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    Method for ultrasound vibrometry using orthogonal basis functions
    4.
    发明授权
    Method for ultrasound vibrometry using orthogonal basis functions 有权
    使用正交基函数的超声波振幅测量方法

    公开(公告)号：US08602994B2

    公开(公告)日：2013-12-10

    申请号：US13254227

    申请日：2010-03-09

    申请人： Yi Zheng ,  Aiping Yao ,  James F. Greenleaf ,  Shigao Chen ,  Matthew W. Urban

    发明人： Yi Zheng ,  Aiping Yao ,  James F. Greenleaf ,  Shigao Chen ,  Matthew W. Urban

    IPC分类号： A61B8/00 ,  G01H1/00

    CPC分类号： G01S7/52036 ,  A61B8/485 ,  G01S7/52022 ,  G01S15/8952

    摘要： A method for measuring a mechanical property of a subject includes using an ultrasound transducer to apply ultrasonic vibration pulses to a location in a subject in order to induce shear waves at multiple prescribed orthogonal frequencies in the subject. The ultrasound transducer is directed by an excitation signal that is composed of multiple orthogonal basis functions, each having a given frequency component corresponding to the prescribed orthogonal frequencies. The power level of each orthogonal basis function is independently adjustable. The excitation signal can be sparsely sampled, or portions of the excitation signal can be removed in order to improve tissue vibration and to provide for the interleaving ultrasonic vibration and detection pulses. Ultrasonic detection pulses are applied to at least one motion detection point, from which echo signals are received. From the received echo signals, a motion signal is determined, from which mechanical properties of the subject are calculated.

    摘要翻译： 用于测量受试者的机械性质的方法包括使用超声波换能器将超声波振动脉冲施加到受试者中的位置，以便在受试者中以多个规定的正交频率诱发剪切波。 超声换能器由多个正交基函数组成的激励信号引导，每个正交基函数具有对应于规定正交频率的给定频率分量。 每个正交基函数的功率电平是独立可调的。 励磁信号可以被稀疏地采样，或者可以去除激励信号的部分，以便改善组织振动并提供交织超声波振动和检测脉冲。 超声波检测脉冲被施加到至少一个运动检测点，从该运动检测点接收回波信号。 从所接收的回波信号中，确定运动信号，从而计算被摄体的机械性质。

    System and Method for Model-Independent Quantification of Tissue Viscoelastic Properties Using Ultrasound
    5.
    发明申请
    System and Method for Model-Independent Quantification of Tissue Viscoelastic Properties Using Ultrasound 审中-公开
    使用超声波模型独立定量组织粘弹性的系统和方法

    公开(公告)号：US20130237821A1

    公开(公告)日：2013-09-12

    申请号：US13795199

    申请日：2013-03-12

    申请人： Carolina Amador Carrascal ,  Matthew W. Urban ,  Shigao Chen ,  James F. Greenleaf

    发明人： Carolina Amador Carrascal ,  Matthew W. Urban ,  Shigao Chen ,  James F. Greenleaf

    IPC分类号： A61B8/08

    CPC分类号： A61B8/485 ,  A61B8/085 ,  A61B8/5223 ,  G01S7/52042

    摘要： A model-independent method for producing a viscoelastic tissue property metric using ultrasound is provided. A mechanical stress, such as an acoustic force, is applied to a tissue using an ultrasound system and tissue displacement resulting from the applied acoustic force is measured. From the tissue displacement measurements, a complex modulus, such as a relative complex modulus, is extracted. A loss tangent is calculated from the extracted complex modulus. Using the calculated loss tangent, viscoelastic tissue property metrics may be calculated.

    摘要翻译： 提供了一种使用超声波产生粘弹性组织性能量度的模型无关方法。 使用超声系统将机械应力（例如声力）施加到组织，并且测量由施加的声力引起的组织位移。 从组织位移测量中，提取复数模量，例如相对复数模量。 从提取的复数模数计算损耗角正切值。 使用计算的损耗角正切，可以计算粘弹性组织性质指标。

    Method for Ultrasound Vibrometry Using Orthogonal Basis Functions
    7.
    发明申请
    Method for Ultrasound Vibrometry Using Orthogonal Basis Functions 有权
    使用正交基函数的超声波振幅法

    公开(公告)号：US20110319756A1

    公开(公告)日：2011-12-29

    申请号：US13254227

    申请日：2010-03-09

    申请人： Yi Zheng ,  Aiping Yao ,  James F. Greenleaf ,  Shigao Chen ,  Matthew W. Urban

    发明人： Yi Zheng ,  Aiping Yao ,  James F. Greenleaf ,  Shigao Chen ,  Matthew W. Urban

    IPC分类号： A61B8/00

    CPC分类号： G01S7/52036 ,  A61B8/485 ,  G01S7/52022 ,  G01S15/8952

    摘要： A method for measuring a mechanical property of a subject includes using an ultrasound transducer to apply ultrasonic vibration pulses to a location in a subject in order to induce shear waves at multiple prescribed orthogonal frequencies in the subject. The ultrasound transducer is directed by an excitation signal that is composed of multiple orthogonal basis functions, each having a given frequency component corresponding to the prescribed orthogonal frequencies. The power level of each orthogonal basis function is independently adjustable. The excitation signal can be sparsely sampled, or portions of the excitation signal can be removed in order to improve tissue vibration and to provide for the interleaving ultrasonic vibration and detection pulses. Ultrasonic detection pulses are applied to at least one motion detection point, from which echo signals are received. From the received echo signals, a motion signal is determined, from which mechanical properties of the subject are calculated.

    摘要翻译： 用于测量受试者的机械性质的方法包括使用超声波换能器将超声波振动脉冲施加到受试者中的位置，以便在受试者中以多个规定的正交频率诱发剪切波。 超声换能器由多个正交基函数组成的激励信号引导，每个正交基函数具有对应于规定正交频率的给定频率分量。 每个正交基函数的功率电平是独立可调的。 励磁信号可以被稀疏地采样，或者可以去除激励信号的部分，以便改善组织振动并提供交织超声波振动和检测脉冲。 超声波检测脉冲被施加到至少一个运动检测点，从该运动检测点接收回波信号。 从所接收的回波信号中，确定运动信号，从而计算被摄体的机械性质。

    Method for Shear Wave Ultrasound Vibrometry with Interleaved Push and Detection Pulses
    9.
    发明申请
    Method for Shear Wave Ultrasound Vibrometry with Interleaved Push and Detection Pulses 有权
    具有交错推送和检测脉冲的剪切波超声波振动测量方法

    公开(公告)号：US20110263978A1

    公开(公告)日：2011-10-27

    申请号：US13092574

    申请日：2011-04-22

    申请人： Shigao Chen ,  James F. Greenleaf

    发明人： Shigao Chen ,  James F. Greenleaf

    IPC分类号： A61B8/00

    CPC分类号： A61B8/48 ,  A61B8/485 ,  G01S7/52022 ,  G01S7/52042

    摘要： A shear wave dispersion ultrasound vibrometry (“SDUV”) method for measuring a mechanical property of a subject is provided. Particularly, a set of ultrasonic vibration tone bursts is applied to a vibration origin in the subject so that harmonic vibratory motion is imparted to a tissue of interest. The set of vibration tone bursts effectively act like a single vibration pulse that imparts vibratory motion at larger amplitudes than achievable with a single pulse. Multiple ultrasonic detection pulses are then applied to two or more locations in the tissue of interest in order to measure shear waves propagating outward from the vibration origin. From these measurements, phase or amplitude information related to the shear wave propagation is determined and used to calculate a shear wave speed. Using the shear wave speed information, mechanical properties of the tissue are calculated.

    摘要翻译： 提供了用于测量受试者的机械性质的剪切波分散超声波振动测定（“SDUV”）方法。 特别地，将一组超声波振动音脉冲施加到被摄体中的振动起点，使得谐波振动运动被赋予感兴趣的组织。 这组振动音脉冲有效地像单一的振动脉冲一样，其振幅运动的幅度大于单脉冲可实现的振幅。 然后将多个超声波检测脉冲施加到感兴趣的组织中的两个或更多个位置，以便测量从振动源向外传播的剪切波。 从这些测量中，确定与剪切波传播相关的相位或振幅信息，并用于计算剪切波速度。 使用剪切波速度信息，计算组织的机械性能。

    Vibration generation and detection in shear wave dispersion ultrasound vibrometry with large background motions
    10.
    发明授权
    Vibration generation and detection in shear wave dispersion ultrasound vibrometry with large background motions 有权
    具有大背景运动的剪切波分散超声波振动的振动产生和检测

    公开(公告)号：US08659975B2

    公开(公告)日：2014-02-25

    申请号：US12992228

    申请日：2009-05-15

    申请人： James F. Greenleaf ,  Shigao Chen ,  Yi Zheng ,  Aiping Yao

    发明人： James F. Greenleaf ,  Shigao Chen ,  Yi Zheng ,  Aiping Yao

    IPC分类号： G01S15/00

    CPC分类号： A61B8/485 ,  G01S7/52038

    摘要： A method for measuring a mechanical property of a subject includes using an ultrasonic transducer to apply ultrasonic vibration pulses to a vibration origin in the subject in an on-off time sequence in order to impart a harmonic motion at a prescribed frequency to the subject, and when the vibration pulses are off, preferably using the same transducer to apply ultrasonic detection pulses to a motion detection point and to receive echo signals therefrom in order to sense the harmonic motion on the subject at the motion detection point The ultrasonic detection pulses are interspersed with the vibration pulses and can be applied in a non-uniform manner From the received ultrasonic echo signals, a harmonic signal is detected and a characteristic such as amplitude or phase of the detected harmonic signal is calculated using a Kalman filter or interpolation.

    摘要翻译： 用于测量受试者的机械性质的方法包括使用超声波换能器以开关时间顺序将超声波振动脉冲施加到被检体中的振动起点，以向受检者施加规定频率的谐波运动，以及 当振动脉冲关闭时，优选地使用相同的换能器将超声波检测脉冲施加到运动检测点并从其接收回波信号，以便感测在运动检测点处的对象上的谐波运动。超声波检测脉冲分布在 可以以不均匀的方式施加振动脉冲从接收到的超声波回波信号中，检测出谐波信号，并且使用卡尔曼滤波器或内插来计算检测到的谐波信号的振幅或相位的特性。