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    Anti-Aβ globulomer 5F7 antibodies
    5.
    发明授权
    Anti-Aβ globulomer 5F7 antibodies 有权
    反A＆BGR 球聚体5F7抗体

    公开(公告)号：US08691224B2

    公开(公告)日：2014-04-08

    申请号：US11574876

    申请日：2006-11-30

    申请人： Stefan Barghorn ,  Heinz Hillen ,  Boris Labkovsky ,  Andreas R. Striebinger ,  Patrick Keller ,  Ulrich Ebert

    发明人： Stefan Barghorn ,  Heinz Hillen ,  Boris Labkovsky ,  Andreas R. Striebinger ,  Patrick Keller ,  Ulrich Ebert

    IPC分类号： A61K39/00 ,  A61K39/395

    CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/4711 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821 ,  G01N2800/387

    摘要： Anti-Aβ globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies.The present invention relates to anti-Aβ globulomer antibodies having a binding affinity to Aβ(20-42) globulomer that is greater than the binding affinity of the antibody to Aβ(1-42) globulomer, antigen-binding moieties thereof, hybridomas producing said antibodies, nucleic acids encoding said antibodies, vectors comprising said nucleic acids, host cells comprising said vectors, methods of producing said antibodies, compositions comprising said antibodies, therapeutic and diagnostic uses of said antibodies and corresponding methods relating to Alzheimer's disease and other amyloidoses.

    摘要翻译： 反A＆BGR 球聚体抗体，其抗原结合部分，相应的杂交瘤，核酸，载体，宿主细胞，产生所述抗体的方法，包含所述抗体的组合物，所述抗体的用途和使用所述抗体的方法。 本发明涉及抗A＆Bgr; 具有与A＆Bgr（20-42）球聚体的结合亲和力的球聚体抗体，其大于抗体对Aβ和（1-42）球聚体，其抗原结合部分的结合亲和力，产生所述抗体的杂交瘤，编码所述抗体的核酸 包含所述核酸的载体，包含所述载体的宿主细胞，产生所述抗体的方法，包含所述抗体的组合物，所述抗体的治疗和诊断用途以及与阿尔茨海默病和其它淀粉样变性有关的相应方法。

    Aß(X - 38 .. 43) oligomers, and processes, compositions, and uses thereof
    7.
    发明申请
    Aß(X - 38 .. 43) oligomers, and processes, compositions, and uses thereof 审中-公开
    Aß（X-38.43）低聚物及其工艺，组合物和用途

    公开(公告)号：US20100173828A1

    公开(公告)日：2010-07-08

    申请号：US12509315

    申请日：2009-07-24

    申请人： Heinz Hillen ,  Andreas Striebinger ,  Simone Giaisi ,  Stefan Barghorn ,  Gerald Gellermann ,  Ulrich Ebert ,  Joerg Moelleken

    发明人： Heinz Hillen ,  Andreas Striebinger ,  Simone Giaisi ,  Stefan Barghorn ,  Gerald Gellermann ,  Ulrich Ebert ,  Joerg Moelleken

    IPC分类号： A61K38/17 ,  C07K14/435 ,  A61P25/28 ,  C40B30/04 ,  G01N33/53

    CPC分类号： C07K14/4711 ,  A61K39/0007 ,  A61K2039/55566 ,  C07K16/18 ,  G01N33/6896 ,  G01N2800/2821

    摘要： The present invention relates to an Aβ(X-38 . . . 43) oligomer having a high molecular weight, or a derivative thereof, a process for preparing the oligomer or derivative, compositions comprising the oligomer or derivative, and uses of the oligomer or derivative such as its use for treating or preventing an amyloidosis (e.g. by active immunization), for diagnosing an amyloidosis, and for providing agents that are capable of binding to the Aβ(X-38 . . . 43) oligomer or derivative. The subject invention also describes agents that are capable of binding to the Aβ(X-38 . . . 43) oligomer or derivative, e.g. antibodies, compositions comprising the agents, and uses of the agents such as their use for treating or preventing an amyloidosis (e.g. by passive immunization) and for diagnosing an amyloidosis.

    摘要翻译： 本发明涉及具有高分子量的A（b）（X-38.43）低聚物或其衍生物，制备低聚物或衍生物的方法，包含低聚物或衍生物的组合物，以及低聚物 或其衍生物，例如其用于治疗或预防淀粉样变性（例如通过主动免疫）用于诊断淀粉样变性的用途，以及用于提供能够与Aβ结合的试剂（X-38.43）寡聚体或衍生物。 本发明还描述了能够结合A和B（X-38.43）低聚物或衍生物的试剂。 抗体，包含该试剂的组合物，以及该药剂的用途，例如其用于治疗或预防淀粉样变性（例如通过被动免疫）和用于诊断淀粉样变性的用途。