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11 条记录 (耗时 0.027 秒)

    Pharmaceutical composition containing a glycoprotein
    1.
    发明授权
    Pharmaceutical composition containing a glycoprotein 失效
    含有糖蛋白的药物组合物

    公开(公告)号：US4820689A

    公开(公告)日：1989-04-11

    申请号：US898900

    申请日：1986-08-22

    申请人： Masanori Ikuzawa ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Noriyuki Toyoda ,  Takao Furusho ,  Takayoshi Fujii ,  Chikao Yoshikumi

    发明人： Masanori Ikuzawa ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Noriyuki Toyoda ,  Takao Furusho ,  Takayoshi Fujii ,  Chikao Yoshikumi

    IPC分类号： A61K38/00 ,  C07K14/375 ,  A61K37/02 ,  A61K35/70

    CPC分类号： C07K14/375 ,  A61K38/00 ,  Y10S435/911

    摘要： Disclosed herein is a pharmaceutical composition having antirheumatic activity, antithrombotic activity, analgetic activity, antipyretic activity, anti-hyperlipemic activity and anti-inflammatory activity and activities of reducing the level of blood sugar, raising the coronary blood flow, improving the capability of deformation of erythrocytes, reducing the blood pressure, ameliorating proteinuria and proteinemia and regulating production or metabolism of prostaglandins in a mammal in dosage unit form, which comprises a dosage effective to produce said activities of a glycoprotein having a molecular weight of 5000 to 300000 as determined by ultracentrifugal method and about 18 to 38% by weight of proteins, produced by culturing a basidiomycetous fungal species belonging to the genus Coriolus, extracting the thus proliferated mycelia or fruit bodies with hot water or aqueous alkali solution and removing low molecular weight substances having a molecular weight of less than 5000 from the extract.

    摘要翻译： 本文公开了具有抗风湿活性，抗血栓活性，止痛活性，解热活性，抗高血脂活性和抗炎活性以及降低血糖水平的活性，提高冠状动脉血流量，提高变形能力的药物组合物 红细胞，降低血压，改善蛋白尿和蛋白血症，并以剂量​​单位形式调节哺乳动物中前列腺素的产生或代谢，其包括有效产生分子量为5000至300000的糖蛋白的活性的剂量，其通过超速离心 方法和约18〜38重量％的蛋白质，通过培养属于科氏菌属的嗜碱性真菌属真菌属物种，用热水或碱性水溶液提取如此增殖的菌丝体或果实体并除去分子量低的分子量物质 从不到5000 e提取。

    Method for examining cells by electrophoresis
    10.
    发明授权
    Method for examining cells by electrophoresis 失效
    电泳检测细胞的方法

    公开(公告)号：US4632743A

    公开(公告)日：1986-12-30

    申请号：US568951

    申请日：1984-04-25

    申请人： Chikao Yoshikumi ,  Kenichi Matsunaga ,  Haruhisa Hayashi ,  Yoshiharu Oguchi

    发明人： Chikao Yoshikumi ,  Kenichi Matsunaga ,  Haruhisa Hayashi ,  Yoshiharu Oguchi

    IPC分类号： G01N27/26 ,  G01N27/447 ,  G01N33/483

    CPC分类号： G01N27/447

    摘要： Cells, particularly lymphocytes in peripheral blood or lymphatic tissues such as thymus, spleen and lymph node, are examined by measuring an electrophoretic property, such as a fraction of the number of the cells having an electrophoretic mobility within a predetermined range to the total number of the cells to be examined, with the aid of an automatic electrophoretic apparatus which is operated in a medium of the physiological conditions and by reversing the electric field, and comparing the obtained pattern of the electrophoretic property of the cells to be examined with the pattern of the electrophoretic property of normal host-cells, in order to diagnose cancer.

    摘要翻译： 通过测量电泳性质来检查细胞，特别是外周血或淋巴组织如胸腺，脾脏和淋巴结中的淋巴细胞，例如电泳迁移率的数目的一部分在预定范围内的总数 借助于在生理条件培养基中操作并通过反转电场的自动电泳装置，并将获得的待检细胞的电泳性质图案与所检查的细胞的图案进行比较 正常宿主细胞的电泳性质，以诊断癌症。