公开(公告)号：US20150025232A1

公开(公告)日：2015-01-22

申请号：US14241580

申请日：2012-08-24

申请人： Masayuki Nashimoto ,  Masuhiro Takahashi ,  Miwako Narita ,  Tetsuo Yoshida ,  Tatsuya Miyazawa

发明人： Masayuki Nashimoto ,  Masuhiro Takahashi ,  Miwako Narita ,  Tetsuo Yoshida ,  Tatsuya Miyazawa

IPC分类号： C12N15/113

CPC分类号： C12N15/113 ,  A61K31/7105 ,  C12N2310/12

摘要： There is provided a heptamer-type small guide nucleic acid that comprises any of the 7-base sequences of SEQ ID NOS: 1 to 15, and induces apoptosis of human leukemia cells. A leukemia therapeutic agent containing the heptamer-type small guide nucleic acid as an active ingredient is also provided. The novel heptamer-type sg nucleic acid can induce apoptosis of human leukemia cells.

摘要翻译： 提供了包含SEQ ID NO：1至15的任何7-碱基序列的七聚体型小导向核酸，并诱导人白血病细胞的凋亡。 还提供含有七聚体型小引导核酸作为有效成分的白血病治疗剂。 新型七聚体型sg核酸可诱导人白血病细胞凋亡。

公开(公告)号：US09617538B2

公开(公告)日：2017-04-11

申请号：US14241580

申请日：2012-08-24

申请人： Masayuki Nashimoto ,  Masuhiro Takahashi ,  Miwako Narita ,  Tetsuo Yoshida ,  Tatsuya Miyazawa

发明人： Masayuki Nashimoto ,  Masuhiro Takahashi ,  Miwako Narita ,  Tetsuo Yoshida ,  Tatsuya Miyazawa

IPC分类号： C07H21/02 ,  C12N15/113 ,  A61K31/7105

CPC分类号： C12N15/113 ,  A61K31/7105 ,  C12N2310/12

摘要： There is provided a heptamer-type small guide nucleic acid that comprises any of the 7-base sequences of SEQ ID NOS: 1 to 15, and induces apoptosis of human leukemia cells. A leukemia therapeutic agent containing the heptamer-type small guide nucleic acid as an active ingredient is also provided. The novel heptamer-type sg nucleic acid can induce apoptosis of human leukemia cells.

公开(公告)号：US20050118687A1

公开(公告)日：2005-06-02

申请号：US10489821

申请日：2002-03-20

申请人： Masayuki Nashimoto

发明人： Masayuki Nashimoto

IPC分类号： C12N15/09 ,  C07K14/00 ,  C12N9/22 ,  C12N15/10 ,  C12N15/11 ,  C12P19/34

CPC分类号： C12N15/1062

摘要： As a molecular material for synthesizing a protein-encoding polynucleotide via reverse translation from the protein, a reverse translation-mediating oligonucleotide having the following properties (a) to (d) is provided: (a) containing a nucleotide sequence “nnn” encoding an amino acid residue “Xaa”; (b) the nucleotide sequence “nnn” being separable; (c) containing a nucleotide sequence binding to the amino acid residue “Xaa”; and (d) not containing any nucleotide sequence binding to an amino acid residue other than the amino acid residue “Xaa”. Also, a method of synthesizing a polynucleotide encoding the amino acid sequence of the primitive protein via a reverse translation reaction with the above oligonucleotide is provided.

摘要翻译： 作为通过从蛋白质反向翻译合成编码蛋白质的多核苷酸的分子材料，提供了具有以下特性（a）〜（d）的反向翻译介导的寡核苷酸：（a）含有编码 氨基酸残基“Xaa”; （b）核苷酸序列“nnn”是可分离的; （c）含有与氨基酸残基“Xaa”结合的核苷酸序列; 和（d）不含有与氨基酸残基“Xaa”以外的氨基酸残基结合的核苷酸序列。 此外，提供了通过与上述寡核苷酸的反转译反应合成编码原始蛋白质的氨基酸序列的多核苷酸的方法。