公开(公告)号：US20120123303A1

公开(公告)日：2012-05-17

申请号：US13243134

申请日：2011-09-23

申请人： David Sogard ,  Scott Smith ,  Mark L. Jenson

发明人： David Sogard ,  Scott Smith ,  Mark L. Jenson

IPC分类号： A61B18/18 ,  A61B18/04 ,  A61N7/00 ,  A61B18/00

CPC分类号： A61B18/1492 ,  A61B90/37 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/0212 ,  A61N5/062 ,  A61N7/022 ,  A61N2005/067 ,  A61N2007/003

摘要： An elongated flexible medical device is inserted into a patient's body via a natural orifice, and advanced through the natural orifice to a location proximate innervated tissue that influences renal sympathetic nerve activity. The medical device can be advanced into a body organ and to a location within the organ proximate the innervated tissue. The organ may comprise an organ of the gastrointestinal tract or urinary tract. The medical device may be advanced through and beyond an access hole in a wall of the organ, and situated at a location proximate the innervated tissue. One or both of imaging and ablation energy is delivered from a distal end of the medical device to the innervated tissue. Innervated renal tissue can be ablated using various forms of energy, including RF energy, ultrasound energy, optical energy, and thermal energy.

摘要翻译： 细长的柔性医疗装置通过自然孔插入患者体内，并通过自然孔推进到影响肾交感神经活动的靠近神经组织的位置。 医疗装置可以进入身体器官和靠近神经组织的器官内的位置。 器官可以包括胃肠道或泌尿道的器官。 医疗装置可以前进穿过器官壁中的进入孔并且位于邻近神经组织的位置处。 成像和消融能量中的一个或两个从医疗装置的远端传送到神经组织。 可以使用各种形式的能量消融内源性肾组织，包括射频能量，超声能量，光能和热能。

公开(公告)号：US20120172870A1

公开(公告)日：2012-07-05

申请号：US13303130

申请日：2011-11-22

申请人： Mark L. Jenson ,  Scott Smith ,  David Sogard

发明人： Mark L. Jenson ,  Scott Smith ,  David Sogard

IPC分类号： A61B18/18

CPC分类号： A61B18/1492 ,  A61B2018/00029 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/1465 ,  A61B2090/065

摘要： An electrode is provided at a distal end of a catheter and dimensioned for deployment within a renal artery. A deformable cover of the electrode incorporates a force-activatable conduction apparatus. The cover is configured to conduct electrical energy only through a region or regions of the cover subject to deformation due to contact with a wall of the target vessel. The electrical energy is sufficient to ablate perivascular renal nerves proximate the deformed region or regions of the electrode cover. The cover is configured to prevent conduction of electrical energy through the cover in the absence of a deformation force applied to the cover.

摘要翻译： 在导管的远端设置电极，其尺寸适于在肾动脉内展开。 电极的可变形的外壳包含一个力可激活的传导装置。 盖被配置成仅通过与目标容器的壁接触而受到变形的区域或区域传导电能。 电能足以消除靠近变形区域或电极盖的区域的血管周围肾神经。 盖被配置成在没有施加到盖的变形力的情况下防止电能通过盖的传导。

公开(公告)号：US09023034B2

公开(公告)日：2015-05-05

申请号：US13303130

申请日：2011-11-22

申请人： Mark L. Jenson ,  Scott Smith ,  David Sogard

发明人： Mark L. Jenson ,  Scott Smith ,  David Sogard

IPC分类号： A61B18/24 ,  A61B18/14 ,  A61B18/00 ,  A61B19/00

CPC分类号： A61B18/1492 ,  A61B2018/00029 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/1465 ,  A61B2090/065

摘要： An electrode is provided at a distal end of a catheter and dimensioned for deployment within a renal artery. A deformable cover of the electrode incorporates a force-activatable conduction apparatus. The cover is configured to conduct electrical energy only through a region or regions of the cover subject to deformation due to contact with a wall of the target vessel. The electrical energy is sufficient to ablate perivascular renal nerves proximate the deformed region or regions of the electrode cover. The cover is configured to prevent conduction of electrical energy through the cover in the absence of a deformation force applied to the cover.

摘要翻译： 在导管的远端设置电极，其尺寸适于在肾动脉内展开。 电极的可变形的外壳包含一个力可激活的传导装置。 盖被配置成仅通过与目标容器的壁接触而受到变形的区域或区域传导电能。 电能足以消除靠近变形区域或电极盖的区域的血管周围肾神经。 盖被配置成在没有施加到盖的变形力的情况下防止电能通过盖的传导。

公开(公告)号：US20120265198A1

公开(公告)日：2012-10-18

申请号：US13299932

申请日：2011-11-18

申请人： Loren M. Crow ,  Mark L. Jenson ,  Scott Smith

发明人： Loren M. Crow ,  Mark L. Jenson ,  Scott Smith

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B2018/0016 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/124 ,  A61N1/36007 ,  A61N7/022

摘要： Stimulation energy is delivered to one or more renal artery sites in accordance with a predetermined energy delivery protocol. The stimulation energy is sufficient to elicit a physiologic response from the patient but insufficient to ablate renal nerves. Target renal artery sites that elicit a physiologic response are identified, and renal nerve tissue at or proximate the target sites is ablated.

摘要翻译： 根据预定的能量递送方案，将刺激能量递送至一个或多个肾动脉部位。 刺激能量足以引起患者的生理反应，但不足以消融肾神经。 确定引起生理反应的目标肾动脉部位，消除靶点位置或其附近的肾神经组织。

公开(公告)号：US20120029513A1

公开(公告)日：2012-02-02

申请号：US13194920

申请日：2011-07-30

申请人： Scott Smith ,  Leonard B. Richardson ,  Mark L. Jenson

发明人： Scott Smith ,  Leonard B. Richardson ,  Mark L. Jenson

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B18/1815 ,  A61B18/20 ,  A61B90/39 ,  A61B2018/00011 ,  A61B2018/00434 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61M25/0054 ,  A61M25/0113 ,  A61M25/0127 ,  A61M25/0138 ,  A61M25/0147

摘要： A catheter is configured to access a renal artery. A lumen of the catheter's shaft is dimensioned to receive a flexible actuation member which extends between the shaft's proximal and distal ends. The actuation member is moveable within the lumen and subject to elastic deformation, friction, and/or whip along its length. A flexible support member is coupled to a distal end of the actuation member and extendible beyond a distal tip of the shaft. An RF ablation electrode at a distal end of the support member is configured to ablated perivascular renal nerve tissue. A position converter at the distal end of the shaft is configured to convert movement of the actuation member into one or both of controlled rotational and axial movement of the support member and electrode to one of a multiplicity of stable circumferential positions substantially free of elastic deformation, friction, and/or whip impacting actuation member movement.

摘要翻译： 导管配置成进入肾动脉。 导管轴的内腔的尺寸被设计成容纳在轴的近端和远端之间延伸的柔性致动构件。 致动构件可在内腔内移动并且沿其长度受到弹性变形，摩擦和/或鞭状。 柔性支撑构件联接到致动构件的远端并且可延伸超过轴的远侧末端。 在支撑构件的远端处的RF消融电极被配置为消融血管周围肾神经组织。 在轴的远端处的位置转换器被配置为将致动构件的运动转换成支撑构件和电极的受控旋转和轴向运动到基本上没有弹性变形的多个稳定的圆周位置中的一个或两个， 摩擦和/或搅动撞击致动构件运动。

公开(公告)号：US09668811B2

公开(公告)日：2017-06-06

申请号：US13243134

申请日：2011-09-23

申请人： David J. Sogard ,  Scott Smith ,  Mark L. Jenson

发明人： David J. Sogard ,  Scott Smith ,  Mark L. Jenson

IPC分类号： A61H1/00 ,  A61B18/14 ,  A61N5/06 ,  A61B18/00 ,  A61B18/02 ,  A61N7/02 ,  A61N7/00 ,  A61N5/067 ,  A61B90/00

CPC分类号： A61B18/1492 ,  A61B90/37 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/0212 ,  A61N5/062 ,  A61N7/022 ,  A61N2005/067 ,  A61N2007/003

摘要： An elongated flexible medical device is inserted into a patient's body via a natural orifice, and advanced through the natural orifice to a location proximate innervated tissue that influences renal sympathetic nerve activity. The medical device can be advanced into a body organ and to a location within the organ proximate the innervated tissue. The organ may comprise an organ of the gastrointestinal tract or urinary tract. The medical device may be advanced through and beyond an access hole in a wall of the organ, and situated at a location proximate the innervated tissue. One or both of imaging and ablation energy is delivered from a distal end of the medical device to the innervated tissue. Innervated renal tissue can be ablated using various forms of energy, including RF energy, ultrasound energy, optical energy, and thermal energy.

公开(公告)号：US20120157992A1

公开(公告)日：2012-06-21

申请号：US13243724

申请日：2011-09-23

申请人： Scott Smith ,  Mark L. Jenson

发明人： Scott Smith ,  Mark L. Jenson

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B90/39 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00821 ,  A61B2018/00875

摘要： An ablation apparatus includes a catheter, a conductor arrangement provided along the catheter, and one or more electrodes provided at a distal end of the catheter. A flexible structure maintains the one or more electrode elements in a spaced relationship relative to an inner wall of the renal artery when in a deployed configuration. Each electrode is coupled to the conductor arrangement and configured to deliver energy sufficient to ablate perivascular renal nerve tissue. The flexible structure may comprise a basket structure and at least one electrode is situated within the basket structure. The flexible structure may comprise a tube structure having spaced-apart electrically non-conductive segments, and at least one electrode is situated between adjacent electrically non-conductive segments.

摘要翻译： 消融装置包括导管，沿导管设置的导体装置和设置在导管远端的一个或多个电极。 当处于展开构型时，柔性结构将一个或多个电极元件相对于肾动脉的内壁保持间隔开的关系。 每个电极耦合到导体装置并且被配置成输送足以消除血管周围肾神经组织的能量。 柔性结构可以包括篮状结构，并且至少一个电极位于篮状结构内。 柔性结构可以包括具有间隔开的非导电段的管结构，并且至少一个电极位于相邻的非导电段之间。

公开(公告)号：US09358365B2

公开(公告)日：2016-06-07

申请号：US13194920

申请日：2011-07-30

申请人： Scott Smith ,  Leonard B. Richardson ,  Mark L. Jenson

发明人： Scott Smith ,  Leonard B. Richardson ,  Mark L. Jenson

IPC分类号： A61B18/14 ,  A61M25/01 ,  A61B18/18 ,  A61B18/20 ,  A61B19/00 ,  A61B18/00 ,  A61M25/00

CPC分类号： A61B18/1492 ,  A61B18/1815 ,  A61B18/20 ,  A61B90/39 ,  A61B2018/00011 ,  A61B2018/00434 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61M25/0054 ,  A61M25/0113 ,  A61M25/0127 ,  A61M25/0138 ,  A61M25/0147

摘要： A catheter is configured to access a renal artery. A lumen of the catheter's shaft is dimensioned to receive a flexible actuation member which extends between the shaft's proximal and distal ends. The actuation member is moveable within the lumen and subject to elastic deformation, friction, and/or whip along its length. A flexible support member is coupled to a distal end of the actuation member and extendible beyond a distal tip of the shaft. An RF ablation electrode at a distal end of the support member is configured to ablated perivascular renal nerve tissue. A position converter at the distal end of the shaft is configured to convert movement of the actuation member into one or both of controlled rotational and axial movement of the support member and electrode to one of a multiplicity of stable circumferential positions substantially free of elastic deformation, friction, and/or whip impacting actuation member movement.

摘要翻译： 导管配置成进入肾动脉。 导管轴的内腔的尺寸被设计成容纳在轴的近端和远端之间延伸的柔性致动构件。 致动构件可在内腔内移动并且沿其长度受到弹性变形，摩擦和/或鞭状。 柔性支撑构件联接到致动构件的远端并且可延伸超过轴的远侧末端。 在支撑构件的远端处的RF消融电极被配置为消融血管周围肾神经组织。 在轴的远端处的位置转换器被配置为将致动构件的运动转换成支撑构件和电极的受控旋转和轴向运动到基本上没有弹性变形的多个稳定的圆周位置中的一个或两个， 摩擦和/或搅动撞击致动构件运动。

公开(公告)号：US20120157993A1

公开(公告)日：2012-06-21

申请号：US13243736

申请日：2011-09-23

申请人： Mark L. Jenson ,  Scott Smith

发明人： Mark L. Jenson ,  Scott Smith

IPC分类号： A61B18/16

CPC分类号： A61B18/1492 ,  A61B2018/00267 ,  A61B2018/00434 ,  A61B2018/00577 ,  A61B2018/00821 ,  A61B2018/00875

摘要： A first spacing structure is provided at a distal end of a first catheter. The first spacing structure is configured to position at least one arterial electrode at a predefined distance away from a wall of the renal artery. A second spacing structure is provided at the distal end of the first catheter or at a distal end of a second catheter. The second spacing structure is configured to position at least one aortal electrode at a predefined distance away from a wall of the aorta. The arterial and aortal electrodes are operable as a bipolar electrode arrangement. The first and second spacing structures respectively maintain the arterial and aortal electrodes at a predefined distance away from the renal artery and aortal walls while electrical energy sufficient to ablate perivascular nerve tissue adjacent the renal artery and aortal walls is delivered by the bipolar electrode arrangement.

摘要翻译： 第一间隔结构设置在第一导管的远端。 第一间隔结构构造成将远离肾动脉壁的预定距离定位至少一个动脉电极。 第二间隔结构设置在第一导管的远端处或在第二导管的远端处。 第二间隔结构被配置为将至少一个主动脉电极定位成远离主动脉壁的预定距离。 动脉和主动脉电极可操作为双极电极装置。 第一和第二间隔结构分别将动脉和主动脉电极保持在远离肾动脉和主动脉壁的预定距离处，同时通过双极电极装置输送足以消除邻近肾动脉和主动脉壁的血管周围神经组织的电能。

公开(公告)号：US09463062B2

公开(公告)日：2016-10-11

申请号：US13188677

申请日：2011-07-22

申请人： Scott Smith ,  Joe Koblish ,  Mark L. Jenson ,  Roger Hastings

发明人： Scott Smith ,  Joe Koblish ,  Mark L. Jenson ,  Roger Hastings

IPC分类号： A61B18/18 ,  A61B18/14 ,  A61B18/00

CPC分类号： A61B18/1492 ,  A61B2018/00029 ,  A61B2018/00035 ,  A61B2018/00065 ,  A61B2018/0016 ,  A61B2018/0022 ,  A61B2018/00238 ,  A61B2018/00285 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00821 ,  A61B2018/1472

摘要： A catheter includes a flexible shaft having a lumen arrangement and a length sufficient to access a target vessel of a patient. A balloon at the distal end of the shaft is fluidly coupled to the lumen arrangement. The balloon body comprises a first material and a second material different from the first material. The second material comprises a hydrophilic polymer that becomes electrically conductive in response to absorption of the conductive fluid. The fluid conductive regions facilitate perfusion of the conductive fluid through the balloon body to an inner wall of the target vessel during ablation of perivascular tissues. A cooling arrangement is configured for one of receiving a thermal transfer fluid from the lumen arrangement or facilitating perfusion of blood passing through the target vessel to cool the balloon body during ablation of the perivascular tissues.

摘要翻译： 导管包括柔性轴，其具有管腔布置和足以进入患者的目标血管的长度。 在轴的远端处的气囊流体地联接到管腔装置。 球囊体包括第一材料和与第一材料不同的第二材料。 第二种材料包括响应于导电流体的吸收变得导电的亲水性聚合物。 流体导电区域便于在血管周围组织消融期间将导电流体通过球囊体灌注到目标血管的内壁。 冷却装置构造成用于接收来自管腔装置的热转移流体，或者促进血液通过靶血管的灌注，以在血管周围组织消融期间冷却球囊体。