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公开(公告)号:US06077858A
公开(公告)日:2000-06-20
申请号:US401416
申请日:1999-09-21
申请人: Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
发明人: Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
IPC分类号: C07D409/14 , C07D487/08 , A61K31/44
CPC分类号: C07D409/14 , C07D487/08
摘要: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号:US5985901A
公开(公告)日:1999-11-16
申请号:US83479
申请日:1998-05-22
申请人: Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
发明人: Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
IPC分类号: C07D401/12 , C07D403/12 , C07D413/12 , C07D521/00 , A61K31/44
CPC分类号: C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D413/12
摘要: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号:US5981550A
公开(公告)日:1999-11-09
申请号:US83574
申请日:1998-05-22
申请人: Mark Goulet , Thomas F. Walsh , Feroze Ujjainwalla , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
发明人: Mark Goulet , Thomas F. Walsh , Feroze Ujjainwalla , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
IPC分类号: C07D409/14 , C07D487/08 , C07D401/12 , A61K31/44
CPC分类号: C07D409/14 , C07D487/08
摘要: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号:US6156772A
公开(公告)日:2000-12-05
申请号:US312192
申请日:1999-05-14
IPC分类号: A61K45/06 , C07D401/12 , C07D401/14 , C07D491/08 , A01N43/40 , A01N43/38 , C07D209/02 , C07D401/00 , C07D405/00
CPC分类号: C07D401/12 , A61K45/06 , C07D401/14 , C07D491/08
摘要: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号:US6004984A
公开(公告)日:1999-12-21
申请号:US83491
申请日:1998-05-22
IPC分类号: C07D409/14 , C07D487/08 , C07D401/12 , A61K31/44
CPC分类号: C07D409/14 , C07D487/08
摘要: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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6.
公开(公告)号:US07015235B2
公开(公告)日:2006-03-21
申请号:US10468515
申请日:2002-02-25
申请人: Mark T. Goulet , Ravi P. Nargund , Iyassu K. Sebhat , Feroze Ujjainwalla , Thomas F. Walsh , Daniel Warner , Zhixiong Ye , Jonathan R. Young , Raman K. Bakshi
发明人: Mark T. Goulet , Ravi P. Nargund , Iyassu K. Sebhat , Feroze Ujjainwalla , Thomas F. Walsh , Daniel Warner , Zhixiong Ye , Jonathan R. Young , Raman K. Bakshi
IPC分类号: A61K31/445 , C07D211/06
CPC分类号: C07D491/08 , A61K31/445 , C07D211/62 , C07D211/64 , C07D401/06 , C07D401/14 , C07D413/06 , C07D413/14
摘要: Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
摘要翻译: 某些新的4-取代N-酰化哌啶衍生物是人黑皮质素受体的激动剂,特别是人黑皮质素-4受体(MC-4R)的选择性激动剂。 因此,它们可用于治疗,控制或预防对MC-4R的活化反应的疾病和病症,例如肥胖,糖尿病,性功能障碍,包括勃起功能障碍和女性性功能障碍。
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公开(公告)号:US6110931A
公开(公告)日:2000-08-29
申请号:US276028
申请日:1999-03-25
IPC分类号: A61P5/02 , C07D519/00 , A61K31/437 , A61K31/4375 , C07D471/04 , C07D487/04
CPC分类号: C07D519/00
摘要: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号:US6025366A
公开(公告)日:2000-02-15
申请号:US275754
申请日:1999-03-25
IPC分类号: C07D471/04 , C07D519/00 , A61K31/435
CPC分类号: C07D471/04
摘要: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号:US06211224B1
公开(公告)日:2001-04-03
申请号:US09178688
申请日:1998-10-26
IPC分类号: A61K31404
CPC分类号: C07D209/14
摘要: There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
摘要翻译: 公开了式(I)化合物及其药学上可接受的盐,其可用作GnRH的拮抗剂,因此可用于治疗男性和女性中各种性激素相关和其他病症。
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公开(公告)号:US6159989A
公开(公告)日:2000-12-12
申请号:US465199
申请日:1999-12-15
IPC分类号: A61P15/08 , C07D453/06 , C07D487/08 , A61K31/405 , A61K31/454 , C07D211/26 , C07D401/14
CPC分类号: C07D487/08 , C07D453/06
摘要: There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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