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32 条记录 (耗时 0.039 秒)

    Fuel composition
    5.
    发明授权
    Fuel composition 有权
    燃油组成

    公开(公告)号：US07553404B2

    公开(公告)日：2009-06-30

    申请号：US11980821

    申请日：2007-10-31

    申请人： Alisdair Quentin Clark ,  Philip Howard ,  Anthony George William Parker

    发明人： Alisdair Quentin Clark ,  Philip Howard ,  Anthony George William Parker

    IPC分类号： C10G7/02

    CPC分类号： C10L1/023 ,  C10L1/02 ,  C10L1/04 ,  C10L1/06

    摘要： A process for preparing at least two compositions suitable for production of gasoline, which process comprises: fractionating an alkylation product to produce a first cut boiling in the range 90-106° C., a second cut boiling at temperature lower than said first cut, and a third cut boiling at a temperature above said first Cut, blending at least 2% by volume of said first cut with at least 5% of a component selected from at least one of a paraffin, an aromatic hydrocarbon and an olefinic hydrocarbon, said component having a boiling point of 60-160° C., wherein not more than 5% of the total composition of hydrocarbon has a boiling point of more than 160° C. and wherein said composition comprises less than 5% of 2,2,3-trimethylbutane or 2,2,3-trimethylpentane, to produce a first high octane unleaded gasoline composition of RON at least 97 and MON value at least 86, and incorporating said second and third cuts with said component to produce a second high octane unleaded gasoline composition of RON at least 92 and MON value at least 80.

    摘要翻译： 一种制备适于生产汽油的至少两种组合物的方法，该方法包括：分馏烷基化产物以产生在90-106℃范围内的第一次沸腾，在低于所述第一次切割的温度下进行第二次沸腾， 和在高于所述第一馏分的温度下沸腾的第三馏分，将至少2体积％的所述第一馏分与至少5％的选自至少一种石蜡，芳族烃和烯烃的组分共混，所述 沸点为60-160℃的组分，其中不超过组合物总组合物的5％具有大于160℃的沸点，并且其中所述组合物包含少于5重量％的2,2， 3-三甲基丁烷或2,2,3-三甲基戊烷，以产生至少97的RON的第一高辛烷值无铅汽油组合物，并且MON值至少为86，并且将所述第二和第三切割与所述组分并入以产生无铅的第二高辛烷值 汽油组合 RON至少为92，MON值至少为80。

    Pyrrolobenzodiazepines
    6.
    发明申请
    Pyrrolobenzodiazepines 有权
    吡咯并苯并二氮杂卓

    公开(公告)号：US20060148788A1

    公开(公告)日：2006-07-06

    申请号：US11367241

    申请日：2006-03-02

    申请人： David Thurston ,  Philip Howard

    发明人： David Thurston ,  Philip Howard

    IPC分类号： A61K31/551 ,  C07D487/02

    CPC分类号： C07D487/04

    摘要： A compound of the formula II: wherein: R′2 is CHR″2, where R″2 is H. R6 and R9 are H and R7 is OMe and the compound is a dimer with each monomer being the same and being of formula II, where the R8 groups of the monomers form together a bridge having the formula —O—(CH2)p—O—, where p is 5, linking the monomers.

    摘要翻译： 式II的化合物：其中：R'2是CHR“2，其中R”2是H.R 6和R 9是H，R 7是OMe，并且化合物是每个单体相同并且是式II的二聚体，其中 单体的R 8基团一起形成具有式-O-（CH 2 CH 2）p -O-的桥，其中p为5 ，连接单体。

    Polymerization process
    7.
    发明授权
    Polymerization process 失效
    聚合过程

    公开(公告)号：US06300437B1

    公开(公告)日：2001-10-09

    申请号：US08904437

    申请日：1997-07-31

    申请人： Philip Howard ,  Peter James Maddox ,  Stephen Roy Partington

    发明人： Philip Howard ,  Peter James Maddox ,  Stephen Roy Partington

    IPC分类号： C08F442

    CPC分类号： C08F210/16 ,  C08F4/65912 ,  C08F4/65916 ,  C08F4/65927 ,  C08F10/00 ,  Y10S526/901 ,  Y10S526/943 ,  C08F210/14 ,  C08F2500/09 ,  C08F2500/20 ,  C08F2500/12 ,  C08F2500/26

    摘要： A process for preparing polyolefins having at least 0.01 long chain branches (LCB)/1000 carbon atoms along the polymer backbone as measured by flow activation and a molecular weight distribution greater than 2.5 comprises polymerization in the presence of a metallocene complex having the formula: wherein Cp1, Cp2 are independently a substituted or unsubstituted indenyl or hydrogenated indenyl group, Y is a univalent anionic ligand, M is zirconium, titanium or hafnium, and Z is a bridging group comprising an alkylene group having 1 to 20 carbon atoms or a dialkyl silyl- or germyl- group, or alkyl phophine or amine radical. Polyolefins prepared from such a process show specific flow activation energy/LCB relationships.

    摘要翻译： 通过流动活化和大于2.5的分子量分布测量，制备沿着聚合物主链具有至少0.01个长支链（LCB）/ 1000个碳原子的聚烯烃的方法包括在具有下式的茂金属络合物存在下聚合：其中Cp1 ，Cp2独立地是取代或未取代的茚基或氢化茚基，Y是一价阴离子配体，M是锆，钛或铪，Z是包含具有1至20个碳原子的亚烷基的桥连基或二烷基甲硅烷基或 甲锗烷基或烷基磷或胺基。 从这种方法制备的聚烯烃显示出特定的流动活化能/ LCB关系。

    11-Hydroxy-5h-pyrrolo[2,1-c][1,4] benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines
    10.
    发明申请
    11-Hydroxy-5h-pyrrolo[2,1-c][1,4] benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines 有权
    11-羟基-5H-吡咯并[2,1-c] [1,4]苯并二氮杂-5-酮衍生物作为制备c2取代的吡咯并苯并二氮杂的关键中间体

    公开(公告)号：US20070173497A1

    公开(公告)日：2007-07-26

    申请号：US10598518

    申请日：2005-03-01

    申请人： Philip Howard ,  Stephen Gregson

    发明人： Philip Howard ,  Stephen Gregson

    IPC分类号： A61K31/54

    CPC分类号： C07D487/04 ,  Y02P20/55

    摘要： The present inventors have developed a key intermediate for the production of C2 substituted PBDs, which has a leaving group at the C2 position, a carbamate protecting group at the N10 position and a protected hydroxy group at the C11 position. In a first aspect, the present invention comprises a compound with a the formula (I), wherein: R10 is a carbamate-based nitrogen protecting group; R11 is an oxygen protecting group; and R2 is a labile leaving group. In a further aspect, the present invention comprises a method of synthesising a compound of formula (III), or a solvate thereof, from a compound of formula (I) as defined in the first aspect, R16 is either O—R11, wherein R11 is as defined in the first aspect, or OH, or R10 and R16 together form a double bond between N10 and C11; and R15 is R. The other substituents are defined in the claims. Further aspects of the present invention relate to compounds of formula (III) (including solvates thereof when R10 and R16 form a double bond between N10 and C11, and pharmaceutical salts thereof), pharmaceutical compositions comprising these, and their use in the manufacture of a medicament for the treatment of a proliferative disease.

    摘要翻译： 本发明人已经开发了用于生产在C2位具有离去基团的C2取代的PBD的关键中间体，N10位的氨基甲酸酯保护基和C11位的被保护的羟基。 在第一方面，本发明包括具有式（I）的化合物，其中：R 10是氨基甲酸酯基氮保护基; R 11是氧保护基; R 2是不稳定的离去基团。 在另一方面，本发明包括由第一方面定义的式（I）化合物合成式（III）化合物或其溶剂化物的方法，其中R 16， 是O-R 11，其中R 11如在第一方面中所定义，或OH或R 10和R 16一起形成 N10和C11之间的双键; 并且R 15是R.其它取代基在权利要求中限定。 本发明的其它方面涉及式（III）的化合物（当R 10和R 16在N 10和C 11之间形成双键时，包括其溶剂合物，以及药物盐 ），包含它们的药物组合物及其在制备用于治疗增殖性疾病的药物中的用途。