公开(公告)号：US4820689A

公开(公告)日：1989-04-11

申请号：US898900

申请日：1986-08-22

申请人： Masanori Ikuzawa ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Noriyuki Toyoda ,  Takao Furusho ,  Takayoshi Fujii ,  Chikao Yoshikumi

发明人： Masanori Ikuzawa ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Noriyuki Toyoda ,  Takao Furusho ,  Takayoshi Fujii ,  Chikao Yoshikumi

IPC分类号： A61K38/00 ,  C07K14/375 ,  A61K37/02 ,  A61K35/70

CPC分类号： C07K14/375 ,  A61K38/00 ,  Y10S435/911

摘要： Disclosed herein is a pharmaceutical composition having antirheumatic activity, antithrombotic activity, analgetic activity, antipyretic activity, anti-hyperlipemic activity and anti-inflammatory activity and activities of reducing the level of blood sugar, raising the coronary blood flow, improving the capability of deformation of erythrocytes, reducing the blood pressure, ameliorating proteinuria and proteinemia and regulating production or metabolism of prostaglandins in a mammal in dosage unit form, which comprises a dosage effective to produce said activities of a glycoprotein having a molecular weight of 5000 to 300000 as determined by ultracentrifugal method and about 18 to 38% by weight of proteins, produced by culturing a basidiomycetous fungal species belonging to the genus Coriolus, extracting the thus proliferated mycelia or fruit bodies with hot water or aqueous alkali solution and removing low molecular weight substances having a molecular weight of less than 5000 from the extract.

摘要翻译： 本文公开了具有抗风湿活性，抗血栓活性，止痛活性，解热活性，抗高血脂活性和抗炎活性以及降低血糖水平的活性，提高冠状动脉血流量，提高变形能力的药物组合物 红细胞，降低血压，改善蛋白尿和蛋白血症，并以剂量​​单位形式调节哺乳动物中前列腺素的产生或代谢，其包括有效产生分子量为5000至300000的糖蛋白的活性的剂量，其通过超速离心 方法和约18〜38重量％的蛋白质，通过培养属于科氏菌属的嗜碱性真菌属真菌属物种，用热水或碱性水溶液提取如此增殖的菌丝体或果实体并除去分子量低的分子量物质 从不到5000 e提取。

公开(公告)号：US5008243A

公开(公告)日：1991-04-16

申请号：US285664

申请日：1988-12-16

申请人： Masanori Ikuzawa ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Noriyuki Toyoda ,  Takao Furusho ,  Takayoshi Fujii ,  Chikao Yoshikumi

发明人： Masanori Ikuzawa ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Noriyuki Toyoda ,  Takao Furusho ,  Takayoshi Fujii ,  Chikao Yoshikumi

IPC分类号： A61K38/00 ,  C07K14/375

CPC分类号： C07K14/375 ,  A61K38/00 ,  Y10S435/911

摘要： Disclosed herein is a pharmaceutical composition having antirheumatic activity, antithrombotic activity, analgetic activity, antipyretics activity, anti-hyperlipemic activity and anti-inflammatory activity and activities of reducing the level of blood sugar, raising the coronary blood flow, improving the capability of deformation of erythrocytes, reducing the blood pressure, ameliorating proteinuria and proteinemia and regulating production or metabolism of prostaglandins in a mammal in dosage unit form, which comprises a dosage effective to produce said activities of a glycoprotein having a molecular weight of 5000 to 300,000 as determined by ultracentrifugal method and about 18 to 38% by weight of proteins, produced by culturing a basidiomycetous fungal species belonging to the genus Coriolus, extracting the thus proliferated mycelia or fruit bodies with hot water or aqueous alkali solution and removing low molecular weight substances having a molecular weight of less than 5000 from the extract.

公开(公告)号：US4673669A

公开(公告)日：1987-06-16

申请号：US786851

申请日：1985-10-11

申请人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

发明人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

IPC分类号： C07H15/203 ,  A61K31/70

CPC分类号： C07H15/203

摘要： Disclosed is a pharmaceutical composition containing an aminobenzoic acid derivative as an active ingredient represented by the following general formula: ##STR1## wherein .sup.1 R donotes one member selected from the group consisting of the residual groups formed by removing OH at 1(alpha) or 1(beta) position from arabinose, glucose, galactose and mannose, or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明公开了含有氨基苯甲酸衍生物作为活性成分的药物组合物，其由以下通式表示：其中，R 1表示选自由1（α）或1（α） β）位置，或其药学上可接受的盐。

公开(公告)号：US4657895A

公开(公告)日：1987-04-14

申请号：US772477

申请日：1985-09-04

申请人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

发明人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

IPC分类号： C07H15/203 ,  A61K31/70

CPC分类号： C07H15/203

摘要： Disclosed is a pharmaceutical composition containing p-aminobenzoic acid-N-L-rhamonoside or a pharmaceutically acceptable salt thereof as an active ingredient.

摘要翻译： 公开了含有对氨基苯甲酸-N-L-鼠李糖苷或其药学上可接受的盐作为活性成分的药物组合物。

公开(公告)号：US4569842A

公开(公告)日：1986-02-11

申请号：US352858

申请日：1982-02-26

申请人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

发明人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

IPC分类号： C07H15/203 ,  A61K31/70

CPC分类号： C07H15/203

摘要： Disclosed is a pharmaceutical composition containing an aminobenzoic acid derivative as an active ingredient represented by the following general formula: ##STR1## wherein .sup.1 R denotes one member selected from the group consisting of the residual groups formed by removing OH at 1(alpha) or 1(beta) position from arabinose, glucose, galactose and mannose, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US4801581A

公开(公告)日：1989-01-31

申请号：US714354

申请日：1985-03-22

申请人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohara ,  Takao Ando

发明人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohara ,  Takao Ando

IPC分类号： C07H15/203 ,  A61K31/70

CPC分类号： C07H15/203

摘要： Disclosed is a pharmaceutical composition containing p-aminobenzoic acid-N-D-xyloside or a pharmaceutically a acceptable salt thereof as an active ingredient.

摘要翻译： 公开了含有对氨基苯甲酸-N-D-木糖苷或其药学上可接受的盐作为活性成分的药物组合物。

公开(公告)号：US4649133A

公开(公告)日：1987-03-10

申请号：US780211

申请日：1985-09-26

申请人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

发明人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

IPC分类号： C07H15/203 ,  A61K31/70

CPC分类号： C07H15/203

摘要： Disclosed is a method for the treatment of hyperglycemia, hyperlipemia, inflammatory diseases, pains due to the accentuation of central nerve, pyrexia due to the accentuation of central nerve or tumor, which comprises administering to a patient suffering therefrom a pharmaceutically effective amount of p-aminobenzoic acid-N-L-rhamnoside or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明公开了一种治疗高血糖症，高脂血症，炎症性疾病，由于中枢神经突出而引起的疼痛，由于中枢神经或肿瘤引起的发热，其包括向患有其的药物有效量的对 - 氨基苯甲酸-NL-鼠李糖苷或其药学上可接受的盐。

公开(公告)号：US4450156A

公开(公告)日：1984-05-22

申请号：US294502

申请日：1981-08-20

申请人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

发明人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

IPC分类号： C07H15/203 ,  A61K31/70

CPC分类号： C07H15/203

摘要： Disclosed is a pharmaceutical composition containing an aminobenzoic acid derivative as an active ingredient represented by the following general formula: ##STR1## wherein .sup.1 R denotes one member selected from the group consisting of the residual groups formed by removing OH at 1(alpha) or 1(beta) position from arabinose, xylose, glucose, galactose, rhamnose and mannose, and .sup.2 R denotes hydrogen or methyl group, or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明公开了一种含有氨基苯甲酸衍生物作为活性成分的药物组合物，由以下通式表示：其中1R表示选自由1（α）或1（α）除去OH而形成的残基， β-葡萄糖，半乳糖，鼠李糖和甘露糖，2R表示氢或甲基，或其药学上可接受的盐。

公开(公告)号：US4372948A

公开(公告)日：1983-02-08

申请号：US247521

申请日：1981-03-25

申请人： Chikao Yoshikumi ,  Fumio Hirose ,  Yoshio Ohmura ,  Takayoshi Fujii ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takao Ando ,  Minoru Ohhara

发明人： Chikao Yoshikumi ,  Fumio Hirose ,  Yoshio Ohmura ,  Takayoshi Fujii ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takao Ando ,  Minoru Ohhara

IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61P3/06 ,  A61P3/08 ,  A61P9/10 ,  A61P9/12 ,  A61P25/00 ,  A61P25/04 ,  A61P29/00 ,  A61P35/00 ,  C07H15/203 ,  C08B37/00

CPC分类号： C07H15/203

摘要： The novel derivatives of saccharide obtained by bringing a saccharide into reaction with an ester of aminobenzoic acid, an aminobenzoic acid amide, an aminophenylacetic acid or an ester thereof have various physiological activities.

摘要翻译： 通过使糖与氨基苯甲酸，氨基苯甲酸酰胺，氨基苯乙酸或其酯的酯反应而获得的糖的新型衍生物具有各种生理活性。

公开(公告)号：US4315921A

公开(公告)日：1982-02-16

申请号：US102224

申请日：1979-12-10

申请人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

发明人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

IPC分类号： C07H15/203 ,  A61K31/70

CPC分类号： C07H15/203

摘要： Disclosed is a pharmaceutical composition containing p-aminobenzoic acid-N-D-xyloside or a pharmaceutically acceptable salt thereof as an active ingredient.

摘要翻译： 公开了含有对氨基苯甲酸-N-D-木糖苷或其药学上可接受的盐作为活性成分的药物组合物。