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    SELF-ACTUATING ARTICLES
    8.
    发明申请
    SELF-ACTUATING ARTICLES 有权

    公开(公告)号：US20220257855A1

    公开(公告)日：2022-08-18

    申请号：US16614177

    申请日：2018-05-17

    申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    发明人： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  Robert S. Langer

    IPC分类号： A61M5/158

    摘要： Self-actuating articles including, for example, self-actuating needles and/or self-actuating biopsy punches, are generally provided. Advantageously, the self-actuating articles described herein may be useful as a general platform for delivery of a wide variety of pharmaceutical drugs that are typically delivered via injection directly into tissue due to degradation in the GI tract. The self-actuating articles described herein may also be used to deliver sensors and/or take biopsies without the need for an endoscopy. In some embodiments, the article comprises a spring (e.g., a coil spring, a beam, a material having particular mechanical recovery characteristics). Those of ordinary skill in the art would understand that the term spring is not intended to be limited to coil springs, but generally encompass any reversibly compressive material and/or component which, after releasing an applied compressive force on the material/component, the material/component substantially returns to an uncompressed length of the material/component (e.g., the within 95% of the length of the material/component prior to compression).

    ARTICLES AND METHODS FOR ADMINISTRATION OF THERAPEUTIC AGENTS
    9.
    发明申请
    ARTICLES AND METHODS FOR ADMINISTRATION OF THERAPEUTIC AGENTS 有权

    公开(公告)号：US20220202721A1

    公开(公告)日：2022-06-30

    申请号：US17569881

    申请日：2022-01-06

    申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    发明人： Carlo Giovanni Traverso ,  Joshua Korzenik ,  Robert S. Langer ,  Christoph Winfried Johannes Steiger

    IPC分类号： A61K9/20 ,  A61K9/28 ,  A61K9/48

    摘要： Articles and methods for delivering a therapeutic agent to a subject are described. These articles and methods may be useful, in some cases, for the delivery of therapeutic agents to the colon of a subject. In some embodiments, an article is configured to release a secretion inducing agent e.g., to stimulate the release of intestinal fluids. The article, in some embodiments, comprises a therapeutic agent such that the stimulated release of intestinal fluid increases the amount of therapeutic agent available for absorption by the colon. For example, in some embodiments, the articles and methods described herein advantageously promote increased absorption of therapeutic agents in subjects as compared to traditionally administered therapeutic agents without additional components such as a secretion inducing agent. In some embodiments, articles and methods described herein may increase the motility of the colon of a subject. The increase in contractions and movement of fluidic in the colon caused by increase motility may advantageously facilitate the dissolution or absorption of the therapeutic agent.

    SYSTEMS FOR ELECTRICAL STIMULATION
    10.
    发明申请
    SYSTEMS FOR ELECTRICAL STIMULATION 有权

    公开(公告)号：US20220193399A1

    公开(公告)日：2022-06-23

    申请号：US17512156

    申请日：2021-10-27

    申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    发明人： Robert S. Langer ,  Carlo Giovanni Traverso ,  Alex G. Abramson ,  David Dellal

    IPC分类号： A61N1/05 ,  A61L31/02 ,  A61N1/36 ,  A61N1/372

    摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one 5 or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In certain embodiments, the self-righting article a tissuel0 interfacing components. In some embodiments, each tissue-interfacing component may comprise an electrically-conductive portion configured for electrical communication with tissue and an insulative portion configured to not be in electrical communication with tissue.