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公开(公告)号:US5504095A
公开(公告)日:1996-04-02
申请号:US359709
申请日:1994-12-20
申请人: Masami Nakane , Kunio Satake , Kazuo Ando , Hiroaki Wakabayashi
发明人: Masami Nakane , Kunio Satake , Kazuo Ando , Hiroaki Wakabayashi
IPC分类号: C07D275/06 , C07D279/02 , C07D285/00 , C07D285/14 , C07D285/15 , C07D285/16 , C07D291/08 , C07D417/12 , C07D419/12 , A61K31/41
CPC分类号: C07D275/06 , C07D279/02 , C07D285/14 , C07D285/15 , C07D285/16 , C07D291/08 , C07D417/12 , C07D419/12
摘要: Aminobenzosultam derivatives, which are inhibitors of lipoxygenase, having the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein Ar is cycloalkyl having five to seven carbon atoms, tetrahydropyranyl, pyridyl, oxazolyl, phenyl or substituted phenyl wherein said substituent is methyl, methoxy, fluoro, chloro or trifluoromethyl; n is an integer of 1 to 3; X is hydrogen, methyl, methoxy, fluoro, chloro or trifluoromethyl; Z is --NH--, --O--, or --CH.sub.2 --; and R.sup.1 is hydrogen or alkyl having one to three carbon atoms.
摘要翻译: 作为脂氧合酶抑制剂的氨基苯并磺酰胺衍生物,其具有式
及其药学上可接受的酸加成盐,其中Ar是具有5-7个碳原子的环烷基,四氢吡喃基,吡啶基,恶唑基,苯基或取代的苯基,其中所述取代基是甲基 ,甲氧基,氟,氯或三氟甲基; n为1〜3的整数。 X是氢,甲基,甲氧基,氟,氯或三氟甲基; Z是-NH-,-O-或-CH 2 - ; 并且R 1是氢或具有1-3个碳原子的烷基。 -
公开(公告)号:US5716965A
公开(公告)日:1998-02-10
申请号:US175353
申请日:1993-12-20
IPC分类号: C07D453/02 , A61K31/445
CPC分类号: C07D453/02
摘要: Compounds of the formula ##STR1## wherein W, Ar.sup.1, Ar.sup.2 and Ar.sup.3 are defined as below; and the pharmaceutically acceptable salts of such compounds. These compounds are substance P antagonists and useful in the treatment of gastrointestinal disorders, inflammatory disorders, central nervous system disorders and pain.
摘要翻译: PCT No.PCT / US92 / 04002 Sec。 371日期:1993年12月20日 102(e)1993年12月20日日期PCT提交1992年5月19日PCT公布。 出版物WO92 / 20676 日期:1992年11月26日其中W,Ar 1,Ar 2和Ar 3如下定义的式(Ⅰ)化合物: 和这些化合物的药学上可接受的盐。 这些化合物是物质P拮抗剂,可用于治疗胃肠道疾病,炎性疾病,中枢神经系统疾病和疼痛。
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公开(公告)号:US5569662A
公开(公告)日:1996-10-29
申请号:US313289
申请日:1994-10-03
申请人: Kunio Satake , Hiroaki Wakabayashi , Masami Nakane
发明人: Kunio Satake , Hiroaki Wakabayashi , Masami Nakane
IPC分类号: C07D453/02 , A61K31/445
CPC分类号: C07D453/02
摘要: Compounds useful in the treatment of inflammatory disorders, central nervous system disorders and other disorders of formula (I) and the pharmaceutically-acceptable salts thereof, wherein X.sup.1 is alkoxy or halosubstituted alkoxy; X.sup.2 is hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, halosubstitued alkyl, halosubstituted alkoxy, alkylamino, dialkylamino, alkylsulfonylamino (which may be substituted), N-alkyl-N-alkylsulfonylamino (which may be substituted), alkanoylamino (which may be substituted) or N-alkyl-N-alkanoylamino (which may be substituted); Ar.sup.1 and Ar.sup.2 are each, independently, thienyl, phenyl, fluorophenyl, chlorophenyl or bromophenyl; A is Y--(CH.sub.2).sub.m --CH(R.sup.2)--(CH.sub.2).sub.n --NR.sup.1 --; R.sup.1 is hydrogen, alkyl, benzyl or --(CH.sub.2).sub.p --Y; R.sup.2 is hydrogen, alkyl (which may be substituted), benzyl, 4-hydroxybenzyl, 3-indolylmethyl or --(CH.sub.2).sub.p --Y; Y is --CN, --CH.sub.2 Z or --COZ; Z is hydroxy, amino, alkoxy, alkylamino or dialkylamino; m, n and p are each, independently, 0, 1, 2 or 3; and R.sup.1 and R.sup.2 may be connected to form a ring.
摘要翻译: PCT No.PCT / US93 / 01810 Sec。 371日期:1994年10月3日 102(e)日期1994年10月3日PCT 1993年3月5日PCT公布。 WO93 / 19064 PCT公开号 日期1993年9月30日可用于治疗炎症性疾病,中枢神经系统疾病和式(I)的其它病症及其药学上可接受的盐的化合物,其中X1是烷氧基或卤代取代的烷氧基; X 2是氢,卤素,烷基,烯基,炔基,烷氧基,烷硫基,烷基亚磺酰基,烷基磺酰基,卤素取代的烷基,卤代烷氧基,烷基氨基,二烷基氨基,烷基磺酰基氨基(其可被取代的),N-烷基-N-烷基磺酰基氨基 ),烷酰基氨基(其可以被取代)或N-烷基-N-烷酰基氨基(其可以被取代); Ar1和Ar2各自独立地为噻吩基,苯基,氟苯基,氯苯基或溴苯基; A是Y-(CH 2)m -CH(R 2) - (CH 2)n -NR 1; R1是氢,烷基,苄基或 - (CH2)p-Y; R 2是氢,烷基(其可以被取代),苄基,4-羟基苄基,3-吲哚基甲基或 - (CH 2)p-Y; Y是-CN,-CH2Z或-COZ; Z是羟基,氨基,烷氧基,烷基氨基或二烷基氨基; m,n和p各自独立地为0,1,2或3; 并且R1和R2可以连接形成环。
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公开(公告)号:US5852038A
公开(公告)日:1998-12-22
申请号:US950043
申请日:1996-11-18
IPC分类号: C07D453/02 , A61K31/445
CPC分类号: C07D453/02
摘要: ##STR1## Compounds of formula (1), wherein W, Ar
1 , Ar
2 and Ar
3 are defined as below; and the pharmaceutically acceptable salts of such compounds. These compounds are substance P antagonists and useful in the treatment of gastrointestinal disorders, inflammatory disorders, central nervous system disorders and pain.摘要翻译: (I)式(1)的化合物,其中W,Ar 1,Ar 2和Ar 3如下定义; 和这些化合物的药学上可接受的盐。 这些化合物是物质P拮抗剂,可用于治疗胃肠道疾病,炎性疾病,中枢神经系统疾病和疼痛。
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公开(公告)号:US5837711A
公开(公告)日:1998-11-17
申请号:US428240
申请日:1995-04-28
IPC分类号: C07D453/02 , A61K31/44
CPC分类号: C07D453/02
摘要: Certain novel substituted quinuclidine compounds having the ability to antagonize substance P and having the following formula: ##STR1## wherein Ar.sup.1 and Ar.sup.2 are each, independently, thienyl, phenyl, fluorophenyl, chlorophenyl or bromophenyl; X is --CONR.sup.3 R.sup.4, --CO.sub.2 R.sup.3, --CH.sub.2 OR.sup.3, --CH.sub.2 NR.sup.3 R.sup.4 or --CONR.sup.3 OR.sup.4 ; R.sup.1, R.sup.3 and R.sup.4 are each, independently, hydrogen or alkyl having 1 to 4 carbon atoms; R.sup.2 is alkyl having 1 to 4 carbon atoms; Y is alkylsulfonyl having 1 to 4 carbon atoms, N-alkyl-N-alkanoylamino (which may be substituted by halogen in the alkanoyl moiety) having 1 to 4 carbon atoms in the alkyl and the alkanoyl moieties, N-alkyl-N-alkylsulfonylamino (which may be substituted by halogen in the alkylsulfonyl moiety) having 1 to 4 carbon atoms in the alkyl and the alkyl sulfonyl moieties, alkenyl having 2 to 4 carbon atoms, alkynyl having 2 to 4 carbon atoms, halosubstituted alkyl having 1 to 4 carbon atoms, alkylamino having 1 to 4 carbon atoms, alkanoylamino (which may be substituted by halogen) having 1 to 4 carbon atoms or alkylsulfonylamino (which may be substituted by halogen) having 1 to 4 carbon atoms. These compounds are useful in the treatment gastrointestinal or central nervous system disorders and the alleviation of inflammatory diseases, asthma, pain and migraine in mammals and as the active ingredient in pharmaceutical compositions for treating such conditions.
摘要翻译: PCT No.PCT / US93 / 09169 Sec。 371日期:1995年4月28日 102(e)日期1995年4月28日PCT 1993年9月30日PCT公布。 出版物WO94 / 10170 日期:1994年5月11日具有拮抗物质P并具有下式的新颖取代的奎宁环化合物:其中Ar 1和Ar 2各自独立地为噻吩基,苯基,氟苯基,氯苯基或溴苯基; X是-CONR 3 R 4,-CO 2 R 3,-CH 2 OR 3,-CH 2 NR 3 R 4或-CONR 3 OR 4; R 1,R 3和R 4各自独立地为氢或具有1至4个碳原子的烷基; R2是具有1至4个碳原子的烷基; Y是具有1至4个碳原子的烷基磺酰基,在烷基和烷酰基部分中具有1至4个碳原子的N-烷基-N-烷酰基氨基(其可被烷酰基部分中被卤素取代)为N-烷基-N-烷基磺酰基氨基 (其可以被烷基磺酰基部分中的卤素取代)在烷基和烷基磺酰基部分中具有1至4个碳原子,具有2至4个碳原子的烯基,具有2至4个碳原子的炔基,具有1至4个碳原子的卤代烷基 原子,具有1至4个碳原子的烷基氨基,具有1至4个碳原子的烷酰基氨基(其可以被卤素取代)或具有1至4个碳原子的烷基磺酰基氨基(可被卤素取代)。 这些化合物可用于治疗哺乳动物的胃肠道或中枢神经系统疾病和减轻炎性疾病,哮喘,疼痛和偏头痛,并用作用于治疗这些病症的药物组合物中的活性成分。
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公开(公告)号:US5086062A
公开(公告)日:1992-02-04
申请号:US529971
申请日:1990-05-29
申请人: Kazuo Ando , Nobuko Asai , Fumitaka Ito , Takashi Mano , Masami Nakane , Kunio Satake , Kaoru Shimada
发明人: Kazuo Ando , Nobuko Asai , Fumitaka Ito , Takashi Mano , Masami Nakane , Kunio Satake , Kaoru Shimada
IPC分类号: C12N9/99 , A61K31/42 , A61K31/423 , A61K31/424 , A61K31/435 , A61K31/445 , A61P29/00 , A61P37/08 , A61P43/00 , C07D263/58 , C07D407/02 , C07D409/12 , C07D413/12 , C07D493/08
CPC分类号: C07D263/58 , C07D413/12 , C07D493/08 , Y02P20/55
摘要: This invention relates to certain benzoxazolinones which inhibit lipoxygenase and/or cyclooxygenase enzymes. Such compounds are useful in inhibiting such enzymes, per se, and are useful in treating allergic and inflammatory conditions in a mammal. This invention also relates to methods of inhibiting lipoxygenase and/or cyclooxygenase in a mammal with such benzoxazolinones; methods of treating an allergic condition in a mammal with such compounds; methods of treating an inflammatory condition in a mammal with such compounds; and pharmaceutical compositions comprising the benzoxazolinones hereof.
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公开(公告)号:US5721255A
公开(公告)日:1998-02-24
申请号:US387765
申请日:1995-02-15
申请人: Harry R. Howard , Masami Nakane , Masaya Ikunaka , Kunio Satake , Terry J. Rosen , John A. Lowe, III , Brian T. O'Neill , Fumitaka Ito
发明人: Harry R. Howard , Masami Nakane , Masaya Ikunaka , Kunio Satake , Terry J. Rosen , John A. Lowe, III , Brian T. O'Neill , Fumitaka Ito
IPC分类号: C07D333/36 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/41 , A61K31/425 , A61K31/435 , A61K31/4427 , A61K31/445 , A61K31/451 , A61P9/08 , A61P11/16 , A61P25/02 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P29/00 , A61P37/00 , A61P37/08 , C07D207/14 , C07D209/52 , C07D211/56 , C07D401/12 , C07D417/12 , C07D453/02 , C07D487/08 , A61K31/47
CPC分类号: C07D401/12 , C07D211/56 , C07D417/12 , C07D453/02 , C07D487/08
摘要: The present invention relates to novel substituted benzylamino nitrogen containing non-aromatic heterocycles and, specifically, to compounds of the formula ##STR1## wherein W, R.sup.1, R.sup.2, R.sup.3 and A are as defined in the specification, and to intermediates used in the synthesis of such compounds. The novel compounds of formula I are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.
摘要翻译: PCT No.PCT / US93 / 04063。 371日期1995年2月15日 102(e)日期1995年2月15日PCT提交1993年5月5日PCT公布。 公开号WO94 / 04496 1994年3月3日本发明涉及新的取代的苄基氨基氮的非芳族杂环,具体地说,涉及下式化合物其中W,R1,R2,R3和A如说明书中所定义, 用于合成这些化合物的中间体。 式I的新型化合物可用于治疗炎性和中枢神经系统疾病以及其它疾病。
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公开(公告)号:US5256789A
公开(公告)日:1993-10-26
申请号:US835934
申请日:1992-02-18
IPC分类号: A61K31/16 , A61K31/17 , A61K31/47 , A61P9/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C259/06 , C07C275/64 , C07C311/06 , C07C323/41 , C07C323/60 , C07D213/64 , C07D213/69 , C07D215/12 , C07D215/14 , C07D215/18 , C07D215/20 , C07D277/34 , C07D309/12 , C07D311/58 , C07D311/60 , C07D317/64 , C07D401/06 , C07D409/06 , C07D25/14
CPC分类号: C07D213/64 , C07C259/06 , C07C275/64 , C07D213/69 , C07D215/12 , C07D215/14 , C07D215/18 , C07D215/20 , C07D277/34 , C07D309/12 , C07D311/58 , C07D311/60 , C07D317/64 , C07D401/06 , C07D409/06 , C07C2102/08
摘要: Compounds having the structure ##STR1## wherein X is nitrogen, oxygen, sulfur or a bond and Z is oxygen or sulfur have been synthesized. These compounds are lipoxygenase inhibitors and are useful as the active agent in pharmaceutical compositions for treating inflammatory conditions in humans and other mammals for which lipoxygenase activity has been implicated.
摘要翻译: 已经合成了具有结构
的化合物,其中X是氮,氧,硫或键,Z是氧或硫。 这些化合物是脂氧合酶抑制剂,并且可用作用于治疗已经涉及脂氧合酶活性的人和其它哺乳动物的炎性病症的药物组合物中的活性剂。 -
公开(公告)号:US5104874A
公开(公告)日:1992-04-14
申请号:US627149
申请日:1990-12-13
IPC分类号: A61K31/135 , A61K31/16 , A61K31/18 , A61K31/19 , A61K31/215 , A61K31/33 , A61K31/495 , A61K31/496 , A61P29/00 , A61P43/00 , C07C225/28 , C07C229/14 , C07C229/18 , C07C229/32 , C07C229/42 , C07C229/48 , C07C229/56 , C07C231/12 , C07C235/80 , C07C237/20 , C07C237/30 , C07C311/39 , C07D213/74 , C07D263/56 , C07D295/10 , C07D307/14 , C07D307/52
CPC分类号: C07D213/74 , C07C225/28 , C07C229/14 , C07C229/42 , C07C229/48 , C07C229/56 , C07C235/80 , C07C237/20 , C07C311/39 , C07D307/14 , C07D307/52 , C07C2101/14 , C07C2101/16
摘要: A series of 2-amino-5,6-dimethyl-1,4-benzoquinone derivatives, inhibitors of cyclooxygenase and lipoxygenase and useful as antiallergic and antiinflammatory agents.
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公开(公告)号:US09193286B2
公开(公告)日:2015-11-24
申请号:US13486307
申请日:2012-06-01
申请人: Sakae Okuyama , Masami Nakane
发明人: Sakae Okuyama , Masami Nakane
CPC分类号: B60N2/5825 , A47C7/18 , A47C31/02 , B60N2/5816 , B60N2/5841
摘要: A vehicle seat including: a seat component including, a cushion material forming an outer shape of the vehicle seat, a plurality of groove parts formed to the cushion material and intersecting each other, a corner part formed by intersection of the plurality of groove parts, and a skin material covering the cushion material, wherein the skin material covers the cushion material while a portion of the skin material is engaged inside the plurality of groove parts in a pulled state, wherein the cushion material includes a protruding portion protruding from an external portion of the corner part, and wherein the protruding portion covers the external portion of the corner part and shrinks toward the external portion of the corner part by a pressing force of the skin material engaged inside the plurality of groove parts in the pulled state.
摘要翻译: 一种车辆座椅,包括:座椅部件,包括形成所述车辆座椅的外部形状的缓冲材料,形成在所述缓冲材料上并相互交叉的多个槽部,通过所述多个槽部的交叉形成的角部, 以及覆盖所述衬垫材料的表皮材料,其中所述表皮材料覆盖所述衬垫材料,同时所述表皮材料的一部分在拉伸状态下接合在所述多个凹槽部分内,其中所述衬垫材料包括从外部突出的突出部分 并且其中所述突出部分覆盖所述拐角部分的外部,并且在所述拉伸状态下通过所述多个凹槽部分内的所述表皮材料的压力而朝所述角部的外部收缩。
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