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公开(公告)号：US07507836B2
公开(公告)日：2009-03-24
申请号：US10550968
申请日：2004-03-22
IPC分类号： C07D209/48 , C07C233/05 , A61K31/40 , A61K31/165
CPC分类号： C07D417/12 , C07D209/48 , C07D213/81 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D513/04
摘要： The present invention is directed to compounds which are allosteric modulators of metabotropic glutamate receptors, including the mGluR5 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
摘要翻译： 本发明涉及代谢型谷氨酸受体的变构调节剂（包括mGluR5受体）的化合物，它们可用于治疗或预防与谷氨酸能力障碍相关的神经和精神疾病以及涉及代谢型谷氨酸受体的疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及代谢型谷氨酸受体的疾病中的用途。
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公开(公告)号：US07825135B2
公开(公告)日：2010-11-02
申请号：US10593950
申请日：2005-03-23
申请人： Wesley Blackaby , Mark E. Duggan , David Hallett , George D. Hartman , Andrew S. Jennings , William H. Leister , Richard T. Lewis , Craig W. Lindsley , Elizabeth Naylor , Leslie J. Street , Yi Wang , David D. Wisnoski , Scott E. Wolkenberg , Zhijian Zhao
发明人： Wesley Blackaby , Mark E. Duggan , David Hallett , George D. Hartman , Andrew S. Jennings , William H. Leister , Richard T. Lewis , Craig W. Lindsley , Elizabeth Naylor , Leslie J. Street , Yi Wang , David D. Wisnoski , Scott E. Wolkenberg , Zhijian Zhao
IPC分类号： A61K31/435 , A61K31/445
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D413/14
摘要： The present invention is directed to pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunction and diseases in which the glycine transporter GlyT1 is involved.
摘要翻译： 本发明涉及抑制甘氨酸转运蛋白GlyT1的吡啶基，哒嗪基，嘧啶基和吡嗪基哌啶化合物，其可用于治疗与甘氨酸能或谷氨酸能神经传递功能障碍相关的神经和精神疾病以及其中涉及甘氨酸转运蛋白GlyT1的疾病 。
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公开(公告)号：US07776886B2
公开(公告)日：2010-08-17
申请号：US11664190
申请日：2005-09-26
IPC分类号： A61K31/445 , C07D211/96
CPC分类号： C07D211/96
摘要： The present invention is directed to cyclopropyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neuro-transmission dysfunction and diseases in which the glycine transporter GlyT1 is involved.
摘要翻译： 本发明涉及抑制甘氨酸转运蛋白GlyT1的环丙基哌啶化合物，其可用于治疗与甘氨酸能或谷氨酸能神经传递功能障碍相关的神经和精神疾病以及其中涉及甘氨酸转运蛋白GlyT1的疾病。
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4.发明授权Synthesis of functional polymers for use in organic synthesis and combinatorial chemistry 失效用于有机合成和组合化学的功能聚合物的合成公开(公告)号：US07592392B2
公开(公告)日：2009-09-22
申请号：US10551011
申请日：2004-03-31
IPC分类号： C08L51/04 , C08F255/08 , C08F257/02 , C08F287/00
CPC分类号： C08F255/02 , C08F212/08 , C08F257/02 , C08F259/08 , C08F291/18 , C08F293/005 , C08F2/46
摘要： The present invention relates to a novel process for the preparation of solid-supported scavenging reagents and solid-supported functional polymers. The invention further relates to novel solid-supported functional polymers and to their use in organic synthesis and combinatorial chemistry.
摘要翻译： 本发明涉及一种制备固体支持的清除剂和固体支持的官能聚合物的新方法。 本发明还涉及新颖的固体支持官能聚合物及其在有机合成和组合化学中的应用。
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公开(公告)号：US20080108663A1
公开(公告)日：2008-05-08
申请号：US11664190
申请日：2005-09-26
IPC分类号： C07D211/96 , A61K31/445 , A61P25/00 , A61P25/18
CPC分类号： C07D211/96
摘要： The present invention is directed to cyclopropyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neuro-transmission dysfunction and diseases in which the glycine transporter GlyT1 is involved.
摘要翻译： 本发明涉及抑制甘氨酸转运蛋白GlyT1的环丙基哌啶化合物，其可用于治疗与甘氨酸能或谷氨酸能神经传递功能障碍相关的神经和精神疾病以及其中涉及甘氨酸转运蛋白GlyT1的疾病。
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6.发明授权(Halo-benzo carbonyl)heterocyclo fused phenyl p38 kinase inhibiting agents 失效（卤 - 苯并羰基）杂环稠合苯基p38激酶抑制剂公开(公告)号：US06809199B2
公开(公告)日：2004-10-26
申请号：US10023231
申请日：2001-12-17
申请人： James B. Doherty , John E. Stelmach , Meng-Hsin Chen , Luping Liu , Julianne A. Hunt , Rowena D. Ruzck , Joung L. Goulet , David D. Wisnoski , Swaminathan Ravi Natarajan , Kathleen M. Rupprecht , Jianming Bao , Shouwu Miao , Xingfang Hong , Peter J. Sinclair , Florida Kallashi
发明人： James B. Doherty , John E. Stelmach , Meng-Hsin Chen , Luping Liu , Julianne A. Hunt , Rowena D. Ruzck , Joung L. Goulet , David D. Wisnoski , Swaminathan Ravi Natarajan , Kathleen M. Rupprecht , Jianming Bao , Shouwu Miao , Xingfang Hong , Peter J. Sinclair , Florida Kallashi
IPC分类号： C07D23972
CPC分类号： C07D215/227 , C07D221/06 , C07D231/12 , C07D233/56 , C07D239/80 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/14 , C07D417/12 , C07D451/02 , C07D471/04 , C07D487/08
摘要： Compounds described by the chemical formula (I) or a pharmaceutically acceptable salt thereof: are inhibitors of p38 useful in the treatment of inflammatory diseases such as arthritis.
摘要翻译： 由化学式（I）表示的化合物或其药学上可接受的盐是可用于治疗炎性疾病如关节炎的p38的抑制剂。
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