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公开(公告)号:US20120225061A1
公开(公告)日:2012-09-06
申请号:US13410203
申请日:2012-03-01
申请人: Matthew Burger , Yu Ding , Wooseok Han , Gisele Nishiguchi , Alice Rico , Robert Lowell Simmons , Aaron R. Smith , Victoriano Tamez, JR. , Huw Tanner , Lifeng Wan
发明人: Matthew Burger , Yu Ding , Wooseok Han , Gisele Nishiguchi , Alice Rico , Robert Lowell Simmons , Aaron R. Smith , Victoriano Tamez, JR. , Huw Tanner , Lifeng Wan
IPC分类号: A61K31/444 , A61K31/506 , A61K31/497 , C07D413/14 , A61K31/5377 , A61K31/4745 , A61K31/7068 , A61K31/513 , A61K31/704 , A61K31/519 , A61K33/24 , A61K31/664 , A61K39/395 , A61P35/00 , A61P35/02 , A61P37/00 , A61P1/00 , C07D401/12
CPC分类号: A61K31/4439 , A61K31/444 , A61K31/4745 , A61K31/497 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/664 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K39/395 , A61K45/06 , C07D213/81 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , A61K2300/00
摘要: The present invention provides a compound of formula (I): as further described herein, and pharmaceutically acceptable salts, enantiomers, rotamers, tautomers, or racemates thereof. Also provided are methods of treating a disease or condition mediated by PIM kinase using the compounds of Formula I, and pharmaceutical compositions comprising such compounds.
摘要翻译: 本发明提供式(I)化合物:如本文进一步描述的,及其药学上可接受的盐,对映异构体,旋转异构体,互变异构体或外消旋体。 还提供了使用式I化合物治疗PIM激酶介导的疾病或病症的方法和包含这些化合物的药物组合物。
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公开(公告)号:US20120225062A1
公开(公告)日:2012-09-06
申请号:US13410845
申请日:2012-03-02
申请人: Matthew Burger , Gisele Nishiguchi , Timothy D. Machajewski , Alice Rico , Robert Lowell Simmons , Aaron R. Smith , Victoriano Tamez, JR. , Huw Tanner , Lifeng Wan
发明人: Matthew Burger , Gisele Nishiguchi , Timothy D. Machajewski , Alice Rico , Robert Lowell Simmons , Aaron R. Smith , Victoriano Tamez, JR. , Huw Tanner , Lifeng Wan
IPC分类号: C07D401/12 , A61K31/444 , A61K31/4545 , C07D413/14 , A61K31/4375 , A61K31/7068 , A61K31/513 , A61K31/351 , A61K31/519 , A61K31/282 , A61K33/24 , A61K31/675 , A61K31/506 , A61K31/165 , A61P35/04 , A61K35/02 , A61P37/00 , A61P1/04 , A61P19/02 , C07D401/14
CPC分类号: C07D213/75 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要: The present invention provides compounds of Formula I: and related compounds as further described herein, and pharmaceutical compositions comprising these compounds. The invention further provides methods to use these compounds and compositions for treating disorders associated with undesired levels of Pim kinase activity, including cancers and autoimmune disorders.
摘要翻译: 本发明提供了式I化合物和本文进一步描述的相关化合物,以及包含这些化合物的药物组合物。 本发明进一步提供了使用这些化合物和组合物治疗与不希望的Pim激酶活性水平相关的疾病(包括癌症和自身免疫性疾病)的方法。
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公开(公告)号:US20100144730A1
公开(公告)日:2010-06-10
申请号:US12307104
申请日:2007-07-02
申请人: Kenneth Egnard Lind , Kathy Cao , Edward Yin-shiang Lin , Thinh Ba Nguyen , Bradley T. Tangonan , Daniel A. Erlanson , Kevin Guckian , Robert Lowell Simmons , Wen-cherng Lee , Lihong Sun , Stig Hansen , Nuzhat Pathan , Lei Zhang
发明人: Kenneth Egnard Lind , Kathy Cao , Edward Yin-shiang Lin , Thinh Ba Nguyen , Bradley T. Tangonan , Daniel A. Erlanson , Kevin Guckian , Robert Lowell Simmons , Wen-cherng Lee , Lihong Sun , Stig Hansen , Nuzhat Pathan , Lei Zhang
IPC分类号: A61K31/437 , C07D471/04 , C07D487/04 , C07D413/14 , A61K31/519 , A61K31/5377 , A61P35/00
CPC分类号: C07D471/04 , A61K31/4412 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5377 , C07D211/86 , C07D213/64 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04
摘要: The present invention provides pyridinonyl PDK1 inhibitors and methods of treating cancer using the same.
摘要翻译: 本发明提供吡啶基PDK1抑制剂和使用其制备癌症的方法。
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4.
公开(公告)号:US09174978B2
公开(公告)日:2015-11-03
申请号:US14665245
申请日:2015-03-23
申请人: Virender Singh Aulakh , Anthony Casarez , Xiaodong Lin , Mika Lindvall , Glenn McEnroe , Heinz Ernst Moser , Folkert Reck , Meiliana Tjandra , Robert Lowell Simmons , Aregahegn Yifru , Qingming Zhu
发明人: Virender Singh Aulakh , Anthony Casarez , Xiaodong Lin , Mika Lindvall , Glenn McEnroe , Heinz Ernst Moser , Folkert Reck , Meiliana Tjandra , Robert Lowell Simmons , Aregahegn Yifru , Qingming Zhu
IPC分类号: A61K31/40 , C07D417/14 , A61K31/427 , A61K31/454 , A61K31/4439 , A61K31/433 , A61K31/496 , A61K31/4545 , C07D487/04 , A61K45/06
CPC分类号: A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K45/06 , C07D417/14 , C07D487/04 , Y02A50/473 , Y02A50/481
摘要: This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.
摘要翻译: 本发明一般涉及本文进一步描述的式I抗菌化合物及其药学上可接受的盐和制剂。 在某些方面,本发明涉及使用这些化合物治疗诸如革兰氏阴性菌引起的感染的方法。
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公开(公告)号:US08778977B2
公开(公告)日:2014-07-15
申请号:US12307104
申请日:2007-07-02
申请人: Kenneth Egnard Lind , Kathy Cao , Edward Yin-shiang Lin , Thinh Ba Nguyen , Bradley T. Tangonan , Daniel A. Erlanson , Kevin Guckian , Robert Lowell Simmons , Wen-cherng Lee , Lihong Sun , Stig Hansen , Nuzhat Pathan , Lei Zhang
发明人: Kenneth Egnard Lind , Kathy Cao , Edward Yin-shiang Lin , Thinh Ba Nguyen , Bradley T. Tangonan , Daniel A. Erlanson , Kevin Guckian , Robert Lowell Simmons , Wen-cherng Lee , Lihong Sun , Stig Hansen , Nuzhat Pathan , Lei Zhang
IPC分类号: A61K31/5377 , A61K31/506 , A61K31/519 , A61K31/4985 , A61K31/444 , A61K31/4439 , A61K31/4436 , A61K31/443 , A61K31/4412 , C07D487/04 , C07D471/04 , C07D417/14 , C07D417/12 , C07D413/14 , C07D413/12 , C07D409/14 , C07D409/12 , C07D405/14 , C07D405/12 , C07D401/14 , C07D401/12 , C07D211/86
CPC分类号: C07D471/04 , A61K31/4412 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5377 , C07D211/86 , C07D213/64 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04
摘要: The present invention provides pyridinonyl PDK1 inhibitors and methods of treating cancer using the same.
摘要翻译: 本发明提供吡啶基PDK1抑制剂和使用其制备癌症的方法。
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