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公开(公告)号：US20120214966A1
公开(公告)日：2012-08-23
申请号：US13448959
申请日：2012-04-17
申请人： Marc-André Theoleyre , Stanislas Baudouin , Annick Merrien , Eric Valery , Olivier Ludemann-Hombourger , David Laurent , Margit Holzer
发明人： Marc-André Theoleyre , Stanislas Baudouin , Annick Merrien , Eric Valery , Olivier Ludemann-Hombourger , David Laurent , Margit Holzer
CPC分类号： B01D15/1871 , B01D15/1828 , B01D15/361 , B01D15/3804
摘要： A process is disclosed for separating biomolecules from an aqueous solution containing the biomolecules and impurities, having different affinities and/or interactions with a solid support. The solution is passed over a fixed bed of chromatographic resin containing at least three zones, with flow of liquid being arranged between adjacent zones and between a last and first zone. Each of several sequences includes at least an adsorption stage, a rinsing stage, or a desorption stage, with each subsequent sequence being carried out by a downstream displacement of fronts in the zones by approximately the same increment before the periodical displacement of the introduction and withdrawal points.
摘要翻译： 公开了一种从含有生物分子和杂质的水溶液中分离生物分子的方法，其与固体支持物具有不同的亲和力和/或相互作用。 该溶液通过含有至少三个区域的固定床层析树脂，其中液体流被布置在相邻区域之间并且在最后和第一区域之间。 几个序列中的每一个至少包括吸附阶段，漂洗阶段或解吸阶段，每个随后的顺序通过在引入和撤出的周期性位移之前在区域中的前沿的下游位移大致相同的增量来执行 积分
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公开(公告)号：US08465649B2
公开(公告)日：2013-06-18
申请号：US13448959
申请日：2012-04-17
申请人： Marc-André Theoleyre , Stanislas Baudouin , Annick Merrien , Eric Valery , Olivier Ludemann-Hombourger , David Laurent , Margit Holzer
发明人： Marc-André Theoleyre , Stanislas Baudouin , Annick Merrien , Eric Valery , Olivier Ludemann-Hombourger , David Laurent , Margit Holzer
IPC分类号： B01D15/08
CPC分类号： B01D15/1871 , B01D15/1828 , B01D15/361 , B01D15/3804
摘要： A process is disclosed for separating biomolecules from an aqueous solution containing the biomolectules and impurities, having different affinities and/or interactions with a solid support. The solution is passed over a fixed bed of chromatographic resin containing at least three zones, with flow of liquid being arranged between adjacent zones and between a last and first zone. Each of several sequences includes at least an adsorption stage, a rinsing stage, or a desorption stage, with each subsequent sequence being carried out by a downstream displacement of fronts in the zones by approximately the same increment before the periodical displacement of the introduction and withdrawal points.
摘要翻译： 公开了一种从含有生物电解质和杂质的水溶液中分离生物分子的方法，其具有与固体支持物的不同亲和力和/或相互作用。 该溶液通过含有至少三个区域的固定床层析树脂，其中液体流被布置在相邻区域之间并且在最后和第一区域之间。 几个序列中的每一个至少包括吸附阶段，漂洗阶段或解吸阶段，每个随后的顺序通过在引入和撤出的周期性位移之前在区域中的前沿的下游位移大致相同的增量来执行 积分
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公开(公告)号：US08182696B2
公开(公告)日：2012-05-22
申请号：US12304840
申请日：2007-06-18
申请人： Marc-André Theoleyre , Stanislas Baudouin , Annick Merrien , Eric Valery , Olivier Ludemann-Hombourger , David Laurent , Margit Holzer
发明人： Marc-André Theoleyre , Stanislas Baudouin , Annick Merrien , Eric Valery , Olivier Ludemann-Hombourger , David Laurent , Margit Holzer
IPC分类号： B01D15/08
CPC分类号： B01D15/1871 , B01D15/1828 , B01D15/361 , B01D15/3804
摘要： A process is disclosed for separating biomolecules from an aqueous solution containing the biomolectules and impurities, having different affinities and/or interactions with a solid support. The solution is passed over a fixed bed of chromatographic resin containing at least three zones, with flow of liquid being arranged between adjacent zones and between a last and first zone. Each of several sequences includes at least an adsorption stage, a rinsing stage, or a desorption stage, with each subsequent sequence being carried out by a downstream displacement of fronts in the zones by approximately the same increment before the periodical displacement of the introduction and withdrawal points.
摘要翻译： 公开了一种从含有生物电解质和杂质的水溶液中分离生物分子的方法，其具有与固体支持物的不同亲和力和/或相互作用。 该溶液通过含有至少三个区域的固定床层析树脂，其中液体流被布置在相邻区域之间并且在最后和第一区域之间。 几个序列中的每一个至少包括吸附阶段，漂洗阶段或解吸阶段，每个随后的顺序通过在引入和撤出的周期性位移之前在区域中的前沿的下游位移大致相同的增量来执行 积分
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4.发明申请Method And Device For Tracking The Degradation Of Insulators In A Rotary Machine 有权用于跟踪旋转机中绝缘子降解的方法和装置公开(公告)号：US20110203276A1
公开(公告)日：2011-08-25
申请号：US13062609
申请日：2009-09-03
申请人： Gérard Friedrich , Marie Jaillet-Delclaud , Emilie Renouard-Mouren , David Laurent , Bernard Mineur , Emmanuel Odic
发明人： Gérard Friedrich , Marie Jaillet-Delclaud , Emilie Renouard-Mouren , David Laurent , Bernard Mineur , Emmanuel Odic
CPC分类号： H02K11/20 , Y10T29/49002
摘要： A method for tracking the deterioration of the insulators in a rotating machine, a method for preventive maintenance of these machines using this tracking and devices using the tracking method is presented.
摘要翻译： 提出了一种用于跟踪旋转机器中的绝缘体的劣化的方法，使用该跟踪的这些机器的预防性维护方法和使用跟踪方法的装置。
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公开(公告)号：US20080153799A1
公开(公告)日：2008-06-26
申请号：US10597896
申请日：2005-02-07
IPC分类号： A61K31/397 , C07D215/00 , A61K31/47 , C07D295/00 , C07D217/00 , A61P37/00 , A61K31/5377 , A61K31/541 , A61K31/496
CPC分类号： C07D409/12 , C07D215/54 , C07D401/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to novel compounds which are JAK3 Kinase inhibitors, methods for their preparation and pharmaceutical compositions comprising them. A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein X is —CHOH or —C═O;
摘要翻译： 本发明涉及作为JAK3激酶抑制剂的新化合物，其制备方法和包含它们的药物组合物。 式（I）化合物或其药学上可接受的盐或溶剂合物，其中X为-CHOH或-C-O;
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6.发明授权Method and device for tracking the degradation of insulators in a rotary machine 有权用于跟踪旋转机器中绝缘子劣化的方法和装置公开(公告)号：US08766645B2
公开(公告)日：2014-07-01
申请号：US13062609
申请日：2009-09-03
申请人： Gérard Friedrich , Marie Jaillet-Delclaud , Emilie Renouard-Mouren , David Laurent , Bernard Mineur , Emmanuel Odic
发明人： Gérard Friedrich , Marie Jaillet-Delclaud , Emilie Renouard-Mouren , David Laurent , Bernard Mineur , Emmanuel Odic
CPC分类号： H02K11/20 , Y10T29/49002
摘要： A method for tracking the deterioration of the insulators in a rotating machine, a method for preventive maintenance of these machines using this tracking and devices using the tracking method is presented.
摘要翻译： 提出了一种用于跟踪旋转机器中的绝缘体的劣化的方法，使用该跟踪的这些机器的预防性维护方法和使用跟踪方法的装置。
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