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公开(公告)号:US20060223832A1
公开(公告)日:2006-10-05
申请号:US10917031
申请日:2004-08-12
申请人: Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
发明人: Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
IPC分类号: A61K31/497 , C07D487/14
CPC分类号: C07D487/18 , A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07B2200/11 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D491/22 , C07D495/08 , C07D495/18 , C07D519/00 , C40B40/00 , A61K2300/00
摘要: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
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公开(公告)号:US20060264459A1
公开(公告)日:2006-11-23
申请号:US11338587
申请日:2006-02-15
申请人: Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
发明人: Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
IPC分类号: A61K31/4709 , A61K31/407 , C07D491/02
CPC分类号: C07D487/18
摘要: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
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3.Fused Heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 失效
标题翻译: 融合的杂环琥珀酰亚胺化合物及其类似物,核激素受体功能的调节剂公开(公告)号:US20050272799A1
公开(公告)日:2005-12-08
申请号:US11176810
申请日:2005-07-07
申请人: Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
发明人: Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
IPC分类号: A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D471/18 , C07D487/08 , C07D487/18 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00
CPC分类号: C07D487/18 , A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07B2200/11 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D491/22 , C07D495/08 , C07D495/18 , C07D519/00 , C40B40/00 , A61K2300/00
摘要: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
摘要翻译: 稠合的环状化合物,使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法,以及含有这些化合物的药物组合物。
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4.Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 有权
标题翻译: 稠合的杂环琥珀酰亚胺化合物及其类似物,核激素受体功能的调节剂公开(公告)号:US20050192253A1
公开(公告)日:2005-09-01
申请号:US10974049
申请日:2004-10-25
申请人: Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
发明人: Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
IPC分类号: A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D471/18 , C07D487/08 , C07D487/18 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00 , C07D487/14
CPC分类号: C07D487/18 , A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07B2200/11 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D491/22 , C07D495/08 , C07D495/18 , C07D519/00 , C40B40/00 , A61K2300/00
摘要: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
摘要翻译: 稠合的环状化合物,使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法,以及含有这些化合物的药物组合物。
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5.METHOD FOR THE PREPARATION OF FUSED HETEROCYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF 失效
标题翻译: 熔融杂环化合物化合物的制备方法及其模拟物公开(公告)号:US20050119228A1
公开(公告)日:2005-06-02
申请号:US10024878
申请日:2001-12-19
申请人: Mark Salvati , Toomas Mitt , Ramesh Patel , Ronald Hanson , David Brzozowski , Animesh Goswami , Linda Chu , Wen-sen Li , James Simpson , Michael Totleben , Weixuan He
发明人: Mark Salvati , Toomas Mitt , Ramesh Patel , Ronald Hanson , David Brzozowski , Animesh Goswami , Linda Chu , Wen-sen Li , James Simpson , Michael Totleben , Weixuan He
IPC分类号: A61K31/00 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D487/18 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00 , C07D487/14
CPC分类号: C07D487/18 , A61K31/00 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00 , A61K2300/00
摘要: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
摘要翻译: 稠合的环状化合物,使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法,以及含有这些化合物的药物组合物。
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6.STEREOSELECTIVE REDUCTION PROCESS FOR THE PREPARATION OF PYRROLOTRIAZINE COMPOUNDS 有权
标题翻译: 用于制备吡咯啉化合物的选择性缩合方法公开(公告)号:US20060286646A1
公开(公告)日:2006-12-21
申请号:US11421112
申请日:2006-05-31
申请人: Ramesh Patel , Linda Chu , Robert Johnson , Zhiwei Guo , Yijun Chen , Steven Goldberg , Ronald Hanson , Animesh Goswami , Kishta Katipally
发明人: Ramesh Patel , Linda Chu , Robert Johnson , Zhiwei Guo , Yijun Chen , Steven Goldberg , Ronald Hanson , Animesh Goswami , Kishta Katipally
IPC分类号: C12P17/16 , C07D487/04
CPC分类号: C12N9/0006 , C07D487/04 , C12P17/165
摘要: The invention relates to a process for the enzymatic, stereoselective reduction of ketone compounds to provide chiral alcohols, for example the compound of formula Ib:
摘要翻译: 本发明涉及一种用于酶促立构选择性还原酮化合物以提供手性醇的方法,例如式Ib化合物:
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7.Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof 有权
标题翻译: 二肽基肽酶IV抑制剂的生产方法和化合物及其中间体公开(公告)号:US20050090539A1
公开(公告)日:2005-04-28
申请号:US10716012
申请日:2003-11-18
申请人: Truc Vu , David Brzozowski , Rita Fox , Jollie Godfrey , Ronald Hanson , Sergei Kolotuchin , John Mazzullo , Ramesh Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason Zhu , David Magnin , David Augeri , Lawrence Hamann
发明人: Truc Vu , David Brzozowski , Rita Fox , Jollie Godfrey , Ronald Hanson , Sergei Kolotuchin , John Mazzullo , Ramesh Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason Zhu , David Magnin , David Augeri , Lawrence Hamann
IPC分类号: A61K31/403 , A61K31/435 , C07C62/06 , C07C69/00 , C07C69/716 , C07C229/28 , C07C271/22 , C07D20060101 , C07D201/00 , C07D207/22 , C07D207/277 , C07D209/02 , C07D209/52 , C07D221/02
CPC分类号: C07C69/757 , C07C62/06 , C07C69/635 , C07C69/675 , C07C229/28 , C07C271/22 , C07C2603/74 , C07D207/22 , C07D209/52
摘要: Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
摘要翻译: 提供了用于制备二肽基肽酶IV的环丙基稠合吡咯烷基抑制剂的方法和化合物。
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8.Enzymatic ammonolysis process for the preparation of intermediates for DPP IV inhibitors 有权
标题翻译: 用于制备DPP IV抑制剂中间体的酶促氨解过程公开(公告)号:US20050256019A1
公开(公告)日:2005-11-17
申请号:US11119552
申请日:2005-05-02
申请人: Ramesh Patel , Ronald Hanson , Iqbal Gill , David Brzozowski , Paul Skonezny , Michael Politino , Jason Chen , Francisco Moris-Varas , Brenda White
发明人: Ramesh Patel , Ronald Hanson , Iqbal Gill , David Brzozowski , Paul Skonezny , Michael Politino , Jason Chen , Francisco Moris-Varas , Brenda White
IPC分类号: C07D207/22 , C07D209/52 , C07K5/065 , C11D3/00 , C12P17/10
CPC分类号: C07D207/22 , C07D209/52 , C07K5/06078 , C12P13/04 , C12P17/10 , C12P17/12
摘要: An enzymatic ammonolysis process is provided for the preparation of intermediates used in preparing dipeptidyl peptidase IV inhibitors wherein the enzyme Candida antarctica lipase-B is used to catalyze the ammonolysis process.
摘要翻译: 提供酶促氨解方法用于制备用于制备二肽基肽酶IV抑制剂的中间体,其中使用南极假丝酵母脂肪酶-B来催化氨解过程。
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公开(公告)号:US06468781B1
公开(公告)日:2002-10-22
申请号:US09510925
申请日:2000-02-22
申请人: Ronald Hanson , Mary Jo Donovan , Steven Goldberg , Paul A. Jass , Wen-Sen Li , Ramesh Patel , Keith Ramig , Laszlo J. Szarka , John J. Venit
发明人: Ronald Hanson , Mary Jo Donovan , Steven Goldberg , Paul A. Jass , Wen-Sen Li , Ramesh Patel , Keith Ramig , Laszlo J. Szarka , John J. Venit
IPC分类号: C12P2106
CPC分类号: C12N9/0018 , C12N9/0008 , C12P7/62 , C12P41/002 , C12P41/006
摘要: Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.
摘要翻译: 描述了某些酮羧酸衍生物立体选择性酶转化以形成相应的烷基氨基酸化合物的方法。 本发明还涉及包含能够表达苯丙氨酸脱氢酶的重组核酸的工程酵母宿主细胞,以及含有能够表达苯丙氨酸脱氢酶的重组核酸和能够表达甲酸脱氢酶的核酸的工程化宿主细胞。
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10.ENZYMATIC PREPARATION OF (S) AMINO ACID FROM (R,S) AMINO ACID OR FROM KETO ACID 审中-公开
标题翻译: (R,S)氨基酸或酮酸的(S)氨基酸的酶促制备公开(公告)号:US20070231858A1
公开(公告)日:2007-10-04
申请号:US11690159
申请日:2007-03-23
申请人: Ramesh Patel , Yijun Chen , Steven Goldberg , Iqbal Gill , Animesh Goswami , Thomas Tully , William Parker , Ronald Hanson
发明人: Ramesh Patel , Yijun Chen , Steven Goldberg , Iqbal Gill , Animesh Goswami , Thomas Tully , William Parker , Ronald Hanson
IPC分类号: C12P21/06 , C12P13/04 , C12N9/90 , C07D213/55
CPC分类号: C12N9/1096 , C07D213/55 , C12N9/0016 , C12P13/04 , C12P17/12 , C12P41/002
摘要: Disclosed and claimed herein are novel biocatalysts for converting racemic mixtures of amino acids to an enantiomerically pure (S) form of the amino acid, methods for their use, and the enantiomerically enriched products of such biocatalytic processes.
摘要翻译: 本文公开和要求保护的是用于将氨基酸的外消旋混合物转化为对映体纯的(S)形式的氨基酸的新型生物催化剂,其使用方法以及这些生物催化方法的对映异构体富集的产物。
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