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公开(公告)号:US20050282813A1
公开(公告)日:2005-12-22
申请号:US11168223
申请日:2005-06-28
申请人: Mark Salvati , James Balog , Weifang Shan , Soren Giese , Lalgudi Harikrishnan
发明人: Mark Salvati , James Balog , Weifang Shan , Soren Giese , Lalgudi Harikrishnan
IPC分类号: A61K31/00 , A61K31/407 , A61K31/498 , A61K31/655 , A61K31/675 , C07D471/18 , C07D487/08 , C07D487/14 , C07D487/18 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00
CPC分类号: C07D487/08 , A61K31/00 , A61K31/407 , A61K31/655 , A61K31/675 , C07D487/14 , A61K2300/00
摘要: The invention pertains to fused cyclic compounds having the formula, wherein G is an optionally substituted aryl or heterocyclo, L is an optional linker, M is a bond, O, CR7R7′ or NR10, and M′ is a bond or NR10, with the proviso that at least one of M or M′ must be a bond; E is C=Z2, CR7CR7′, SO2, P═OR2, or P═OOR2; Z1 is O, S, NH, or NR6; Z2 is O, S, NH, or NR6; A1 is CR7 or N; A2 is CR7 or N; Y is J-J′-J″ where J is (CR7R7′)n and n=0-3, J′ is a bond or O, S, S═O, SO2, NH, NR6, C═O, OC═O, NR1C═O, CR7R7′, C═CR8R8′, R2P═O, OPOOR2, OPO2, OSO2, C═N, NHNH, NHNR6, NR6NH, N=N, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo or substituted heterocyclo or aryl or substituted aryl, and J″ is (CR7R7′)n and n=0-3; and W, Q, R2, R6, R7, R7′, R8, R8′, R9, R9′, and R10 are as defined in the specification and/or claims herein, to methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and to pharmaceutical compositions containing such compounds.
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公开(公告)号:US20070161685A1
公开(公告)日:2007-07-12
申请号:US11559930
申请日:2006-11-15
申请人: Mark Salvati , Heather Finlay , Lalgudi Harikrishnan , Ji Jiang , James Johnson , Muthoni Kamau , R. Lawrence , Michael Miller , Jennifer Qiao , Tammy Wang , Yufeng Wang , Wu Yang
发明人: Mark Salvati , Heather Finlay , Lalgudi Harikrishnan , Ji Jiang , James Johnson , Muthoni Kamau , R. Lawrence , Michael Miller , Jennifer Qiao , Tammy Wang , Yufeng Wang , Wu Yang
IPC分类号: A61K31/44 , C07D213/56
CPC分类号: C07D417/06 , C07D213/40 , C07D213/61 , C07D277/28 , C07D401/04 , C07D401/12 , C07D405/06 , C07D405/12 , C07D417/12
摘要: Compounds of formula Ia and Ib wherein A, B, C and R1 are described herein.
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公开(公告)号:US20070135631A1
公开(公告)日:2007-06-14
申请号:US11558979
申请日:2006-11-13
申请人: Mark Salvati , Heather Finlay , Bang-Chi Chen , Lalgudi Harikrishnan , Ji Jiang , James Johnson , Muthoni Kamau , R. Lawrence , Jianqing Li , John Lloyd , Michael Miller , Zulan Pi , Jennifer Qiao , Richard Rampulla , Jacques Roberge , Tammy Wang , Yufeng Wang , Wu Yang
发明人: Mark Salvati , Heather Finlay , Bang-Chi Chen , Lalgudi Harikrishnan , Ji Jiang , James Johnson , Muthoni Kamau , R. Lawrence , Jianqing Li , John Lloyd , Michael Miller , Zulan Pi , Jennifer Qiao , Richard Rampulla , Jacques Roberge , Tammy Wang , Yufeng Wang , Wu Yang
IPC分类号: C07D257/02 , C07C237/38
CPC分类号: C07C275/26 , C07C211/29 , C07C215/08 , C07C217/58 , C07C229/36 , C07C229/38 , C07C233/09 , C07C233/13 , C07C233/18 , C07C233/56 , C07C233/60 , C07C233/66 , C07C233/73 , C07C233/78 , C07C235/20 , C07C235/34 , C07C235/48 , C07C235/74 , C07C237/06 , C07C237/08 , C07C251/38 , C07C255/13 , C07C255/57 , C07C255/60 , C07C271/16 , C07C271/20 , C07C271/44 , C07C275/24 , C07C311/04 , C07C311/17 , C07C317/44 , C07C323/57 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/08 , C07D207/10 , C07D207/16 , C07D207/26 , C07D207/273 , C07D207/325 , C07D207/38 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/48 , C07D211/38 , C07D211/58 , C07D213/38 , C07D213/40 , C07D213/82 , C07D231/14 , C07D231/40 , C07D239/26 , C07D249/04 , C07D249/06 , C07D249/08 , C07D249/14 , C07D257/04 , C07D257/06 , C07D261/04 , C07D261/08 , C07D261/14 , C07D261/18 , C07D263/34 , C07D271/06 , C07D271/10 , C07D271/113 , C07D277/48 , C07D277/58 , C07D277/60 , C07D285/06 , C07D285/135 , C07D295/155 , C07D303/48 , C07D307/22 , C07D307/24 , C07D307/33 , C07D307/68 , C07D307/79 , C07D307/85 , C07D311/58 , C07D317/46 , C07D319/20 , C07D333/20 , C07D333/24 , C07D333/38 , C07D333/68 , C07D333/70 , C07D471/04 , C07F7/081
摘要: Compounds of formula Ia and Ib wherein A, B, C and R1 are described herein.
摘要翻译: 其中A,B,C和R 1'的式Ia和Ib化合物在本文中描述。
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