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公开(公告)号：US20120238602A1
公开(公告)日：2012-09-20
申请号：US13478163
申请日：2012-05-23
IPC分类号： C07D401/06 , A61K31/4545 , A61K31/454
CPC分类号： C07D401/06 , C07D211/96
摘要： The present invention relates to piperidine sulphonamide derivatives of formula wherein Ar1, Ar2, R1, R2, m and n are as defined in the description and claims, or pharmaceutically suitable acid addition salts thereof. The compounds of formula I are orexin receptor antagonists and the related compounds can be useful in the treatment of sleep apnea, narcolepsy, insomnia, parasomnia, jet lag syndrome, circadian rhythms disorder or sleep disorders associated with neurological diseases.
摘要翻译： 本发明涉及下式的哌啶磺酰胺衍生物其中Ar 1，Ar 2，R 1，R 2，m和n如说明书和权利要求中所定义，或其药学上合适的酸加成盐。 式I化合物是食欲蛋白受体拮抗剂，相关化合物可用于治疗睡眠呼吸暂停，发作性睡病，失眠，睡眠，夜间综合征，昼夜节律障碍或与神经疾病相关的睡眠障碍。
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公开(公告)号：US08133909B2
公开(公告)日：2012-03-13
申请号：US12481627
申请日：2009-06-10
IPC分类号： A61K31/44 , C07D213/02
CPC分类号： C07D213/40 , C07D213/56 , C07D213/75 , C07D215/38 , C07D231/40 , C07D261/08 , C07D277/46 , C07D333/20 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention is concerned with novel sulfonamides of formula wherein R1, R2, R3, R4, R5, Ar, Ar1, Ar2, n, o and p are as described in the description and claims. The compounds are orexin receptor antagonists that may be useful in the treatment of disorders, in which orexin pathways are involved.
摘要翻译： 本发明涉及下列新型磺酰胺，其中R1，R2，R3，R4，R5，Ar，Ar1，Ar2，n，o和p如说明书和权利要求中所述。 这些化合物是食欲素受体拮抗剂，其可用于治疗其中涉及食欲素途径的病症。
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公开(公告)号：US07923470B2
公开(公告)日：2011-04-12
申请号：US12506302
申请日：2009-07-21
IPC分类号： A61K31/39
CPC分类号： C07D413/12 , C07D403/12 , C07D413/14 , C07D417/12
摘要： The present invention is concerned with novel sulfonamides of formula I wherein R1, R2, Ar, Hetaryl, m and n are as described in the description and claims. The compounds are orexin receptor antagonists, useful in the treatment of disorders, in which orexin pathways are involved.
摘要翻译： 本发明涉及式I的新型磺酰胺，其中R 1，R 2，Ar，杂芳基，m和n如说明书和权利要求中所述。 这些化合物是食欲素受体拮抗剂，可用于治疗食欲素途径参与的疾病。
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公开(公告)号：US20110071154A1
公开(公告)日：2011-03-24
申请号：US12958440
申请日：2010-12-02
IPC分类号： A61K31/498 , C07D413/12 , A61K31/423 , C07D417/12 , A61K31/428 , C07D417/14 , C07D413/14 , C07D403/12 , A61P25/00 , A61P25/28 , A61P25/16 , A61P25/22 , A61P25/24 , A61P1/00
CPC分类号： C07D413/12 , C07D403/12 , C07D413/14 , C07D417/12
摘要： The present invention is concerned with novel sulfonamides of formula I wherein R1, R2, Ar, Hetaryl, m and n are as described in the description and claims. The compounds are orexin receptor antagonists, useful in the treatment of disorders, in which orexin pathways are involved.
摘要翻译： 本发明涉及式I的新型磺酰胺，其中R 1，R 2，Ar，杂芳基，m和n如说明书和权利要求中所述。 这些化合物是食欲素受体拮抗剂，可用于治疗食欲素途径参与的病症。
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公开(公告)号：US20090203736A1
公开(公告)日：2009-08-13
申请号：US12365911
申请日：2009-02-05
IPC分类号： A61K31/454 , C07D401/06 , A61P25/00 , A61K31/4545
CPC分类号： C07D401/06 , C07D211/96
摘要： The present invention relates to piperidine sulphonamide derivatives of formula wherein Ar1, Ar2, R1, R2, m and n are as defined in the description and claims, or pharmaceutically suitable acid addition salts thereof. The compounds of formula I are orexin receptor antagonists and the related compounds can be useful in the treatment of sleep apnea, narcolepsy, insomnia, parasomnia, jet lag syndrome, circadian rhythms disorder or sleep disorders associated with neurological diseases.
摘要翻译： 本发明涉及下式的哌啶磺酰胺衍生物其中Ar 1，Ar 2，R 1，R 2，m和n如说明书和权利要求中所定义，或其药学上合适的酸加成盐。 式I化合物是食欲蛋白受体拮抗剂，相关化合物可用于治疗睡眠呼吸暂停，发作性睡病，失眠，睡眠，夜间综合征，昼夜节律障碍或与神经疾病相关的睡眠障碍。
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公开(公告)号：US07534788B2
公开(公告)日：2009-05-19
申请号：US12173888
申请日：2008-07-16
申请人： Peter Mohr , Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Tadakatsu Takahashi , Sven Taylor
发明人： Peter Mohr , Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Tadakatsu Takahashi , Sven Taylor
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4545 , C07D405/06 , C07D409/06
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of formula I wherein X, A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中X，A和R 1至R 4如说明书和权利要求书中所定义，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US07507736B2
公开(公告)日：2009-03-24
申请号：US12019682
申请日：2008-01-25
IPC分类号： A61K31/454 , A61K31/496 , C07D401/12 , C07D451/06
CPC分类号： C07D401/12 , C07D401/02 , C07D401/14 , C07D451/06
摘要： The present invention relates to compounds of formula I wherein A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中A和R 1至R 4如说明书和权利要求书中所定义，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US07388095B2
公开(公告)日：2008-06-17
申请号：US11604563
申请日：2006-11-27
IPC分类号： C07D417/14 , C07D413/14 , C07D401/14
CPC分类号： C07D401/12 , C07D451/06
摘要： The present invention relates to compounds of formula I wherein R1 to R4 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中R 1至R 4和G如说明书和权利要求及其药学上可接受的盐所定义。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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![Pyrrolo [2,3-b] pyridine derivatives](/abs-image/US/2008/04/01/US07351708B2/abs.jpg.150x150.jpg)
公开(公告)号：US07351708B2
公开(公告)日：2008-04-01
申请号：US11634563
申请日：2006-12-06
申请人： Matthias Nettekoven , Olivier Roche
发明人： Matthias Nettekoven , Olivier Roche
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/55 , C07D487/04
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula I wherein R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中R 1至R 4如在说明书和权利要求书中所定义，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US20060160855A1
公开(公告)日：2006-07-20
申请号：US11332955
申请日：2006-01-17
IPC分类号： A61K31/454 , C07D403/02 , A61K31/405
CPC分类号： C07D401/14 , C07D401/12
摘要： The present invention relates to compounds of formula I wherein R1, R2, R3, R4 and m are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to pharmaceutical compositions comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式Ⅰ化合物，其中R 1，R 2，R 3，R 4和R 4， m如说明书和权利要求书中所定义，以及其药学上可接受的盐以及包含这些化合物的药物组合物及其制备方法。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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