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公开(公告)号:US07790770B2
公开(公告)日:2010-09-07
申请号:US11558979
申请日:2006-11-13
申请人: Mark E. Salvati , Heather Finlay , Lalgudi S. Harikrishnan , Ji Jiang , James A. Johnson , Muthoni G. Kamau , R. Michael Lawrence , John Lloyd , Michael M. Miller , Zulan Pi , Jennifer X. Qiao , Richard A. Rampulla , Jacques Y. Roberge , Tammy C. Wang , Yufeng Wang , Wu Yang
发明人: Mark E. Salvati , Heather Finlay , Lalgudi S. Harikrishnan , Ji Jiang , James A. Johnson , Muthoni G. Kamau , R. Michael Lawrence , John Lloyd , Michael M. Miller , Zulan Pi , Jennifer X. Qiao , Richard A. Rampulla , Jacques Y. Roberge , Tammy C. Wang , Yufeng Wang , Wu Yang
IPC分类号: A61K31/164 , C07C233/64
CPC分类号: C07C275/26 , C07C211/29 , C07C215/08 , C07C217/58 , C07C229/36 , C07C229/38 , C07C233/09 , C07C233/13 , C07C233/18 , C07C233/56 , C07C233/60 , C07C233/66 , C07C233/73 , C07C233/78 , C07C235/20 , C07C235/34 , C07C235/48 , C07C235/74 , C07C237/06 , C07C237/08 , C07C251/38 , C07C255/13 , C07C255/57 , C07C255/60 , C07C271/16 , C07C271/20 , C07C271/44 , C07C275/24 , C07C311/04 , C07C311/17 , C07C317/44 , C07C323/57 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/08 , C07D207/10 , C07D207/16 , C07D207/26 , C07D207/273 , C07D207/325 , C07D207/38 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/48 , C07D211/38 , C07D211/58 , C07D213/38 , C07D213/40 , C07D213/82 , C07D231/14 , C07D231/40 , C07D239/26 , C07D249/04 , C07D249/06 , C07D249/08 , C07D249/14 , C07D257/04 , C07D257/06 , C07D261/04 , C07D261/08 , C07D261/14 , C07D261/18 , C07D263/34 , C07D271/06 , C07D271/10 , C07D271/113 , C07D277/48 , C07D277/58 , C07D277/60 , C07D285/06 , C07D285/135 , C07D295/155 , C07D303/48 , C07D307/22 , C07D307/24 , C07D307/33 , C07D307/68 , C07D307/79 , C07D307/85 , C07D311/58 , C07D317/46 , C07D319/20 , C07D333/20 , C07D333/24 , C07D333/38 , C07D333/68 , C07D333/70 , C07D471/04 , C07F7/081
摘要: Compounds of formula Ia and Ib wherein A, B, C and R1 are described herein.
摘要翻译: 其中A,B,C和R 1的化合物在此描述。
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公开(公告)号:US20100267669A1
公开(公告)日:2010-10-21
申请号:US12797760
申请日:2010-06-10
申请人: Mark E. Salvati , Heather Finlay , Bang-Chi Chen , Lalgudi S. Harikrishnan , Ji Jiang , James A. Johnson , Muthoni G. Kamau , R. Michael Lawrence , Jianqing Li , John Lloyd , Michael M. Miller , Zulan Pi , Jennifer X. Qiao , Richard A. Rampulla , Jacques Y. Roberge , Tammy C. Wang , Yufeng Wang , Wu Yang
发明人: Mark E. Salvati , Heather Finlay , Bang-Chi Chen , Lalgudi S. Harikrishnan , Ji Jiang , James A. Johnson , Muthoni G. Kamau , R. Michael Lawrence , Jianqing Li , John Lloyd , Michael M. Miller , Zulan Pi , Jennifer X. Qiao , Richard A. Rampulla , Jacques Y. Roberge , Tammy C. Wang , Yufeng Wang , Wu Yang
IPC分类号: A61K31/695 , C07C273/00 , A61K31/17 , C07C233/00 , A61K31/165 , C07D277/20 , A61K31/426 , C07D211/98 , A61K31/4468 , C07D239/02 , A61K31/50 , C07D205/08 , C07D265/30 , A61K31/535 , A61P25/28 , A61P7/00 , A61P3/04 , A61P7/12 , A61P9/00
CPC分类号: C07C275/26 , C07C211/29 , C07C215/08 , C07C217/58 , C07C229/36 , C07C229/38 , C07C233/09 , C07C233/13 , C07C233/18 , C07C233/56 , C07C233/60 , C07C233/66 , C07C233/73 , C07C233/78 , C07C235/20 , C07C235/34 , C07C235/48 , C07C235/74 , C07C237/06 , C07C237/08 , C07C251/38 , C07C255/13 , C07C255/57 , C07C255/60 , C07C271/16 , C07C271/20 , C07C271/44 , C07C275/24 , C07C311/04 , C07C311/17 , C07C317/44 , C07C323/57 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/08 , C07D207/10 , C07D207/16 , C07D207/26 , C07D207/273 , C07D207/325 , C07D207/38 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/48 , C07D211/38 , C07D211/58 , C07D213/38 , C07D213/40 , C07D213/82 , C07D231/14 , C07D231/40 , C07D239/26 , C07D249/04 , C07D249/06 , C07D249/08 , C07D249/14 , C07D257/04 , C07D257/06 , C07D261/04 , C07D261/08 , C07D261/14 , C07D261/18 , C07D263/34 , C07D271/06 , C07D271/10 , C07D271/113 , C07D277/48 , C07D277/58 , C07D277/60 , C07D285/06 , C07D285/135 , C07D295/155 , C07D303/48 , C07D307/22 , C07D307/24 , C07D307/33 , C07D307/68 , C07D307/79 , C07D307/85 , C07D311/58 , C07D317/46 , C07D319/20 , C07D333/20 , C07D333/24 , C07D333/38 , C07D333/68 , C07D333/70 , C07D471/04 , C07F7/081
摘要: Compounds of formula Ia and Ib wherein A, B, C and R1 are described herein.
摘要翻译: 其中A,B,C和R 1的化合物在此描述。
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公开(公告)号:US08642576B2
公开(公告)日:2014-02-04
申请号:US13597364
申请日:2012-08-29
申请人: Mark E. Salvati , Heather Finlay , Bang-Chi Chen , Lalgudi S. Harikrishnan , Ji Jiang , James A. Johnson , Muthoni G. Kamau , R. Michael Lawrence , Jianqing Li , John Lloyd , Michael M. Miller , Zulan Pi , Jennifer X. Qiao , Richard A. Rampulla , Jacques Y. Roberge , Tammy C. Wang , Yufeng Wang , Wu Yang
发明人: Mark E. Salvati , Heather Finlay , Bang-Chi Chen , Lalgudi S. Harikrishnan , Ji Jiang , James A. Johnson , Muthoni G. Kamau , R. Michael Lawrence , Jianqing Li , John Lloyd , Michael M. Miller , Zulan Pi , Jennifer X. Qiao , Richard A. Rampulla , Jacques Y. Roberge , Tammy C. Wang , Yufeng Wang , Wu Yang
IPC分类号: A61K31/166 , A61K31/137 , A61K31/426 , A61K31/4468 , A61K31/505 , A61K31/695 , A61K31/5375 , A61K31/17 , C07C275/26 , C07C233/73 , C07C37/02 , C07C41/01
CPC分类号: C07C275/26 , C07C211/29 , C07C215/08 , C07C217/58 , C07C229/36 , C07C229/38 , C07C233/09 , C07C233/13 , C07C233/18 , C07C233/56 , C07C233/60 , C07C233/66 , C07C233/73 , C07C233/78 , C07C235/20 , C07C235/34 , C07C235/48 , C07C235/74 , C07C237/06 , C07C237/08 , C07C251/38 , C07C255/13 , C07C255/57 , C07C255/60 , C07C271/16 , C07C271/20 , C07C271/44 , C07C275/24 , C07C311/04 , C07C311/17 , C07C317/44 , C07C323/57 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/08 , C07D207/10 , C07D207/16 , C07D207/26 , C07D207/273 , C07D207/325 , C07D207/38 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/48 , C07D211/38 , C07D211/58 , C07D213/38 , C07D213/40 , C07D213/82 , C07D231/14 , C07D231/40 , C07D239/26 , C07D249/04 , C07D249/06 , C07D249/08 , C07D249/14 , C07D257/04 , C07D257/06 , C07D261/04 , C07D261/08 , C07D261/14 , C07D261/18 , C07D263/34 , C07D271/06 , C07D271/10 , C07D271/113 , C07D277/48 , C07D277/58 , C07D277/60 , C07D285/06 , C07D285/135 , C07D295/155 , C07D303/48 , C07D307/22 , C07D307/24 , C07D307/33 , C07D307/68 , C07D307/79 , C07D307/85 , C07D311/58 , C07D317/46 , C07D319/20 , C07D333/20 , C07D333/24 , C07D333/38 , C07D333/68 , C07D333/70 , C07D471/04 , C07F7/081
摘要: Compounds of formula Ia and Ib wherein A, B, C and R1 are described herein.
摘要翻译: 其中A,B,C和R 1的化合物在此描述。
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公开(公告)号:US20120322761A1
公开(公告)日:2012-12-20
申请号:US13597364
申请日:2012-08-29
申请人: Mark E. Salvati , Heather Finlay , Bang-Chi Chen , Lalgudi S. Harikrishnan , Ji Jiang , James A. Johnson , Muthoni G. Kamau , R. Michael Lawrence , Jianqing Li , John Lloyd , Michael M. Miller , Zulan Pi , Jennifer X. Qiao , Richard A. Rampulla , Jacques Y. Roberge , Tammy C. Wang , Yufeng Wang , Wu Yang
发明人: Mark E. Salvati , Heather Finlay , Bang-Chi Chen , Lalgudi S. Harikrishnan , Ji Jiang , James A. Johnson , Muthoni G. Kamau , R. Michael Lawrence , Jianqing Li , John Lloyd , Michael M. Miller , Zulan Pi , Jennifer X. Qiao , Richard A. Rampulla , Jacques Y. Roberge , Tammy C. Wang , Yufeng Wang , Wu Yang
IPC分类号: C07C275/26 , C07C233/73 , C07C37/02 , C07C41/01 , C07C215/08 , A61K31/166 , A61K31/137 , C07D277/48 , A61K31/426 , C07D211/58 , A61K31/4468 , C07D239/26 , A61K31/505 , C07C41/24 , C07F7/10 , A61K31/695 , C07D295/135 , A61K31/5375 , C07D207/10 , A61K31/40 , A61P25/28 , A61P9/10 , A61P7/02 , A61P9/00 , A61P3/06 , A61P3/00 , A61P9/12 , A61K31/17
CPC分类号: C07C275/26 , C07C211/29 , C07C215/08 , C07C217/58 , C07C229/36 , C07C229/38 , C07C233/09 , C07C233/13 , C07C233/18 , C07C233/56 , C07C233/60 , C07C233/66 , C07C233/73 , C07C233/78 , C07C235/20 , C07C235/34 , C07C235/48 , C07C235/74 , C07C237/06 , C07C237/08 , C07C251/38 , C07C255/13 , C07C255/57 , C07C255/60 , C07C271/16 , C07C271/20 , C07C271/44 , C07C275/24 , C07C311/04 , C07C311/17 , C07C317/44 , C07C323/57 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/08 , C07D207/10 , C07D207/16 , C07D207/26 , C07D207/273 , C07D207/325 , C07D207/38 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/48 , C07D211/38 , C07D211/58 , C07D213/38 , C07D213/40 , C07D213/82 , C07D231/14 , C07D231/40 , C07D239/26 , C07D249/04 , C07D249/06 , C07D249/08 , C07D249/14 , C07D257/04 , C07D257/06 , C07D261/04 , C07D261/08 , C07D261/14 , C07D261/18 , C07D263/34 , C07D271/06 , C07D271/10 , C07D271/113 , C07D277/48 , C07D277/58 , C07D277/60 , C07D285/06 , C07D285/135 , C07D295/155 , C07D303/48 , C07D307/22 , C07D307/24 , C07D307/33 , C07D307/68 , C07D307/79 , C07D307/85 , C07D311/58 , C07D317/46 , C07D319/20 , C07D333/20 , C07D333/24 , C07D333/38 , C07D333/68 , C07D333/70 , C07D471/04 , C07F7/081
摘要: Compounds of formula Ia and Ib wherein A, B, C and R1 are described herein.
摘要翻译: 其中A,B,C和R 1的化合物在此描述。
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公开(公告)号:US08304403B2
公开(公告)日:2012-11-06
申请号:US12797760
申请日:2010-06-10
申请人: Mark E. Salvati , Heather Finlay , Bang-Chi Chen , Lalgudi S. Harikrishnan , Ji Jiang , James A. Johnson , Muthoni G. Kamau , R. Michael Lawrence , Jianqing Li , John Lloyd , Michael M. Miller , Zulan Pi , Jennifer X. Qiao , Richard A. Rampulla , Jacques Y. Roberge , Tammy C. Wang , Yufeng Wang , Wu Yang
发明人: Mark E. Salvati , Heather Finlay , Bang-Chi Chen , Lalgudi S. Harikrishnan , Ji Jiang , James A. Johnson , Muthoni G. Kamau , R. Michael Lawrence , Jianqing Li , John Lloyd , Michael M. Miller , Zulan Pi , Jennifer X. Qiao , Richard A. Rampulla , Jacques Y. Roberge , Tammy C. Wang , Yufeng Wang , Wu Yang
IPC分类号: A61K31/695 , A61K31/17 , A61K31/165 , A61K31/426 , A61K31/4468 , A61K31/50 , A61K31/535 , C07C273/00 , C07D277/20 , C07D211/98 , C07D239/02 , C07D205/08
CPC分类号: C07C275/26 , C07C211/29 , C07C215/08 , C07C217/58 , C07C229/36 , C07C229/38 , C07C233/09 , C07C233/13 , C07C233/18 , C07C233/56 , C07C233/60 , C07C233/66 , C07C233/73 , C07C233/78 , C07C235/20 , C07C235/34 , C07C235/48 , C07C235/74 , C07C237/06 , C07C237/08 , C07C251/38 , C07C255/13 , C07C255/57 , C07C255/60 , C07C271/16 , C07C271/20 , C07C271/44 , C07C275/24 , C07C311/04 , C07C311/17 , C07C317/44 , C07C323/57 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/08 , C07D207/10 , C07D207/16 , C07D207/26 , C07D207/273 , C07D207/325 , C07D207/38 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/48 , C07D211/38 , C07D211/58 , C07D213/38 , C07D213/40 , C07D213/82 , C07D231/14 , C07D231/40 , C07D239/26 , C07D249/04 , C07D249/06 , C07D249/08 , C07D249/14 , C07D257/04 , C07D257/06 , C07D261/04 , C07D261/08 , C07D261/14 , C07D261/18 , C07D263/34 , C07D271/06 , C07D271/10 , C07D271/113 , C07D277/48 , C07D277/58 , C07D277/60 , C07D285/06 , C07D285/135 , C07D295/155 , C07D303/48 , C07D307/22 , C07D307/24 , C07D307/33 , C07D307/68 , C07D307/79 , C07D307/85 , C07D311/58 , C07D317/46 , C07D319/20 , C07D333/20 , C07D333/24 , C07D333/38 , C07D333/68 , C07D333/70 , C07D471/04 , C07F7/081
摘要: Compounds of formula Ia and Ib and wherein A, B, C and R1 are described herein.
摘要翻译: 式Ia和Ib化合物,其中A,B,C和R 1在本文中描述。
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公开(公告)号:US07888376B2
公开(公告)日:2011-02-15
申请号:US11559930
申请日:2006-11-15
申请人: Mark E. Salvati , Heather Finlay , Lalgudi S. Harikrishnan , Ji Jiang , James A. Johnson , Muthoni G. Kamau , R. Michael Lawrence , Michael M. Miller , Jennifer X. Qiao , Tammy C. Wang , Yufeng Wang , Wu Yang
发明人: Mark E. Salvati , Heather Finlay , Lalgudi S. Harikrishnan , Ji Jiang , James A. Johnson , Muthoni G. Kamau , R. Michael Lawrence , Michael M. Miller , Jennifer X. Qiao , Tammy C. Wang , Yufeng Wang , Wu Yang
IPC分类号: C07D213/56 , A61K31/44
CPC分类号: C07D417/06 , C07D213/40 , C07D213/61 , C07D277/28 , C07D401/04 , C07D401/12 , C07D405/06 , C07D405/12 , C07D417/12
摘要: Compounds of formula Ia and Ib wherein A, B, C and R1 are described herein.
摘要翻译: 其中A,B,C和R 1的化合物在此描述。
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7.Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions 有权
标题翻译: P2Y1受体的尿素拮抗剂可用于治疗血栓形成公开(公告)号:US07550499B2
公开(公告)日:2009-06-23
申请号:US11126567
申请日:2005-05-10
IPC分类号: A01N43/38 , A61K31/40 , A61K31/405 , C07D207/00 , C07D209/00 , C07D295/00
CPC分类号: C07D409/04 , C07D209/08 , C07D209/14 , C07D209/96 , C07D215/06 , C07D241/42 , C07D401/04 , C07D401/14 , C07D405/14 , C07D471/10
摘要: The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
摘要翻译: 本发明提供了含有N-芳基或N-杂芳基取代的杂环及其类似物的新型尿素,它们是人P2Y1受体的选择性抑制剂。 本发明还提供了相同的各种药物组合物以及治疗对P2Y1受体活性调节作用的疾病的方法。
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8.Urea antagonists of P2Y1receptor useful in the treatment of thrombotic conditions 有权
标题翻译: P2Y1受体的尿素拮抗剂可用于治疗血栓形成公开(公告)号:US07674828B2
公开(公告)日:2010-03-09
申请号:US12117005
申请日:2008-05-08
申请人: Hannguang J. Chao , Huji Tuerdi , Timothy F. Herpin , Jacques Y. Roberge , Yalei Liu , Michael R. Lawrence , Robert P. Rehfuss , Charles G. Clark , Jennifer X. Qiao , Timur Gungor , Patrick Y. S. Lam , Tammy C. Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora M. Schnur
发明人: Hannguang J. Chao , Huji Tuerdi , Timothy F. Herpin , Jacques Y. Roberge , Yalei Liu , Michael R. Lawrence , Robert P. Rehfuss , Charles G. Clark , Jennifer X. Qiao , Timur Gungor , Patrick Y. S. Lam , Tammy C. Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora M. Schnur
IPC分类号: A61K31/155 , C07C275/28
CPC分类号: C07D409/14 , C07C275/30 , C07C275/32 , C07D213/40 , C07D213/75 , C07D213/89 , C07D231/40 , C07D231/50 , C07D237/22 , C07D333/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07F7/1804
摘要: The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
摘要翻译: 本发明提供了作为人P2Y1受体的选择性抑制剂的新颖的吡啶基或苯基脲及其类似物。 本发明还提供了相同的各种药物组合物以及治疗对P2Y1受体活性调节作用的疾病的方法。
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9.Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors 有权
标题翻译: 含内含物的环状二胺及其衍生物作为Xa因子抑制剂公开(公告)号:US07205318B2
公开(公告)日:2007-04-17
申请号:US10801469
申请日:2004-03-16
申请人: Jennifer X. Qiao , Tammy C. Wang , Gren Z. Wang , Timur Gungor
发明人: Jennifer X. Qiao , Tammy C. Wang , Gren Z. Wang , Timur Gungor
IPC分类号: A61K31/445 , C07D453/02
CPC分类号: C07D213/64 , C07D213/75 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要: The present application describes lactam-containing cyclic diamines and derivatives thereof of Formula I: P4-M-M4I or pharmaceutically acceptable salt forms thereof, wherein M is a non-aromatic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
摘要翻译: 本申请描述了含有内酰胺的环状二胺及其衍生物
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10.N-linked heterocyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions 有权
标题翻译: 可用于治疗血栓形成条件的P2Y1受体的N-连接杂环拮抗剂公开(公告)号:US08329718B2
公开(公告)日:2012-12-11
申请号:US12761447
申请日:2010-04-16
申请人: Jennifer X. Qiao , Tammy C. Wang , James C. Sutton , Timur Gungor
发明人: Jennifer X. Qiao , Tammy C. Wang , James C. Sutton , Timur Gungor
IPC分类号: A61K31/44 , A61K31/425 , C07D209/54 , C07D409/10 , C07D401/02 , C07D233/54
CPC分类号: C07D471/10 , C07D401/04 , C07D401/12 , C07D417/12 , C07D417/14
摘要: The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, D and W are as defined herein. These compounds are selective inhibitors of the human P2Y1 receptor which can be used as medicaments.
摘要翻译: 本发明提供了包含式(I)的N-芳基或N-杂芳基取代的杂环的新型脲:或其立体异构体,互变异构体,药学上可接受的盐或溶剂化物形式,其中变量A,B,D和W如本文所定义 。 这些化合物是可用作药物的人P2Y1受体的选择性抑制剂。
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