-
公开(公告)号:US08217035B2
公开(公告)日:2012-07-10
申请号:US12161537
申请日:2007-01-22
申请人: Matthew Burger , Zhi-Jie Ni , Sabina Pecchi , Gordana Atallah , Sarah Bartulis , Kelly Frazier , Aaron Smith , Joelle Verhagen , Yanchen Zhang , Allan Wagman , Simon Ng , Keith Pfister , Daniel Poon , Alicia Louie , Teresa Pick , Paul Barsanti , Edwin Iwanowicz , Wendy Fantl , Thomas Hendrickson , Mark Knapp , Hanne Merritt , Charles Voliva , Marion Wiesmann , Xiaohua Xin
发明人: Matthew Burger , Zhi-Jie Ni , Sabina Pecchi , Gordana Atallah , Sarah Bartulis , Kelly Frazier , Aaron Smith , Joelle Verhagen , Yanchen Zhang , Allan Wagman , Simon Ng , Keith Pfister , Daniel Poon , Alicia Louie , Teresa Pick , Paul Barsanti , Edwin Iwanowicz , Wendy Fantl , Thomas Hendrickson , Mark Knapp , Hanne Merritt , Charles Voliva , Marion Wiesmann , Xiaohua Xin
IPC分类号: A61K31/535 , C07D413/14
CPC分类号: C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12
摘要: Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
摘要翻译: 磷脂酰肌醇(PI)3-激酶抑制剂化合物(I),其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗以生长因子,蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性为特征的增殖性疾病中的用途。
-
2.
公开(公告)号:US20100004237A1
公开(公告)日:2010-01-07
申请号:US12462302
申请日:2009-07-31
申请人: Timothy D. Machakewski , Cynthia M. Shafer , Christopher McBride , William Antonios-McCrea , Brandon M. Doughan , Barry H. Levine , Yi Xia , Maureen McKenna , X. Michael Wang , Kris Mendenhall , Yasheen Zhou , Baoqing Gong , Dan Gu , John Dolan , John Tulinsky , Kristin Brinner , Zhenhai Gao , Daniel Poon , Paul Barsanti , Xiaodong Lin , Abran Costales , Alice Rico , Nathan Brammeier , Teresa Pick , Paul A. Renhowe
发明人: Timothy D. Machakewski , Cynthia M. Shafer , Christopher McBride , William Antonios-McCrea , Brandon M. Doughan , Barry H. Levine , Yi Xia , Maureen McKenna , X. Michael Wang , Kris Mendenhall , Yasheen Zhou , Baoqing Gong , Dan Gu , John Dolan , John Tulinsky , Kristin Brinner , Zhenhai Gao , Daniel Poon , Paul Barsanti , Xiaodong Lin , Abran Costales , Alice Rico , Nathan Brammeier , Teresa Pick , Paul A. Renhowe
IPC分类号: C07D471/04 , A61K31/5377 , A61K31/497 , A61K31/519
CPC分类号: C07D211/86 , C07D471/04
摘要: Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nervous system diseases.
摘要翻译: 公开了2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物,其立体异构体,互变异构体,其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物的组合物,单独或与至少一种额外的 治疗剂。 还公开了将2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物单独使用或与至少一种另外的治疗剂组合使用的方法,用于预防 或治疗细胞增殖,病毒,自身免疫,心血管和中枢神经系统疾病。
-
3.
公开(公告)号:US07671059B2
公开(公告)日:2010-03-02
申请号:US11541462
申请日:2006-09-28
申请人: Timothy D. Machajewski , Cynthia M. Shafer , Christopher McBride , William Antonios-McCrea , Brandon M. Doughan , Barry H. Levine , Yi Xia , Maureen McKenna , X. Michael Wang , Kris Mendenhall , Yasheen Zhou , Kristin Brinner , Zhenhai Gao , Daniel Poon , Paul Barsanti , Xiaodong Lin , Abran Costales , Alice Rico , Nathan Brammeier , Teresa Pick , Paul A. Renhowe
发明人: Timothy D. Machajewski , Cynthia M. Shafer , Christopher McBride , William Antonios-McCrea , Brandon M. Doughan , Barry H. Levine , Yi Xia , Maureen McKenna , X. Michael Wang , Kris Mendenhall , Yasheen Zhou , Kristin Brinner , Zhenhai Gao , Daniel Poon , Paul Barsanti , Xiaodong Lin , Abran Costales , Alice Rico , Nathan Brammeier , Teresa Pick , Paul A. Renhowe
IPC分类号: A61K31/519 , A61K31/5355 , C07D471/04 , C07D487/04 , C07D413/06 , A61P35/00
CPC分类号: C07D211/86 , C07D471/04
摘要: Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nervous system diseases.
摘要翻译: 公开了2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物,其立体异构体,互变异构体,其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物的组合物,单独或与至少一种额外的 治疗剂。 还公开了将2-氨基-7,8-二氢-6H-吡啶并[4,3-d]嘧啶-5-酮化合物单独使用或与至少一种另外的治疗剂组合使用的方法,用于预防 或治疗细胞增殖,病毒,自身免疫,心血管和中枢神经系统疾病。
-
公开(公告)号:US08563553B2
公开(公告)日:2013-10-22
申请号:US13473230
申请日:2012-05-16
申请人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew
发明人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew
IPC分类号: A61K31/50
CPC分类号: C07D403/04 , A61K31/506 , A61K45/06
摘要: The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要翻译: 本发明提供式I或II的化合物:其中R1,R1b,R2,R3,R4,R5,R6和R7如本文所定义。 式(I)或(II)的化合物及其药物组合物可用于治疗B-Raf相关疾病。
-
公开(公告)号:US20120225899A1
公开(公告)日:2012-09-06
申请号:US13473230
申请日:2012-05-16
申请人: Abran Q. Costales , Shenlin Huang , Jeff (Xianming) Jin , Zhuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
发明人: Abran Q. Costales , Shenlin Huang , Jeff (Xianming) Jin , Zhuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
IPC分类号: A61K31/506 , A61P35/00
CPC分类号: C07D403/04 , A61K31/506 , A61K45/06
摘要: The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要翻译: 本发明提供式I或II的化合物:其中R1,R1b,R2,R3,R4,R5,R6和R7如本文所定义。 式(I)或(II)的化合物及其药物组合物可用于治疗B-Raf相关疾病。
-
公开(公告)号:US08242260B2
公开(公告)日:2012-08-14
申请号:US12862418
申请日:2010-08-24
申请人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
发明人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
IPC分类号: C07D345/00 , C07D239/00 , C07D233/00
CPC分类号: C07D403/04 , A61K31/506 , A61K45/06
摘要: The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要翻译: 本发明提供式I或II的化合物:其中R1,R1b,R2,R3,R4,R5,R6和R7如本文所定义。 式(I)或(II)的化合物及其药物组合物可用于治疗B-Raf相关疾病。
-
公开(公告)号:US09242996B2
公开(公告)日:2016-01-26
申请号:US14527328
申请日:2014-10-29
申请人: Jeffrey T. Bagdanoff , Yu Ding , Wooseok Han , Zilin Huang , Qun Jiang , Jeff Xianming Jin , Xiang Kou , Patrick Lee , Mika Lindvall , Zhongcheng Min , Yue Pan , Sabina Pecchi , Keith Bruce Pfister , Daniel Poon , Vivek Rauniyar , Xiaojing Michael Wang , Qiong Zhang , Jianguang Zhou , Shejin Zhu
发明人: Jeffrey T. Bagdanoff , Yu Ding , Wooseok Han , Zilin Huang , Qun Jiang , Jeff Xianming Jin , Xiang Kou , Patrick Lee , Mika Lindvall , Zhongcheng Min , Yue Pan , Sabina Pecchi , Keith Bruce Pfister , Daniel Poon , Vivek Rauniyar , Xiaojing Michael Wang , Qiong Zhang , Jianguang Zhou , Shejin Zhu
IPC分类号: C07D213/73 , C07D401/06 , C07D403/06 , C07D498/04 , A61K31/4436 , A61K31/4545 , A61K31/4439 , A61K31/4965 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K45/06 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D401/12
CPC分类号: A61K31/497 , A61K31/44 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/4965 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K45/06 , A61K2121/00 , C07D213/73 , C07D241/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D498/04
摘要: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
摘要翻译: 本发明提供式(I)的化合物或其盐; 和这些化合物的治疗用途。 本发明还提供包含这些化合物的药物组合物,以及包含这些化合物与治疗性助剂的组合物。
-
公开(公告)号:US08859548B2
公开(公告)日:2014-10-14
申请号:US14022540
申请日:2013-09-10
申请人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
发明人: Abran Q. Costales , Shenlin Huang , Jeff Xianming Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew , Qiong Zhang
IPC分类号: A61K31/50 , A61K45/06 , A61K31/506 , C07D403/04
CPC分类号: C07D403/04 , A61K31/506 , A61K45/06
摘要: The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要翻译: 本发明提供式I或II的化合物:其中R1,R1b,R2,R3,R4,R5,R6和R7如本文所定义。 式(I)或(II)的化合物及其药物组合物可用于治疗B-Raf相关疾病。
-
公开(公告)号:US20110052578A1
公开(公告)日:2011-03-03
申请号:US12862418
申请日:2010-08-24
申请人: Abran Q. Costales , Shenlin Huang , Jeff (Xianming) Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew
发明人: Abran Q. Costales , Shenlin Huang , Jeff (Xianming) Jin , Zuosheng Liu , Sabina Pecchi , Daniel Poon , John Tellew
IPC分类号: A61K39/395 , C07D401/04 , A61K31/506 , A61P35/00 , A61P37/00
CPC分类号: C07D403/04 , A61K31/506 , A61K45/06
摘要: The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要翻译: 本发明提供式I或II的化合物:其中R1,R1b,R2,R3,R4,R5,R6和R7如本文所定义。 式(I)或(II)的化合物及其药物组合物可用于治疗B-Raf相关疾病。
-
公开(公告)号:US09763937B2
公开(公告)日:2017-09-19
申请号:US14964057
申请日:2015-12-09
申请人: Jeffrey T. Bagdanoff , Yu Ding , Wooseok Han , Zilin Huang , Qun Jiang , Xianming Jin , Xiang Kou , Patrick Lee , Mika Lindvall , Zhongcheng Min , Yue Pan , Sabina Pecchi , Keith Bruce Pfister , Daniel Poon , Vivek Rauniyar , Xiaojing Michael Wang , Qiong Zhang , Jianguang Zhou , Shejin Zhu
发明人: Jeffrey T. Bagdanoff , Yu Ding , Wooseok Han , Zilin Huang , Qun Jiang , Xianming Jin , Xiang Kou , Patrick Lee , Mika Lindvall , Zhongcheng Min , Yue Pan , Sabina Pecchi , Keith Bruce Pfister , Daniel Poon , Vivek Rauniyar , Xiaojing Michael Wang , Qiong Zhang , Jianguang Zhou , Shejin Zhu
IPC分类号: C07D241/02 , A61K31/4965 , A61K31/497 , A61K31/4433 , A61K31/44 , A61K31/4436 , A61K31/5355
CPC分类号: A61K31/497 , A61K31/44 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/4965 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K45/06 , A61K2121/00 , C07D213/73 , C07D241/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/14 , C07D498/04
摘要: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
-
-
-
-
-
-
-
-
-