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公开(公告)号:US20060252800A1
公开(公告)日:2006-11-09
申请号:US10555539
申请日:2004-04-30
IPC分类号: A61K31/4439 , C07D417/14
CPC分类号: C07D417/14
摘要: The present invention is to provide a new anti-leishmania agent with fewer side effects, having a high cell proliferation-inhibiting effect to leishamia protozoa, and also easy to manufacture at a low cost. A compound wherein a heterocycle with a conjugated system and a nitrogen atom and a heterocycle with a nitrogen atom and a sulfur atom are bound by a carbon chain with an ethylene group, that is a compound wherein a specific 5- to 8-membered heterocyclic ring and a specific 5- to 8-membered heterocycle having a conjugated system are bound via a vinylene group, more particularly a specific rhodacyanine dye compound is used as an active ingredient of the anti-leishmania agent.
摘要翻译: 本发明提供一种具有较少副作用的新型利什曼原虫药,其具有对嗜酸性原虫的高细胞增殖抑制作用,并且也易于以低成本制造。 其中具有共轭体系和氮原子的杂环和具有氮原子和硫原子的杂环的亚乙基与碳原子键合的化合物,其中特定的5-至8-元杂环 并且具有共轭体系的具体的5-至8-元杂环通过亚乙烯基结合,更具体地,使用特定的罗丹参素染料化合物作为抗利什曼原虫剂的活性成分。
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公开(公告)号:US20080254136A1
公开(公告)日:2008-10-16
申请号:US11632959
申请日:2005-07-20
IPC分类号: A61K35/12 , A61K31/122 , A61P33/02 , A61K36/30
CPC分类号: A61K36/30 , A61K31/122 , A61K36/232 , Y02A50/409 , A61K2300/00
摘要: The present invention provides an antiprotozoal agent, which is particularly preferred as an antileishmanial agent. Specifically, the present invention is directed to an antiprotozoal agent comprising, as an active ingredient, a compound of Formula (I): wherein R is —H or acyl, a salt thereof, or solvate thereof.
摘要翻译: 本发明提供了一种抗原虫药,特别优选作为防腐剂。 具体地,本发明涉及一种抗原虫剂,其包含作为活性成分的式(I)的化合物:其中R是-H或酰基,其盐或其溶剂合物。
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