A1
公开(公告)日:2009-05-14
申请号:US11572563
申请日:2005-07-25
申请人: Marc Gustaaf Celine Verdonck , Patrick Rene Angibaud , Bruno Roux , Isabelle Noelle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
发明人: Marc Gustaaf Celine Verdonck , Patrick Rene Angibaud , Bruno Roux , Isabelle Noelle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
IPC分类号: A61K31/506 , C07D401/14
CPC分类号: A61K31/506 , A61K31/454 , A61K31/4545 , C07D401/14 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056
摘要: This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译: 本发明包括式(I)的新化合物,其中R1,R2,R3,X和Y具有定义的含义,具有组蛋白脱乙酰酶抑制酶活性; 其制剂,含有它们的组合物及其作为药物的用途。
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2.
公开(公告)号:US07709487B2
公开(公告)日:2010-05-04
申请号:US11668906
申请日:2007-01-30
申请人: Kristof Van Emelen , Janine Arts , Leo Jacobus Jozef Backx , Hans Louis Jos De Winter , Sven Franciscus Anna Van Brandt , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Isabelle Noelle Constance Pilatte , Virginie Sophie Poncelet , Alexey Borisovich Dyatkin , Jimmy Arnold Viviane Van heusden
发明人: Kristof Van Emelen , Janine Arts , Leo Jacobus Jozef Backx , Hans Louis Jos De Winter , Sven Franciscus Anna Van Brandt , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Isabelle Noelle Constance Pilatte , Virginie Sophie Poncelet , Alexey Borisovich Dyatkin , Jimmy Arnold Viviane Van heusden
IPC分类号: A61K31/506 , C07D403/04
CPC分类号: C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D207/277 , C07D207/28 , C07D211/14 , C07D211/58 , C07D213/78 , C07D213/81 , C07D213/82 , C07D217/02 , C07D217/04 , C07D217/16 , C07D233/90 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D261/10 , C07D295/155 , C07D295/22 , C07D295/26 , C07D307/68 , C07D307/79 , C07D333/34 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48 , G01N33/573 , G01N2333/91
摘要: This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译: 本发明包括式(I)的新化合物,其中n,m,t,R 1,R 2,R 3,R 4,L,Q,X,Y,Z具有定义的含义,具有组蛋白脱乙酰酶抑制酶活性; 其制剂,含有它们的组合物及其作为药物的用途。
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3.
公开(公告)号:US08865720B2
公开(公告)日:2014-10-21
申请号:US14053119
申请日:2013-10-14
申请人: Kristof Van Emelen , Janine Arts , Leo-Jacobus Jozef Backx , Hans Louis Jos De Winter , Sven Franciscus Anna Van Brandt , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Isabelle Noelle Constance Pilatte , Virginie Sophie Poncelet , Alexey Borisovich Dyatkin , Jimmy Arnold Viviane Van Heusden
发明人: Kristof Van Emelen , Janine Arts , Leo-Jacobus Jozef Backx , Hans Louis Jos De Winter , Sven Franciscus Anna Van Brandt , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Isabelle Noelle Constance Pilatte , Virginie Sophie Poncelet , Alexey Borisovich Dyatkin , Jimmy Arnold Viviane Van Heusden
IPC分类号: C07D207/28 , C07D409/04 , C07D213/82 , C07D233/90 , C07D413/14 , C07D307/79 , C07D213/81 , C07D243/08 , G01N33/573 , C07D333/34 , A61K31/495 , C07D295/22 , A61K45/06 , C07D241/24 , C07D403/04 , C07D239/42 , A61K31/496 , C07D241/04 , C07D295/26 , C07D207/277 , C07D261/10
CPC分类号: C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D207/277 , C07D207/28 , C07D211/14 , C07D211/58 , C07D213/78 , C07D213/81 , C07D213/82 , C07D217/02 , C07D217/04 , C07D217/16 , C07D233/90 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D261/10 , C07D295/155 , C07D295/22 , C07D295/26 , C07D307/68 , C07D307/79 , C07D333/34 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48 , G01N33/573 , G01N2333/91
摘要: This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译: 本发明包括式(I)的新化合物,其中n,m,t,R 1,R 2,R 3,R 4,L,Q,X,Y,Z具有定义的含义,具有组蛋白脱乙酰酶抑制酶活性; 其制剂,含有它们的组合物及其作为药物的用途。
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公开(公告)号:US08592441B2
公开(公告)日:2013-11-26
申请号:US13447636
申请日:2012-04-16
申请人: Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
发明人: Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
IPC分类号: C07D401/14 , C07D409/14 , A61K31/506
CPC分类号: A61K31/506 , A61K31/454 , A61K31/4545 , C07D401/14 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056
摘要: This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
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5.SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE 有权
标题翻译: 取代的吲哚基氨基酸衍生物作为HISTONE脱乙酰基酶的新型抑制剂公开(公告)号:US20120220615A1
公开(公告)日:2012-08-30
申请号:US13447636
申请日:2012-04-16
申请人: Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
发明人: Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
IPC分类号: C07D401/14 , A61P35/04 , C07D491/04 , A61K31/506
CPC分类号: A61K31/506 , A61K31/454 , A61K31/4545 , C07D401/14 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056
摘要: This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译: 本发明包括式(I)的新化合物,其中R1,R2,R3,X和Y具有定义的含义,具有组蛋白脱乙酰酶抑制酶活性; 其制剂,含有它们的组合物及其作为药物的用途。
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6.SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE 有权
标题翻译: 取代的吲哚基氨基酸衍生物作为HISTONE脱乙酰基酶的新型抑制剂公开(公告)号:US20110136841A1
公开(公告)日:2011-06-09
申请号:US13027793
申请日:2011-02-15
申请人: Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatee , Peter Ten Holte , Janine Arts , Kristof Van Emelen
发明人: Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatee , Peter Ten Holte , Janine Arts , Kristof Van Emelen
IPC分类号: A61K31/506 , A61P35/00 , A61P35/02
CPC分类号: A61K31/506 , A61K31/454 , A61K31/4545 , C07D401/14 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056
摘要: This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译: 本发明包括式(I)的新化合物,其中R1,R2,R3,X和Y具有定义的含义,具有组蛋白脱乙酰酶抑制酶活性; 其制剂,含有它们的组合物及其作为药物的用途。
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7.
公开(公告)号:US20130324568A1
公开(公告)日:2013-12-05
申请号:US13962523
申请日:2013-08-08
申请人: Marc Gustaaf Celine VERDONCK , Partick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
发明人: Marc Gustaaf Celine VERDONCK , Partick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
IPC分类号: C07D401/14 , C07D409/14 , C07D491/056 , C07D405/14
CPC分类号: A61K31/506 , A61K31/454 , A61K31/4545 , C07D401/14 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056
摘要: This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
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8.Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase 有权
标题翻译: 取代的吲哚基烷基氨基衍生物作为组蛋白脱乙酰酶的新型抑制剂公开(公告)号:US08524728B2
公开(公告)日:2013-09-03
申请号:US13027793
申请日:2011-02-15
申请人: Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
发明人: Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
IPC分类号: A61K31/506 , C07D401/14
CPC分类号: A61K31/506 , A61K31/454 , A61K31/4545 , C07D401/14 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056
摘要: This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译: 本发明包括式(I)的新化合物,其中R1,R2,R3,X和Y具有定义的含义,具有组蛋白脱乙酰酶抑制酶活性; 其制剂,含有它们的组合物及其作为药物的用途。
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9.Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase 有权
标题翻译: 取代的吲哚基烷基氨基衍生物作为组蛋白脱乙酰酶的新型抑制剂公开(公告)号:US08193205B2
公开(公告)日:2012-06-05
申请号:US11572563
申请日:2005-07-25
申请人: Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
发明人: Marc Gustaaf Celine Verdonck , Patrick René Angibaud , Bruno Roux , Isabelle Noëlle Constance Pilatte , Peter Ten Holte , Janine Arts , Kristof Van Emelen
IPC分类号: C07D401/14 , C07D409/14 , A61K31/506
CPC分类号: A61K31/506 , A61K31/454 , A61K31/4545 , C07D401/14 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056
摘要: This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译: 本发明包括式(I)的新化合物,其中R1,R2,R3,X和Y具有定义的含义,具有组蛋白脱乙酰酶抑制酶活性; 其制剂,含有它们的组合物及其作为药物的用途。
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10.
公开(公告)号:US07704998B2
公开(公告)日:2010-04-27
申请号:US11926759
申请日:2007-10-29
申请人: Kristof Van Emelen , Janine Arts , Leo-Jacobus Jozef Backx , Hans Louis Jos De Winter , Sven Franciscus Anna Van Brandt , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Isabelle Noelle Constance Pilatte , Virginie Sophie Poncelet , Alexey Borisovich Dyatkin , Jimmy Arnold Viviane Van heusden
发明人: Kristof Van Emelen , Janine Arts , Leo-Jacobus Jozef Backx , Hans Louis Jos De Winter , Sven Franciscus Anna Van Brandt , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Isabelle Noelle Constance Pilatte , Virginie Sophie Poncelet , Alexey Borisovich Dyatkin , Jimmy Arnold Viviane Van heusden
IPC分类号: A61K31/551 , A61K31/495 , C07D241/04 , C07D403/04 , C07D413/14
CPC分类号: C07D413/12 , A61K31/40 , A61K31/402 , A61K31/435 , A61K31/4427 , A61K31/454 , A61K31/4545 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D207/09 , C07D207/14 , C07D207/277 , C07D207/28 , C07D211/14 , C07D211/58 , C07D213/78 , C07D213/81 , C07D213/82 , C07D217/02 , C07D217/04 , C07D217/16 , C07D233/90 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D261/10 , C07D295/155 , C07D295/22 , C07D295/26 , C07D307/68 , C07D307/79 , C07D333/34 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D471/10 , C07D513/04 , C12Q1/34 , C12Q1/48 , G01N33/573 , G01N2333/91
摘要: This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
摘要翻译: 本发明包括式(I)的新化合物,其中n,m,t,R 1,R 2,R 3,R 4,L,Q,X,Y,Z具有定义的含义,具有组蛋白脱乙酰酶抑制酶活性; 其制剂,含有它们的组合物及其作为药物的用途。
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