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公开(公告)号:US08399468B2
公开(公告)日:2013-03-19
申请号:US12715660
申请日:2010-03-02
申请人: Marlon D. Cowart , Chen Zhao , Minghua Sun , Lawrence A. Black , Guo Zhu Zheng , Robert J. Gregg , Geoff G. Z. Zhang , Ahmad Y. Sheikh , Xiaochun Lou , Rodger F. Henry , David M. Barnes , Lawrence Kolaczkowski , Anthony R. Haight , Sou-Jen Chang , Steven J. Wittenberger , Michael G. Fickes
发明人: Marlon D. Cowart , Chen Zhao , Minghua Sun , Lawrence A. Black , Guo Zhu Zheng , Robert J. Gregg , Geoff G. Z. Zhang , Ahmad Y. Sheikh , Xiaochun Lou , Rodger F. Henry , David M. Barnes , Lawrence Kolaczkowski , Anthony R. Haight , Sou-Jen Chang , Steven J. Wittenberger , Michael G. Fickes
IPC分类号: A61K31/501 , C07D403/10
CPC分类号: C07D487/04
摘要: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.
摘要翻译: 八氢吡咯并[3,4-b]吡咯衍生物可用于治疗组胺-3受体配体预防或改善的病症或病症。 八氢吡咯并[3,4-b]吡咯化合物,使用这些化合物的方法,制备它们的组合物和制备这些化合物的方法在本文中公开。
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公开(公告)号:US20100222358A1
公开(公告)日:2010-09-02
申请号:US12715660
申请日:2010-03-02
申请人: Marlon D. Cowart , Chen Zhao , Minghua Sun , Lawrence A. Black , Guo Zhu Zheng , Robert J. Gregg , Geoff G.Z. Zhang , Ahmad Y. Sheikh , Xiaochun Lou , Rodger F. Henry , David M. Barnes , Lawrence Kolaczkowski , Anthony R. Haight , Sou-Jen Chang , Steven J. Wittenberger , Michael G. Fickes
发明人: Marlon D. Cowart , Chen Zhao , Minghua Sun , Lawrence A. Black , Guo Zhu Zheng , Robert J. Gregg , Geoff G.Z. Zhang , Ahmad Y. Sheikh , Xiaochun Lou , Rodger F. Henry , David M. Barnes , Lawrence Kolaczkowski , Anthony R. Haight , Sou-Jen Chang , Steven J. Wittenberger , Michael G. Fickes
IPC分类号: A61K31/501 , A61K31/407 , C07D487/04 , A61K31/47 , C07D215/00 , A61K31/4439 , C07D401/14 , A61K31/428 , C07D417/14 , A61K31/4164 , C07D233/00 , C07D403/14 , A61K31/506 , A61K31/497 , A61P3/04 , A61P5/00 , A61P11/06 , A61P25/00 , A61P29/00 , A61P37/08 , A61P1/02
CPC分类号: C07D487/04
摘要: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.
摘要翻译: 八氢吡咯并[3,4-b]吡咯衍生物可用于治疗组胺-3受体配体预防或改善的病症或病症。 八氢吡咯并[3,4-b]吡咯化合物,使用这些化合物的方法,制备它们的组合物和制备这些化合物的方法在本文中公开。
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公开(公告)号:US07728031B2
公开(公告)日:2010-06-01
申请号:US11674518
申请日:2007-02-13
申请人: Marlon D. Cowart , Chen Zhao , Minghua Sun , Lawrence A. Black , Guo Zhu Zheng , Robert J. Gregg , Lawrence Kolaczkowski
发明人: Marlon D. Cowart , Chen Zhao , Minghua Sun , Lawrence A. Black , Guo Zhu Zheng , Robert J. Gregg , Lawrence Kolaczkowski
IPC分类号: A61K31/407 , A61K31/496 , C07D403/10 , C07D487/02
CPC分类号: C07D487/04
摘要: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands, Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.
摘要翻译: 八氢 - 吡咯并[3,4-b]吡咯衍生物可用于治疗组胺-3受体配体,八氢吡咯并[3,4-b]吡咯化合物,使用这些化合物的方法,组合物 制备这些化合物的方法和方法。
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公开(公告)号:US20070232612A1
公开(公告)日:2007-10-04
申请号:US11674518
申请日:2007-02-13
申请人: Marlon Cowart , Chen Zhao , Minghua Sun , Lawrence Black , Guo Zheng , Robert Gregg , Geoff Zhang , Ahmand Sheikh , Xiaochun Lou , Rodger Henry , David Barnes , Lawrence Kolaczkowski , Anthony Haight , Sou-Jen Chang , Steven Wittenberger , Michael Fickes
发明人: Marlon Cowart , Chen Zhao , Minghua Sun , Lawrence Black , Guo Zheng , Robert Gregg , Geoff Zhang , Ahmand Sheikh , Xiaochun Lou , Rodger Henry , David Barnes , Lawrence Kolaczkowski , Anthony Haight , Sou-Jen Chang , Steven Wittenberger , Michael Fickes
IPC分类号: A61K31/506 , A61K31/501 , A61K31/496 , A61K31/4439 , A61K31/407 , C07D487/02 , A61K31/416
CPC分类号: C07D487/04
摘要: Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands, Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.
摘要翻译: 八氢 - 吡咯并[3,4-b]吡咯衍生物可用于治疗组胺-3受体配体,八氢吡咯并[3,4-b]吡咯化合物,使用这些化合物的方法,组合物 制备这些化合物的方法和方法。
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公开(公告)号:US08592467B2
公开(公告)日:2013-11-26
申请号:US12489269
申请日:2009-06-22
申请人: Marlon D. Cowart , Minghua Sun , Chen Zhao , Guo Zhu Zheng
发明人: Marlon D. Cowart , Minghua Sun , Chen Zhao , Guo Zhu Zheng
IPC分类号: A61K31/428 , C07D277/62
CPC分类号: C07D277/64 , C07D417/04 , C07D417/08 , C07D417/12 , C07D487/04
摘要: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
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公开(公告)号:US20090326222A1
公开(公告)日:2009-12-31
申请号:US12489269
申请日:2009-06-22
申请人: Marlon D. Cowart , Minghua Sun , Chen Zhao , Guo Zhu Zheng
发明人: Marlon D. Cowart , Minghua Sun , Chen Zhao , Guo Zhu Zheng
IPC分类号: C07D413/14 , C07D417/14 , C07D401/14 , C07D277/62 , C07D237/02 , C07D213/02
CPC分类号: C07D277/64 , C07D417/04 , C07D417/08 , C07D417/12 , C07D487/04
摘要: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译: 式(I)化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物,使用这些化合物和组合物的方法,以及制备式(I)范围内的化合物的方法。
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公开(公告)号:US07576110B2
公开(公告)日:2009-08-18
申请号:US11518132
申请日:2006-09-08
申请人: Marlon D. Cowart , Minghua Sun , Chen Zhao , Guo Zhu Zheng
发明人: Marlon D. Cowart , Minghua Sun , Chen Zhao , Guo Zhu Zheng
IPC分类号: A61K31/428 , C07D277/62
CPC分类号: C07D277/64 , C07D417/04 , C07D417/08 , C07D417/12 , C07D487/04
摘要: Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译: 式(I)化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物,使用这些化合物和组合物的方法,以及制备式(I)范围内的化合物的方法。
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公开(公告)号:US07985745B2
公开(公告)日:2011-07-26
申请号:US11863925
申请日:2007-09-28
申请人: Marlon D. Cowart , Robert J. Altenbach , Huaqing Liu , Irene Drizin , Neil Wishart , David J. Babinski , Robert J. Gregg , Arthur A. Hancock , Kathryn J. Hancock, legal representative , Timothy A. Esbenshade , Gin C. Hsieh , Jorge D. Brioni , Marie P. Honore , Lawrence A. Black , Chen Zhao , Brian D. Wakefield
发明人: Marlon D. Cowart , Robert J. Altenbach , Huaqing Liu , Irene Drizin , Neil Wishart , David J. Babinski , Robert J. Gregg , Arthur A. Hancock , Timothy A. Esbenshade , Gin C. Hsieh , Jorge D. Brioni , Marie P. Honore , Lawrence A. Black , Chen Zhao , Brian D. Wakefield
IPC分类号: A61K31/395 , A61K31/495 , A61K31/498 , A61K31/502 , A61P25/00 , A61P25/02 , A61P19/02
CPC分类号: A61K31/506 , A61K31/417 , A61K31/496 , A61K45/06
摘要: This invention discloses a method of treating pain by administering histamine H4 receptor ligands and compositions comprising the same.
摘要翻译: 本发明公开了一种通过施用组胺H 4受体配体和包含其的组合物来治疗疼痛的方法。
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公开(公告)号:US20080194538A1
公开(公告)日:2008-08-14
申请号:US11863925
申请日:2007-09-28
申请人: Marlon D. Cowart , Robert J. Altenbach , Huaqing Liu , Irene Drizin , Neil Wishart , David J. Babinski , Robert J. Gregg , Arthur A. Hancock , Timothy A. Esbenshade , Gin C. Hsieh , Jorge D. Brioni , Marie P. Honore , Lawrence A. Black , Chen Zhao , Brian D. Wakefield , Kathryn J. Hancock
发明人: Marlon D. Cowart , Robert J. Altenbach , Huaqing Liu , Irene Drizin , Neil Wishart , David J. Babinski , Robert J. Gregg , Arthur A. Hancock , Timothy A. Esbenshade , Gin C. Hsieh , Jorge D. Brioni , Marie P. Honore , Lawrence A. Black , Chen Zhao , Brian D. Wakefield , Kathryn J. Hancock
IPC分类号: A61K31/397 , A61K31/506 , A61P25/00 , A61P25/02 , A61P19/02
CPC分类号: A61K31/506 , A61K31/417 , A61K31/496 , A61K45/06
摘要: This invention discloses a method of treating pain by administering histamine H4 receptor ligands and compositions comprising the same.
摘要翻译: 本发明公开了一种通过施用组胺H 4受体配体和包含其的组合物来治疗疼痛的方法。
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公开(公告)号:US20080188452A1
公开(公告)日:2008-08-07
申请号:US11863559
申请日:2007-09-28
申请人: Robert J. Altenbach , Huaqing Liu , Irene Drizin , Marlon D. Cowart , Neil Wishart , David J. Babinski , Robert J. Gregg , Arthur A. Hancock , Kathryn J. Hancock , Timothy A. Esbenshade , Gin C. Hsieh , Jorge D. Brioni , Marie P. Honore , Lawrence A. Black , Chen Zhao , Brian D. Wakefield
发明人: Robert J. Altenbach , Huaqing Liu , Irene Drizin , Marlon D. Cowart , Neil Wishart , David J. Babinski , Robert J. Gregg , Arthur A. Hancock , Kathryn J. Hancock , Timothy A. Esbenshade , Gin C. Hsieh , Jorge D. Brioni , Marie P. Honore , Lawrence A. Black , Chen Zhao , Brian D. Wakefield
IPC分类号: A61K31/517 , C07D487/10 , C07D471/10 , A61K31/55 , C07D487/04 , C07D471/04 , C07D403/04 , C07D403/14 , A61P29/00 , A61P37/00 , A61P25/00 , A61P35/00
CPC分类号: C07H17/04 , C07D239/70 , C07D403/12 , C07D453/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/04 , C07D495/04 , C07D519/00
摘要: Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.
摘要翻译: 本文描述了大环苯并菲的嘧啶化合物,包含这些化合物的组合物,制备该化合物的方法,以及使用这些化合物和组合物治疗和预防疾病进展,病症和病症的方法。
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