公开(公告)号：US20120165794A1

公开(公告)日：2012-06-28

申请号：US12976761

申请日：2010-12-22

申请人： Mark S. Ortiz ,  Christopher J. Hess ,  Jason L. Harris ,  James W. Voegele ,  Mark S. Zeiner ,  Mark D. Overmyer ,  Joseph B. Kraimer ,  Jeff Shimizu ,  Rocco Crivelli ,  Yanik Tardy ,  Thierry Utard ,  Juergen Burger ,  Toralf Bork ,  Martin Pfleiderer ,  Olivier Chossat

发明人： Mark S. Ortiz ,  Christopher J. Hess ,  Jason L. Harris ,  James W. Voegele ,  Mark S. Zeiner ,  Mark D. Overmyer ,  Joseph B. Kraimer ,  Jeff Shimizu ,  Rocco Crivelli ,  Yanik Tardy ,  Thierry Utard ,  Juergen Burger ,  Toralf Bork ,  Martin Pfleiderer ,  Olivier Chossat

IPC分类号： A61M31/00

CPC分类号： A61B1/041 ,  A61B1/00147 ,  A61F5/0013 ,  A61M31/002

摘要： Devices and related methods are provided for the controlled delivery of a therapeutic to a targeted location within a body. More particularly, methods and devices are provided for controlling the rate of passage of an orally administered pill through a body, as well as for controlling the delivery of a therapeutic within the pill at a specific location within the body. Various types of devices, generally referred to herein as “catchers,” are provided that can actively catch a pill as it passes through a body. The catcher can hold the pill at a specific location within the body until a predetermined event occurs, such as partial or complete administration of a therapeutic within the pill. The catcher can then release the pill upon command and/or upon the occurrence of the predetermined event to allow the pill to pass out of the body. In other embodiments, various types of pills are provided that can actively engage a catcher and remain engaged with the catcher until a predetermined event occurs.

公开(公告)号：US20150045850A1

公开(公告)日：2015-02-12

申请号：US13825459

申请日：2012-03-30

申请人： Toralf Bork ,  Rocco Crivelli ,  Mathilde Miguras ,  Martin Pfleiderer ,  Yanik Tardy ,  Jason L. Harris ,  Mark S. Ortiz ,  Alessandro Pastorelli ,  Michele D' Arcangelo

发明人： Toralf Bork ,  Rocco Crivelli ,  Mathilde Miguras ,  Martin Pfleiderer ,  Yanik Tardy ,  Jason L. Harris ,  Mark S. Ortiz ,  Alessandro Pastorelli ,  Michele D' Arcangelo

IPC分类号： A61N1/36 ,  A61F5/00

CPC分类号： A61N1/36007 ,  A61F5/0026 ,  A61F2005/0016 ,  A61F2005/002 ,  A61N1/0509 ,  A61N1/0517

摘要： An implantable system for stimulating the release of satiety hormone in a subject comprises a stimulus device (11) which is implantable in the subject and adapted to apply an electrical stimulus to a tissue of a gastrointestinal system of said subject, and a detection device which is implantable in the subject and adapted to continuously monitoring at least one of a mechanical characteristic and an electrical characteristic of the subject to detect an ingestion of food by said subject, wherein the detection device cooperates with the stimulus device (11) such that the stimulus device (11) applies said electrical stimulus in response to a detected ingestion of food.

摘要翻译： 用于刺激受试者中的饱腹感激素的释放的可植入系统包括刺激装置（11），其可植入对象中并适于对所述受试者的胃肠系统的组织施加电刺激，以及检测装置 可植入在受试者中并且适于连续地监测受试者的机械特性和电特性中的至少一个以检测所述受试者摄入的食物，其中检测装置与刺激装置（11）配合使得刺激装置 （11）响应于检测到的食物摄入而应用所述电刺激。

公开(公告)号：US09427580B2

公开(公告)日：2016-08-30

申请号：US13825459

申请日：2012-03-30

申请人： Toralf Bork ,  Rocco Crivelli ,  Mathilde Miguras ,  Martin Pfleiderer ,  Yanik Tardy ,  Jason L. Harris ,  Mark S. Ortiz ,  Alessandro Pastorelli ,  Michele D'Arcangelo

发明人： Toralf Bork ,  Rocco Crivelli ,  Mathilde Miguras ,  Martin Pfleiderer ,  Yanik Tardy ,  Jason L. Harris ,  Mark S. Ortiz ,  Alessandro Pastorelli ,  Michele D'Arcangelo

IPC分类号： A61N1/36 ,  A61N1/05 ,  A61F5/00

CPC分类号： A61N1/36007 ,  A61F5/0026 ,  A61F2005/0016 ,  A61F2005/002 ,  A61N1/0509 ,  A61N1/0517

摘要： An implantable system for stimulating the release of satiety hormone in a subject comprises a stimulus device which is implantable in the subject and adapted to apply an electrical stimulus to a tissue of a gastrointestinal system of said subject, and a detection device which is implantable in the subject and adapted to continuously monitoring at least one of a mechanical characteristic and an electrical characteristic of the subject to detect an ingestion of food by said subject, wherein the detection device cooperates with the stimulus device such that the stimulus device applies said electrical stimulus in response to a detected ingestion of food.

摘要翻译： 用于刺激受试者中的饱腹感激素的释放的可植入系统包括刺激装置，该刺激装置可植入受试者并适于对所述受试者的胃肠系统的组织施加电刺激，以及可植入在所述受试者中的检测装置 受试者并且适于连续监测受试者的机械特征和电特性中的至少一个以检测所述受试者摄取食物，其中所述检测装置与刺激装置配合使得刺激装置应答所述电刺激 检测到摄入食物。

公开(公告)号：US20110295178A1

公开(公告)日：2011-12-01

申请号：US13104321

申请日：2011-05-10

申请人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Gregory J. Bakos ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, JR. ,  Jason L. Harris ,  Christopher J. Hess ,  John V. Hunt ,  Prasanna Malaviya ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  Suzanne Thompson ,  Richard W. Timm ,  James W. Voegele ,  William B. Weisenburgh, II ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, JR. ,  David C. Yates ,  Mark S. Zeiner ,  Andrew M. Zwolinski

发明人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Gregory J. Bakos ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, JR. ,  Jason L. Harris ,  Christopher J. Hess ,  John V. Hunt ,  Prasanna Malaviya ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  Suzanne Thompson ,  Richard W. Timm ,  James W. Voegele ,  William B. Weisenburgh, II ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, JR. ,  David C. Yates ,  Mark S. Zeiner ,  Andrew M. Zwolinski

IPC分类号： A61M5/00

CPC分类号： A61F5/0079 ,  A61K9/0065 ,  A61M5/14276 ,  A61M31/002 ,  A61M39/0208 ,  A61M2210/106 ,  A61M2210/1064

摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices may be accomplished via stabilized implantable systems and ingestible pills. In one aspect, a method of inducing satiety includes implanting an implant within a lumen of a gastrointestinal tract and retaining a portion of chyme that flows by the implant within a body of the implant. The method further involves re-releasing the retained chyme from the implant into the gastrointestinal tract at a predetermined rate slower than a rate caused by natural peristalsis.

摘要翻译： 方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。 这些方法和装置可以通过稳定的可植入系统和可摄取的药丸来实现。 一方面，一种诱导饱腹感的方法包括将植入物植入胃肠道的内腔中，并且将植入物流动的部分保持在植入物的体内。 该方法还包括以比由天然蠕动引起的速率慢的预定速率将留置的食糜从植入物再释放到胃肠道中。

公开(公告)号：US20110295180A1

公开(公告)日：2011-12-01

申请号：US13105029

申请日：2011-05-11

申请人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, JR. ,  Jason L. Harris ,  Christopher J. Hess ,  Thomas W. Huitema ,  John V. Hunt ,  Prasanna Malaviya ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  Foster B. Stulen ,  James W. Voegele ,  William B. Weisenburgh, II ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, JR. ,  David C. Yates ,  Mark S. Zeiner ,  Andrew M. Zwolinski

发明人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, JR. ,  Jason L. Harris ,  Christopher J. Hess ,  Thomas W. Huitema ,  John V. Hunt ,  Prasanna Malaviya ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  Foster B. Stulen ,  James W. Voegele ,  William B. Weisenburgh, II ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, JR. ,  David C. Yates ,  Mark S. Zeiner ,  Andrew M. Zwolinski

IPC分类号： A61F2/04

CPC分类号： A61F5/0076 ,  A61F2/04 ,  A61F5/0013 ,  A61F5/0026 ,  A61F5/0079 ,  A61F2002/045

摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems, and ingestible pills. In one embodiment, the implantable system comprises a device delivering a therapeutic substance to a target location within the gastrointestinal tract of a patient in order to initiate an intestinal braking effect which would promote sensations of satiety and stimulate excess weight loss for the patient.

摘要翻译： 方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。 这些方法和装置通过稳定的可植入系统和可摄取的药丸来实现。 在一个实施方案中，可植入系统包括将治疗物质递送到患者胃肠道内的目标位置的装置，以便开始肠促动作用，其将促进饱腹感，并刺激患者多余的体重减轻。

公开(公告)号：US08876761B2

公开(公告)日：2014-11-04

申请号：US13104313

申请日：2011-05-10

申请人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, Jr. ,  Jason L. Harris ,  Christopher J. Hess ,  Prasanna Malaviya ,  Glenda C. Marsh ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  James W. Voegele ,  Lauren S. Weaner ,  William B. Weisenburgh, II ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, Jr. ,  David C. Yates ,  Mark S. Zeiner ,  Andrew M. Zwolinski

发明人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, Jr. ,  Jason L. Harris ,  Christopher J. Hess ,  Prasanna Malaviya ,  Glenda C. Marsh ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  James W. Voegele ,  Lauren S. Weaner ,  William B. Weisenburgh, II ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, Jr. ,  David C. Yates ,  Mark S. Zeiner ,  Andrew M. Zwolinski

IPC分类号： A61M31/00 ,  A61K9/00 ,  A61M5/142 ,  A61F5/00 ,  A61N1/05 ,  A61M39/02 ,  A61F2/04 ,  A61N1/36 ,  A61N1/372

CPC分类号： A61M31/002 ,  A61F2/04 ,  A61F5/0013 ,  A61F5/0026 ,  A61F2002/045 ,  A61K9/0065 ,  A61M5/14276 ,  A61M39/0208 ,  A61M2210/106 ,  A61M2210/1064 ,  A61N1/0509 ,  A61N1/36007 ,  A61N1/37205

摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems and ingestible pills. In one embodiment, a method of producing satiety comprising the steps of accessing a gastrointestinal tract of a patient and implanting an intraintestinal therapeutic substance eluting implant. The implant is capable of eluting a satiety inducing substance selected from at least one of a nutrient, a specific satiety inducing bio-active substance, pancreatic polypeptides, free fatty acids, cholecystokinin, amino acids, glutamine, lipids, linoleic acid, or a combination thereof, from the implant into the gastrointestinal tract.

摘要翻译： 方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。 这些方法和装置通过稳定的可植入系统和可摄取的药丸来实现。 在一个实施方案中，产生饱腹感的方法包括以下步骤：进入患者的胃肠道并植入肠内治疗物质洗脱植入物。 植入物能够洗脱选自营养物，特定饱腹感生物活性物质，胰腺多肽，游离脂肪酸，缩胆囊素，氨基酸，谷氨酰胺，脂质，亚油酸或组合中的至少一种的饱腹感受物质 从植入物到胃肠道。

公开(公告)号：US08603023B2

公开(公告)日：2013-12-10

申请号：US13105029

申请日：2011-05-11

申请人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, Jr. ,  Jason L. Harris ,  Christopher J. Hess ,  Thomas W. Huitema ,  John V. Hunt ,  Prasanna Malaviya ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  Foster B. Stulen ,  James W. Voegele ,  William B. Weisenburgh, II ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, Jr. ,  David C. Yates ,  Mark S. Zeiner ,  Andrew M. Zwolinski

发明人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, Jr. ,  Jason L. Harris ,  Christopher J. Hess ,  Thomas W. Huitema ,  John V. Hunt ,  Prasanna Malaviya ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  Foster B. Stulen ,  James W. Voegele ,  William B. Weisenburgh, II ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, Jr. ,  David C. Yates ,  Mark S. Zeiner ,  Andrew M. Zwolinski

IPC分类号： A61M5/00 ,  A61M29/00

CPC分类号： A61F5/0076 ,  A61F2/04 ,  A61F5/0013 ,  A61F5/0026 ,  A61F5/0079 ,  A61F2002/045

摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems, and ingestible pills. In one embodiment, the implantable system comprises a device delivering a therapeutic substance to a target location within the gastrointestinal tract of a patient in order to initiate an intestinal braking effect which would promote sensations of satiety and stimulate excess weight loss for the patient.

摘要翻译： 方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。 这些方法和装置通过稳定的可植入系统和可摄取的药丸来实现。 在一个实施方案中，可植入系统包括将治疗物质递送到患者胃肠道内的目标位置的装置，以便开始肠促动作用，其将促进饱腹感，并刺激患者多余的体重减轻。

公开(公告)号：US08636751B2

公开(公告)日：2014-01-28

申请号：US13104192

申请日：2011-05-10

申请人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, Jr. ,  Jason L. Harris ,  Christopher J. Hess ,  Kevin L. Houser ,  Mario Gutierrez ,  Prasanna Malaviya ,  Amy L. Marcotte ,  Jeffrey D. Messerly ,  Anthony Nguyen ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  Foster B. Stulen ,  James W. Voegele ,  Lauren S. Weaner ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, Jr. ,  Mark S. Zeiner

发明人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, Jr. ,  Jason L. Harris ,  Christopher J. Hess ,  Kevin L. Houser ,  Mario Gutierrez ,  Prasanna Malaviya ,  Amy L. Marcotte ,  Jeffrey D. Messerly ,  Anthony Nguyen ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  Foster B. Stulen ,  James W. Voegele ,  Lauren S. Weaner ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, Jr. ,  Mark S. Zeiner

IPC分类号： A61B17/10

CPC分类号： A61B17/00234 ,  A61B5/0031 ,  A61B5/036 ,  A61B5/073 ,  A61B5/076 ,  A61B5/1107 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/42 ,  A61B17/0469 ,  A61B17/1114 ,  A61B2017/00876 ,  A61B2017/1117 ,  A61B2017/1139 ,  A61B2560/0219 ,  A61F2/04 ,  A61F5/0013 ,  A61F2002/045

摘要： Methods and devices reroute chyme to induce intestinal brake in order to improve the effectiveness of bariatric surgical procedures and to improve comorbidity resolution. A bowel is manipulated to provide a shortened path for chyme to travel to the ileum. These methods and devices of rerouting chyme to induce intestinal brake may include one or more of a surgical procedure, an implanted device, or a combination of an implant with an improved surgical procedure.

摘要翻译： 方法和装置重新路由食糜诱导肠道制动，以提高减肥手术的有效性和改善共病分解。 肠道被操纵以提供用于食糜行进到回肠的缩短路径。 用于诱导肠内制动器的这些重新路由食糜的方法和装置可以包括外科手术，植入装置或具有改进的外科手术的植入物的组合中的一种或多种。

公开(公告)号：US20120165796A1

公开(公告)日：2012-06-28

申请号：US12976726

申请日：2010-12-22

申请人： Mark S. Ortiz ,  Christopher J. Hess ,  Jason L. Harris ,  James W. Voegele ,  William B. Weisenburgh, II ,  Mark S. Zeiner ,  Mark D. Overmyer

发明人： Mark S. Ortiz ,  Christopher J. Hess ,  Jason L. Harris ,  James W. Voegele ,  William B. Weisenburgh, II ,  Mark S. Zeiner ,  Mark D. Overmyer

IPC分类号： A61M31/00

CPC分类号： A61M31/002 ,  A61B1/041

摘要： Devices and related methods are provided for the controlled delivery of a therapeutic to a targeted location within a body. More particularly, methods and devices are provided for controlling the rate of passage of an orally administered pill through a body, as well as for controlling the delivery of a therapeutic within the pill at a specific location within the body. Various types of devices, generally referred to herein as “catchers,” are provided that can actively catch a pill as it passes through a body. The catcher can hold the pill at a specific location within the body until a predetermined event occurs, such as partial or complete administration of a therapeutic within the pill. The catcher can then release the pill upon command and/or upon the occurrence of the predetermined event to allow the pill to pass out of the body. In other embodiments, various types of pills are provided that can actively engage a catcher and remain engaged with the catcher until a predetermined event occurs.

公开(公告)号：US20110295185A1

公开(公告)日：2011-12-01

申请号：US13104313

申请日：2011-05-10

申请人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, JR. ,  Jason L. Harris ,  Christopher J. Hess ,  Prasanna Malaviya ,  Glenda C. Marsh ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  James W. Voegele ,  Lauren S. Weaner ,  William B. Weisenburgh, II ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, JR. ,  David C. Yates ,  Mark S. Zeiner ,  Andrew M. Zwolinski

发明人： Thomas E. Albrecht ,  Jeffrey L. Aldridge ,  Sean P. Conlon ,  Michael S. Cropper ,  Denzel Z. Herrera-Davis ,  Daniel F. Dlugos, JR. ,  Jason L. Harris ,  Christopher J. Hess ,  Prasanna Malaviya ,  Glenda C. Marsh ,  Mark S. Ortiz ,  Mark D. Overmyer ,  Alessandro Pastorelli ,  Galen C. Robertson ,  Frederick E. Shelton, IV ,  Michael J. Stokes ,  James W. Voegele ,  Lauren S. Weaner ,  William B. Weisenburgh, II ,  Christopher W. Widenhouse ,  Tamara S. Vetro Widenhouse ,  James A. Woodard, JR. ,  David C. Yates ,  Mark S. Zeiner ,  Andrew M. Zwolinski

IPC分类号： A61M37/00 ,  A61K31/20 ,  A61M5/00 ,  A61F2/00 ,  A61M5/168 ,  A61N1/36

CPC分类号： A61M31/002 ,  A61F2/04 ,  A61F5/0013 ,  A61F5/0026 ,  A61F2002/045 ,  A61K9/0065 ,  A61M5/14276 ,  A61M39/0208 ,  A61M2210/106 ,  A61M2210/1064 ,  A61N1/0509 ,  A61N1/36007 ,  A61N1/37205

摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems and ingestible pills. In one embodiment, a method of producing satiety comprising the steps of accessing a gastrointestinal tract of a patient and implanting an intraintestinal therapeutic substance eluting implant. The implant is capable of eluting a satiety inducing substance selected from at least one of a nutrient, a specific satiety inducing bio-active substance, pancreatic polypeptides, free fatty acids, cholecystokinin, amino acids, glutamine, lipids, linoleic acid, or a combination thereof, from the implant into the gastrointestinal tract.

摘要翻译： 方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。 这些方法和装置通过稳定的可植入系统和可摄取的药丸来实现。 在一个实施方案中，产生饱腹感的方法包括以下步骤：进入患者的胃肠道并植入肠内治疗物质洗脱植入物。 植入物能够洗脱选自营养物，特定饱腹感生物活性物质，胰腺多肽，游离脂肪酸，缩胆囊素，氨基酸，谷氨酰胺，脂质，亚油酸或组合中的至少一种的饱腹感受物质 从植入物到胃肠道。