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公开(公告)号:US20120302542A1
公开(公告)日:2012-11-29
申请号:US13306581
申请日:2011-11-29
申请人: Matthew F. Brown , Mark J. Mitton-Fry , Seungil Han , Manjinder Lall , Mark Plummer , Hud Lawrence Risley , Veerabahu Shanmugasundaram , Jeremy Starr
发明人: Matthew F. Brown , Mark J. Mitton-Fry , Seungil Han , Manjinder Lall , Mark Plummer , Hud Lawrence Risley , Veerabahu Shanmugasundaram , Jeremy Starr
IPC分类号: A61K31/4439 , A61P31/04 , C07D417/14
CPC分类号: C07D417/14 , C07D205/08
摘要: The present invention is directed to a new class of monobactam derivatives and their use for treating bacterial infections.
摘要翻译: 本发明涉及一类新颖的单链内酰胺衍生物及其用于治疗细菌感染的用途。
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2.COMPOUNDS HAVING BOTH ANGIOTENSIN II RECEPTOR ANTAGONISM AND PPARy ACTIVATING ACTIVITIES 审中-公开
标题翻译: 具有两种血管紧张素II受体拮抗剂和PPAR活性活性的化合物公开(公告)号:US20100029710A1
公开(公告)日:2010-02-04
申请号:US12518472
申请日:2007-12-03
申请人: Christopher Franklin Bigge , Agustin Casimiro-Garcia , Chitase Lee , Hud Lawrence Risley , Robert Philip Schaum
发明人: Christopher Franklin Bigge , Agustin Casimiro-Garcia , Chitase Lee , Hud Lawrence Risley , Robert Philip Schaum
IPC分类号: A61K31/437 , C07D471/04 , A61P3/10 , A61P3/00 , A61P9/12
CPC分类号: C07D471/04
摘要: Compounds of following formula (I) are provided that have both angiotensin II receptor antagonist activity and PPARy agonist activity. Also provided are pharmaceutical compositions comprising the compounds and methods of treatment of diseases with the compounds including type 2 diabetes, insulin resistance, hyperinsulinemia, hyperlipidemia, hypertriglyceridemia, metabolic syndrome, congestive heart failure, and hypertension.
摘要翻译: 提供了具有血管紧张素II受体拮抗剂活性和PPARγ激动剂活性的下式(I)的化合物。 还提供了包含该化合物的药物组合物和用包括2型糖尿病,胰岛素抵抗,高胰岛素血症,高脂血症,高甘油三酯血症,代谢综合征,充血性心力衰竭和高血压的化合物治疗疾病的方法。
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