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公开(公告)号：US20140249135A1
公开(公告)日：2014-09-04
申请号：US14273595
申请日：2014-05-09
申请人： Matthew Burger , Mika Lindvall , Wooseok Han , Jiong Lan , Gisele Nishiguchi , Cynthia Shafer , Cornelia Bellamacina , Kay Huh , Gordana Atallah , Christopher McBride , William Antonios-McCrea, JR. , Tatiana Zavorotinskaya , Annette Walter , Pablo Dominguez Garcia
发明人： Matthew Burger , Mika Lindvall , Wooseok Han , Jiong Lan , Gisele Nishiguchi , Cynthia Shafer , Cornelia Bellamacina , Kay Huh , Gordana Atallah , Christopher McBride , William Antonios-McCrea, JR. , Tatiana Zavorotinskaya , Annette Walter , Pablo Dominguez Garcia
IPC分类号： C07D401/12 , A61K31/55 , A61K31/497 , A61K31/4545 , A61K31/444 , C07D491/113 , C07D403/12 , A61K31/506 , C07D241/28 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D497/04 , C07D403/14 , A61K31/553
CPC分类号： C07D401/12 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K31/55 , A61K31/553 , C07D241/24 , C07D241/28 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D491/113 , C07D497/04
摘要： New compounds, compositions and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.
摘要翻译： 提供了在人或动物受试者中抑制与肿瘤发生相关的激酶活性的新化合物，组合物和方法。 在某些实施方案中，化合物和组合物有效抑制至少一种丝氨酸/苏氨酸激酶或受体酪氨酸激酶的活性。 新化合物和组合物可以单独使用或与至少一种另外的药剂组合使用，用于治疗丝氨酸/苏氨酸激酶或受体酪氨酸激酶介导的病症，例如癌症。
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公开(公告)号：US08822497B2
公开(公告)日：2014-09-02
申请号：US12449701
申请日：2008-03-03
申请人： Matthew Burger , Mika Lindvall , Wooseok Han , Jiong Lan , Gisele Nishiguchi , Cynthia Shafer , Cornelia Bellamacina , Kay Huh , Gordana Atallah , Christopher McBride , William Antonios-McCrea, Jr. , Tatiana Zavorotinskaya , Annette Walter , Pablo Garcia
发明人： Matthew Burger , Mika Lindvall , Wooseok Han , Jiong Lan , Gisele Nishiguchi , Cynthia Shafer , Cornelia Bellamacina , Kay Huh , Gordana Atallah , Christopher McBride , William Antonios-McCrea, Jr. , Tatiana Zavorotinskaya , Annette Walter , Pablo Garcia
IPC分类号： A61K31/4545 , C07D401/14
CPC分类号： C07D401/12 , C07D213/78 , C07D239/28
摘要： New compounds, compositions and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.
摘要翻译： 提供了在人或动物受试者中抑制与肿瘤发生相关的激酶活性的新化合物，组合物和方法。 在某些实施方案中，化合物和组合物有效地抑制至少一种丝氨酸/苏氨酸激酶或受体酪氨酸激酶的活性。 新化合物和组合物可以单独使用或与至少一种另外的药剂组合使用，用于治疗丝氨酸/苏氨酸激酶或受体酪氨酸激酶介导的病症，例如癌症。
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公开(公告)号：US20120208815A1
公开(公告)日：2012-08-16
申请号：US12449701
申请日：2008-03-03
申请人： Matthew Burger , Mika Lindvall , Wooseok Han , Jiong Lan , Gisele Nishiguchi , Cynthia Shafer , Comelia Bellamacina , Kay Huh , Gordana Atallah , Christopher Mcbride , William Antonios-Mccrea, JR. , Tatiana Zavorotinskaya , Annette Walter , Pablo Garcia
发明人： Matthew Burger , Mika Lindvall , Wooseok Han , Jiong Lan , Gisele Nishiguchi , Cynthia Shafer , Comelia Bellamacina , Kay Huh , Gordana Atallah , Christopher Mcbride , William Antonios-Mccrea, JR. , Tatiana Zavorotinskaya , Annette Walter , Pablo Garcia
IPC分类号： A61K31/5377 , A61K31/4545 , A61P35/00 , C07D413/14 , A61K31/496 , C07D417/14 , A61K31/506 , A61K31/497 , C07D401/14 , C12N5/071
CPC分类号： C07D401/12 , C07D213/78 , C07D239/28
摘要： New compounds, compositions and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.
摘要翻译： 提供了在人或动物受试者中抑制与肿瘤发生相关的激酶活性的新化合物，组合物和方法。 在某些实施方案中，化合物和组合物有效抑制至少一种丝氨酸/苏氨酸激酶或受体酪氨酸激酶的活性。 新化合物和组合物可以单独使用或与至少一种另外的药剂组合使用，用于治疗丝氨酸/苏氨酸激酶或受体酪氨酸激酶介导的病症，例如癌症。
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4.发明授权Stable envelope proteins for retroviral, viral and liposome vectors and use in gene drug therapy 失效用于逆转录病毒，病毒和脂质体载体的稳定的包膜蛋白，用于基因药物治疗公开(公告)号：US06448390B1
公开(公告)日：2002-09-10
申请号：US09315127
申请日：1999-05-20
IPC分类号： C07H2104
CPC分类号： C07K14/005 , C12N7/00 , C12N15/86 , C12N15/88 , C12N2740/13022 , C12N2740/13043 , C12N2740/13045 , C12N2740/13062 , C12N2810/50 , C12N2810/6054
摘要： This invention includes retrovirus envelope mutants into which heterologous peptide or glycopeptide sequences can be linked for expression and stable presentation on retroviral vectors. The envelope mutants are characterized by the ability to restore the target penetration capability that is lost or greatly diminished upon fusion of heterologous sequences to the wild type envelope protein and the ability to increase the fusion envelope protein stability and decrease envelope shedding from virus particles. The envelope mutants are created by rotating residues in at least one of 7 motifs. The disclosed envelope proteins also can be used in liposome or pseudotype-virus compositions for delivery of agents including nucleic acid molecules. Methods of preparing and utilizing these envelope mutants in gene therapy are also described.
摘要翻译： 本发明包括逆转录病毒包膜突变体，异源肽或糖肽序列可以连接到逆转录病毒包膜突变体上，用于在逆转录病毒载体上表达和稳定表达。 信封突变体的特征在于恢复在异源序列融合到野生型包膜蛋白时丢失或大大减少的靶穿透能力的能力，以及增加融合包膜蛋白稳定性并减少病毒颗粒的包膜脱落的能力。 通过在7个图案中的至少一个中旋转残基来产生包膜突变体。 所公开的包膜蛋白也可用于脂质体或假型病毒组合物中用于递送包括核酸分子的试剂。 还描述了在基因治疗中制备和利用这些包膜突变体的方法。
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