公开(公告)号：US20190083495A1

公开(公告)日：2019-03-21

申请号：US16081654

申请日：2017-04-04

Applicant: Massachusetts Institute of Technology

Inventor： Joshua C. Doloff ,  Shady Farah ,  Omid Veiseh ,  Arturo J. Vegas ,  Robert S. Langer ,  Daniel G. Anderson

IPC: A61K31/519 ,  A61K31/4709 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/416 ,  A61K31/444 ,  A61K31/496 ,  A61K31/404 ,  A61K31/553 ,  A61K31/551 ,  A61K31/5025

Abstract: Described herein are methods of preventing or reducing fibrosis comprising administering CSF1R inhibitors, coating formulations comprising CSF1R inhibitors, coatings comprising CSF1R inhibitors for implantable medical devices, CSF1R inhibitor coated implantable medical devices, as well as corresponding embodiments comprising additional agents.

公开(公告)号：US10851069B2

公开(公告)日：2020-12-01

申请号：US16091330

申请日：2017-04-04

Applicant: Massachusetts Institute of Technology

Inventor： Shady Farah ,  Joshua C. Doloff ,  Robert S. Langer ,  Daniel G. Anderson

IPC: C07D239/49 ,  A61K31/505 ,  A61P29/00 ,  A61K31/404 ,  A61K31/416 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/553 ,  A61K9/00

Abstract: The present invention provides, in certain embodiments, compositions comprising a uniform population of free, single crystals of a hydrophobic compound. Methods of administering, and processes for preparing, compositions comprising a uniform population of free, single crystals of a hydrophobic compound are also provided.

公开(公告)号：US20190210976A1

公开(公告)日：2019-07-11

申请号：US16091330

申请日：2017-04-04

Applicant: Massachusetts Institute of Technology

Inventor： Shady Farah ,  Joshua C. Doloff ,  Robert S. Langer ,  Daniel G. Anderson

IPC: C07D239/49 ,  A61P29/00 ,  A61K9/00

CPC classification number: C07D239/49 ,  A61K9/0024 ,  A61K31/404 ,  A61K31/416 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/553 ,  A61P29/00 ,  C07B2200/13

Abstract: The present invention provides, in certain embodiments, compositions comprising a uniform population of free, single crystals of a hydrophobic compound. Methods of administering, and processes for preparing, compositions comprising a uniform population of free, single crystals of a hydrophobic compound are also provided.