Hexahydroimidazopyrazin-3-one compounds useful as modulators of androgen receptor function
    9.
    发明申请
    Hexahydroimidazopyrazin-3-one compounds useful as modulators of androgen receptor function 有权
    六氢咪唑并吡嗪-3-酮化合物可用作雄激素受体功能的调节剂

    公开(公告)号:US20070088039A1

    公开(公告)日:2007-04-19

    申请号:US11546965

    申请日:2006-10-12

    IPC分类号: A61K31/498 C07D487/04

    CPC分类号: C07D487/04

    摘要: The present invention is directed to compounds having the formula (I), and/or pharmaceutically-acceptable salts thereof, useful in the treatment of androgen-receptor associated conditions, wherein Ar is aryl, substituted aryl, heteroaryl, or substituted heteroaryl; L is a linker as defined in the specification; R1 may be hydrogen, cyano, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocyclo, substituted heterocyclo, heteroaryl, or substituted heteroaryl, as defined in the specification; R2 is hydrogen, lower alkyl, or substituted lower alkyl; and R3, R4 and R5 are optionally non-interfering substituents as defined in the specification.

    摘要翻译: 本发明涉及可用于治疗雄激素受体相关病症的式(I)化合物和/或其药学上可接受的盐,其中Ar为芳基,取代的芳基,杂芳基或取代的杂芳基; L是说明书中定义的接头; R 1可以是如本说明书中定义的氢,氰基,烷基,取代的烷基,芳基,取代的芳基,环烷基,取代的环烷基,杂环,取代的杂环,杂芳基或取代的杂芳基; R 2是氢,低级烷基或取代的低级烷基; 并且R 3,R 4和R 5可以是说明书中定义的任选的非干扰性取代基。