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公开(公告)号:US20060035935A1
公开(公告)日:2006-02-16
申请号:US11239721
申请日:2005-09-30
申请人: Mark Goulet , Ravi Nargund , Iyassu Sebhat , Feroze Ujjainwalla , Thomas Walsh , Daniel Warner , Zhixiong Ye , Jonathan Young , Raman Bakshi
发明人: Mark Goulet , Ravi Nargund , Iyassu Sebhat , Feroze Ujjainwalla , Thomas Walsh , Daniel Warner , Zhixiong Ye , Jonathan Young , Raman Bakshi
IPC分类号: A61K31/454 , C07D417/02 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号: C07D491/08 , A61K31/445 , C07D211/62 , C07D211/64 , C07D401/06 , C07D401/14 , C07D413/06 , C07D413/14
摘要: Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
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公开(公告)号:US20060025442A1
公开(公告)日:2006-02-02
申请号:US11239770
申请日:2005-09-30
申请人: Mark Goulet , Ravi Nargund , Feroze Ujjainwalla , Thomas Walsh , Daniel Warner
发明人: Mark Goulet , Ravi Nargund , Feroze Ujjainwalla , Thomas Walsh , Daniel Warner
IPC分类号: A61K31/4545 , A61K31/454 , C07D401/02
CPC分类号: C07D413/06 , C07D211/26 , C07D211/28 , C07D211/62 , C07D413/14
摘要: Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
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3.
公开(公告)号:US07015235B2
公开(公告)日:2006-03-21
申请号:US10468515
申请日:2002-02-25
申请人: Mark T. Goulet , Ravi P. Nargund , Iyassu K. Sebhat , Feroze Ujjainwalla , Thomas F. Walsh , Daniel Warner , Zhixiong Ye , Jonathan R. Young , Raman K. Bakshi
发明人: Mark T. Goulet , Ravi P. Nargund , Iyassu K. Sebhat , Feroze Ujjainwalla , Thomas F. Walsh , Daniel Warner , Zhixiong Ye , Jonathan R. Young , Raman K. Bakshi
IPC分类号: A61K31/445 , C07D211/06
CPC分类号: C07D491/08 , A61K31/445 , C07D211/62 , C07D211/64 , C07D401/06 , C07D401/14 , C07D413/06 , C07D413/14
摘要: Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
摘要翻译: 某些新的4-取代N-酰化哌啶衍生物是人黑皮质素受体的激动剂,特别是人黑皮质素-4受体(MC-4R)的选择性激动剂。 因此,它们可用于治疗,控制或预防对MC-4R的活化反应的疾病和病症,例如肥胖,糖尿病,性功能障碍,包括勃起功能障碍和女性性功能障碍。
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4.
公开(公告)号:US06818658B2
公开(公告)日:2004-11-16
申请号:US10356879
申请日:2003-02-03
申请人: Feroze Ujjainwalla , Lin Chu , Mark T. Goulet , Bonnie Louridas , Matthew J. Wyvratt , Daniel Warner
发明人: Feroze Ujjainwalla , Lin Chu , Mark T. Goulet , Bonnie Louridas , Matthew J. Wyvratt , Daniel Warner
IPC分类号: A61K31445
CPC分类号: C07D491/08 , A61K31/445 , C07D211/62 , C07D211/64 , C07D401/06 , C07D401/14 , C07D413/06 , C07D413/14
摘要: Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
摘要翻译: 某些新的4-取代的N-酰化哌啶衍生物是人类黑皮质素受体的激动剂,特别是人黑皮质素-4受体(MC-4R)的选择性激动剂。 因此,它们可用于治疗,控制或预防对MC-4R的激活反应的疾病和病症,例如肥胖,糖尿病,性功能障碍,包括勃起功能障碍和女性性功能障碍。
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公开(公告)号:US07012084B2
公开(公告)日:2006-03-14
申请号:US10468517
申请日:2002-02-25
IPC分类号: A61K31/445 , C07D211/06
CPC分类号: C07D413/06 , C07D211/26 , C07D211/28 , C07D211/62 , C07D413/14
摘要: Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
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6.
公开(公告)号:US07700778B2
公开(公告)日:2010-04-20
申请号:US11239770
申请日:2005-09-30
IPC分类号: C07D401/06 , A61K31/454 , A61K31/451
CPC分类号: C07D413/06 , C07D211/26 , C07D211/28 , C07D211/62 , C07D413/14
摘要: Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
摘要翻译: 某些新的4-取代的N-酰化哌啶衍生物是人类黑皮质素受体的激动剂,特别是人黑皮质素-4受体(MC-4R)的选择性激动剂。 因此,它们可用于治疗,控制或预防对MC-4R的激活反应的疾病和病症,例如肥胖,糖尿病,性功能障碍,包括勃起功能障碍和女性性功能障碍。
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