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1.Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation 失效
标题翻译: 螺环化合物作为纤维蛋白原依赖性血小板聚集的抑制剂公开(公告)号:US06693109B2
公开(公告)日:2004-02-17
申请号:US10354265
申请日:2003-01-29
申请人: Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffrey T. Mullaney , Michael Paal , Gerd Ruhter , Kenneth J. Ruterbories , Robert M. Scarborough , Theo Schotten , Wolfgang Stenzel
发明人: Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffrey T. Mullaney , Michael Paal , Gerd Ruhter , Kenneth J. Ruterbories , Robert M. Scarborough , Theo Schotten , Wolfgang Stenzel
IPC分类号: C07D22120
CPC分类号: C07D221/20 , A61K31/423 , A61K31/437 , C07D263/52 , C07D471/10
摘要: This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
摘要翻译: 本发明涉及用碱性和酸性官能团取代的某些螺环化合物,其可用于抑制血小板聚集。
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公开(公告)号:US06528534B2
公开(公告)日:2003-03-04
申请号:US09899886
申请日:2001-07-06
申请人: Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffrey T. Mullaney , Kenneth J. Ruterbories , Michael Paal , Gerd Ruhter , Theo Schotten , Wolfgang Stenzel , Robert M. Scarborough
发明人: Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffrey T. Mullaney , Kenneth J. Ruterbories , Michael Paal , Gerd Ruhter , Theo Schotten , Wolfgang Stenzel , Robert M. Scarborough
IPC分类号: C07D26352
CPC分类号: C07D221/20 , A61K31/423 , A61K31/437 , C07D263/52 , C07D471/10
摘要: This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
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3.Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation 有权
标题翻译: 螺环化合物作为纤维蛋白原依赖性血小板聚集的抑制剂公开(公告)号:US06291469B1
公开(公告)日:2001-09-18
申请号:US09043846
申请日:1998-10-05
申请人: Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffrey T. Mullaney , Kenneth J. Ruterbories , Michael Paal , Gerd Ruhter , Robert M. Scarborough , Theo Schotten , Wolfgang Stenzel
发明人: Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffrey T. Mullaney , Kenneth J. Ruterbories , Michael Paal , Gerd Ruhter , Robert M. Scarborough , Theo Schotten , Wolfgang Stenzel
IPC分类号: C07D22120
CPC分类号: C07D221/20 , A61K31/423 , A61K31/437 , C07D263/52 , C07D471/10
摘要: This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, as shown by formula (I): wherein Q, L, Ai, Bj, R0, R3, R10, m, n, p and q are as defined in the disclosure, which are useful in inhibiting of platelet aggregation.
摘要翻译: 本发明涉及由碱式和酸性官能团取代的某些螺环化合物,如式(I)所示:其中Q,L,Ai,Bj,R 0,R 3,R 10,m,n,p和q如 可用于抑制血小板聚集。
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公开(公告)号:US06552079B2
公开(公告)日:2003-04-22
申请号:US09855448
申请日:2001-05-15
申请人: Robert M. Scarborough , Mark Smyth , Ting Su , Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffry Bernard Franciskovich
发明人: Robert M. Scarborough , Mark Smyth , Ting Su , Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffry Bernard Franciskovich
IPC分类号: C07C31104
CPC分类号: C07D211/62 , C07C311/06 , C07C311/19 , C07C2601/14
摘要: Novel compounds, their salts and compositions related thereto having activity against mammalian integrins are disclosed. The compounds are useful in vitro or in vivo for preventing or treating thrombotic or restenotic disorders.
摘要翻译: 公开了与哺乳动物整联蛋白有关的新型化合物,其盐和与其有关的组合物。 该化合物在体外或体内可用于预防或治疗血栓形成或再狭窄病症。
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公开(公告)号:US06245809B1
公开(公告)日:2001-06-12
申请号:US09328197
申请日:1999-06-08
申请人: Robert M. Scarborough , Mark Smyth , Ting Su , Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffry Bernard Franciskovich
发明人: Robert M. Scarborough , Mark Smyth , Ting Su , Matthew J. Fisher , Joseph A. Jakubowski , John J. Masters , Jeffry Bernard Franciskovich
IPC分类号: C07C31104
CPC分类号: C07D211/62 , C07C311/06 , C07C311/19 , C07C2601/14
摘要: Novel compounds, their salts and compositions related thereto having activity against mammalian integrins are disclosed. The compounds are useful in vitro or in vivo for preventing or treating thrombotic or restenotic disorders.
摘要翻译: 公开了与哺乳动物整联蛋白有关的新型化合物,其盐和与其有关的组合物。 该化合物在体外或体内可用于预防或治疗血栓形成或再狭窄病症。
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公开(公告)号:US5488116A
公开(公告)日:1996-01-30
申请号:US146704
申请日:1993-11-02
申请人: Samuel J. Danishefsky , William G. Bornmann , Yves Queneau , Thomas V. Magee , Walter J. Krol , John J. Masters , David K. Jung
发明人: Samuel J. Danishefsky , William G. Bornmann , Yves Queneau , Thomas V. Magee , Walter J. Krol , John J. Masters , David K. Jung
IPC分类号: A61K31/335 , C07C13/28 , C07C45/29 , C07C45/59 , C07C49/603 , C07C49/613 , C07C49/687 , C07C49/713 , C07C49/723 , C07C49/737 , C07C49/747 , C07C49/753 , C07C49/757 , C07C255/31 , C07C255/45 , C07C255/46 , C07D305/14 , C07D317/72 , C07D339/08 , C07D493/04 , C07F7/18 , C07D317/70
CPC分类号: C07F7/1856 , C07C255/31 , C07C255/46 , C07C403/08 , C07C403/14 , C07C403/16 , C07C403/20 , C07C45/29 , C07C45/59 , C07C49/613 , C07C49/687 , C07C49/713 , C07C49/723 , C07C49/737 , C07C49/747 , C07C49/753 , C07C49/757 , C07D305/14 , C07D317/72 , C07F7/1852 , C07C2101/14 , C07C2101/16
摘要: The present invention provides three basic routes for the total synthesis of taxol having the structure: ##STR1## The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates as well as analogues of taxol and nortaxol.
摘要翻译: 本发明提供了具有以下结构的紫杉醇的总合成的三种基本途径:本发明还提供了上述方法中制备的中间体,合成这些中间体的方法以及紫杉醇和北美多酚的类似物。
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