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公开(公告)号:US20080015220A1
公开(公告)日:2008-01-17
申请号:US11888526
申请日:2007-08-01
申请人: Mathai Mammen , Sarah Dunham , Adam Hughes , Tae Weon Lee , Craig Husfeld , Eric Stangeland , Yan Chen
发明人: Mathai Mammen , Sarah Dunham , Adam Hughes , Tae Weon Lee , Craig Husfeld , Eric Stangeland , Yan Chen
CPC分类号: C07D211/46 , A61K31/445 , A61K31/452 , C07D211/48 , C07D211/58 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D453/02 , C07D471/08 , G01N33/9433
摘要: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
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公开(公告)号:US07879879B2
公开(公告)日:2011-02-01
申请号:US11448317
申请日:2006-06-07
申请人: Mathai Mammen , Sarah Dunham , Adam Hughes , Craig Husfeld , Eric Stangeland , Yan Chen
发明人: Mathai Mammen , Sarah Dunham , Adam Hughes , Craig Husfeld , Eric Stangeland , Yan Chen
IPC分类号: A61K31/445 , C07D211/54 , C07D211/56
CPC分类号: C07D211/46 , A61K31/445 , A61K31/452 , C07D211/48 , C07D211/58 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D453/02 , C07D471/08 , G01N33/9433
摘要: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
摘要翻译: 本发明提供式I的联苯衍生物:其中R1,R2,R3,R4,R5,R6,R7,W,a,b和c如说明书中所定义,或其药学上可接受的盐或溶剂合物或立体异构体。 本发明的联苯衍生物具有二肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性,因此,这种联苯衍生物可用于治疗肺部疾病,如慢性阻塞性肺疾病和哮喘。
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公开(公告)号:US20070276003A1
公开(公告)日:2007-11-29
申请号:US11879004
申请日:2007-07-13
申请人: Mathai Mammen , Sarah Dunham , Adam Hughes , Tae Lee , Craig Husfeld , Eric Stangeland , Yan Chen
发明人: Mathai Mammen , Sarah Dunham , Adam Hughes , Tae Lee , Craig Husfeld , Eric Stangeland , Yan Chen
IPC分类号: A61K31/445
CPC分类号: C07D211/46 , A61K31/445 , A61K31/452 , C07D211/48 , C07D211/58 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D453/02 , C07D471/08 , G01N33/9433
摘要: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
摘要翻译: 本发明提供式I的联苯衍生物:其中R 1,R 2,R 3,R 4, R 5,R 6,R 7,W,a,b和c如说明书中所定义,或其药学上可接受的盐或 其溶剂合物或立体异构体。 本发明的联苯衍生物具有β2N2肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性,因此,这种联苯衍生物可用于治疗肺部疾病,如慢性阻塞性肺病和哮喘。
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公开(公告)号:US20070208176A1
公开(公告)日:2007-09-06
申请号:US11788343
申请日:2007-04-19
申请人: Mathai Mammen , Sarah Dunham , Adam Hughes , Tae Weon Lee , Craig Husfeld , Eric Stangeland , Yan Chen
发明人: Mathai Mammen , Sarah Dunham , Adam Hughes , Tae Weon Lee , Craig Husfeld , Eric Stangeland , Yan Chen
IPC分类号: C07D401/02
CPC分类号: C07D211/46 , A61K31/445 , A61K31/452 , C07D211/48 , C07D211/58 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D453/02 , C07D471/08 , G01N33/9433
摘要: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
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公开(公告)号:US07141671B2
公开(公告)日:2006-11-28
申请号:US10779157
申请日:2004-02-13
申请人: Mathai Mammen , Sarah Dunham , Adam Hughes , Tae Weon Lee , Craig Husfeld , Eric Stangeland , Yan Chen
发明人: Mathai Mammen , Sarah Dunham , Adam Hughes , Tae Weon Lee , Craig Husfeld , Eric Stangeland , Yan Chen
IPC分类号: C07D211/56 , C07D211/72 , A61K31/47 , A61K31/445
CPC分类号: C07D211/46 , A61K31/445 , A61K31/452 , C07D211/48 , C07D211/58 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D453/02 , C07D471/08 , G01N33/9433
摘要: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
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公开(公告)号:US20060223860A1
公开(公告)日:2006-10-05
申请号:US11448317
申请日:2006-06-07
申请人: Mathai Mammen , Sarah Dunham , Adam Hughes , Tae Lee , Craig Husfeld , Eric Stangeland , Yan Chen
发明人: Mathai Mammen , Sarah Dunham , Adam Hughes , Tae Lee , Craig Husfeld , Eric Stangeland , Yan Chen
IPC分类号: A61K31/445 , C07D211/54 , C07D211/56
CPC分类号: C07D211/46 , A61K31/445 , A61K31/452 , C07D211/48 , C07D211/58 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D453/02 , C07D471/08 , G01N33/9433
摘要: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
摘要翻译: 本发明提供式I的联苯衍生物:其中R 1,R 2,R 3,R 4, R 5,R 6,R 7,W,a,b和c如说明书中所定义,或其药学上可接受的盐或 其溶剂合物或立体异构体。 本发明的联苯衍生物具有β2N2肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性,因此,这种联苯衍生物可用于治疗肺部疾病,如慢性阻塞性肺病和哮喘。
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公开(公告)号:US20060281740A1
公开(公告)日:2006-12-14
申请号:US11451179
申请日:2006-06-12
申请人: Yu-Hua Ji , Mathai Mammen , Craig Husfeld , Li Li , YongQi Mu , Aaron Kushner , Eric Stangeland , Trevor Mischki , Adam Hughes , Sarah Dunham
发明人: Yu-Hua Ji , Mathai Mammen , Craig Husfeld , Li Li , YongQi Mu , Aaron Kushner , Eric Stangeland , Trevor Mischki , Adam Hughes , Sarah Dunham
IPC分类号: C07D417/02 , C07D413/02 , C07D401/02 , C07D403/02 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4545 , A61K31/454
CPC分类号: C07D211/46 , C07D405/12 , C07D409/12 , C07D487/08
摘要: The invention provides compounds of formula I: wherein a, b, c, m, s, t, W, Z, Ar, R1, R2, R3, R6, and R7 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译: 本发明提供式I化合物:其中a,b,c,m,s,t,w,Z,Ar,R 1,R 2, > 3 SUP>,R 6和R 7如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物,用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号:US20130150404A1
公开(公告)日:2013-06-13
申请号:US13545523
申请日:2012-07-10
申请人: Mathai Mammen , Sarah Dunham , Adam Hughes , Craig Husfeld , Eric Stangeland
发明人: Mathai Mammen , Sarah Dunham , Adam Hughes , Craig Husfeld , Eric Stangeland
IPC分类号: C07D401/12
CPC分类号: C07D211/46 , A61K31/445 , A61K31/452 , C07D211/48 , C07D211/58 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D453/02 , C07D471/08 , G01N33/9433
摘要: This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthmas.
摘要翻译: 本发明提供式I的联苯衍生物:其中R1,R2,R3,R4,R5,R6,R7,W,a,b和c如说明书中所定义,或其药学上可接受的盐或溶剂合物或立体异构体。 本发明的联苯衍生物具有β2肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性,因此,这种联苯衍生物可用于治疗肺部疾病,如慢性阻塞性肺病和哮喘。
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公开(公告)号:US08119796B2
公开(公告)日:2012-02-21
申请号:US13193874
申请日:2011-07-29
申请人: YuHua Ji , Mathai Mammen , Craig Husfeld , Li Li , YongQi Mu , Aaron Kushner , Eric Stangeland , Trevor Mischki , Adam Hughes , Sarah Dunham
发明人: YuHua Ji , Mathai Mammen , Craig Husfeld , Li Li , YongQi Mu , Aaron Kushner , Eric Stangeland , Trevor Mischki , Adam Hughes , Sarah Dunham
IPC分类号: C07D417/14 , C07D265/28 , C07D401/14 , A61K31/54 , A61K31/5377 , A61K31/496
CPC分类号: C07D211/46 , C07D405/12 , C07D409/12 , C07D487/08
摘要: The invention provides compounds of formula I: wherein a, b, c, m, s, t, W, Z, Ar, R1, R2, R3, R6, and R7 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译: 本发明提供式I化合物:其中a,b,c,m,s,t,w,Z,Ar,R 1,R 2,R 3,R 6和R 7如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物,用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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公开(公告)号:US08013152B2
公开(公告)日:2011-09-06
申请号:US12759887
申请日:2010-04-14
申请人: YuHua Ji , Mathai Mammen , Craig Husfeld , Li Li , YongQi Mu , Aaron Kushner , Eric Stangeland , Trevor Mischki , Adam Hughes , Sarah Dunham
发明人: YuHua Ji , Mathai Mammen , Craig Husfeld , Li Li , YongQi Mu , Aaron Kushner , Eric Stangeland , Trevor Mischki , Adam Hughes , Sarah Dunham
IPC分类号: C07D265/28 , C07D241/04 , A61K31/54 , A61K31/5375
CPC分类号: C07D211/46 , C07D405/12 , C07D409/12 , C07D487/08
摘要: The invention provides compounds of formula I: wherein a, b, c, m, s, t, W, Z, Ar, R1, R2, R3, R6, and R7 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
摘要翻译: 本发明提供式I化合物:其中a,b,c,m,s,t,w,Z,Ar,R 1,R 2,R 3,R 6和R 7如说明书中所定义。 式I化合物是毒蕈碱受体拮抗剂。 本发明还提供含有这些化合物的药物组合物,用于制备这些化合物的方法和中间体以及使用这些化合物治疗肺部疾病的方法。
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