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1.发明申请Substituted 4-Amino-Quinazoline Compounds with Metabotropic Glutamate Receptor Regulating Activity and Uses Thereof 审中-公开取代的4-氨基 - 喹唑啉化合物与代谢型谷氨酸受体调节活性及其用途公开(公告)号：US20090069320A1
公开(公告)日：2009-03-12
申请号：US12210365
申请日：2008-09-15
IPC分类号： A61K31/5377 , C07D239/72 , A61K31/517 , A61P29/00 , A61P11/00 , A61P25/00 , C07D413/02
CPC分类号： C07D239/94 , C07D401/12 , C07D403/10 , C07D413/04 , C07D413/10 , C07D417/10
摘要： Substituted 4-amino-quinazoline compounds corresponding to formula I methods for their production, pharmaceutical compositions containing these compounds as active agents, and the uses thereof for treating or inhibiting disorders or disease states.
摘要翻译： 对应于式I生产方法的取代的4-氨基 - 喹唑啉化合物，含有这些化合物作为活性剂的药物组合物及其用于治疗或抑制病症或疾病状态的用途。
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公开(公告)号：US07420056B2
公开(公告)日：2008-09-02
申请号：US11685953
申请日：2007-03-14
申请人： Sven Kuehnert , Stefan Oberboersch , Corinna Sundermann , Michael Haurand , Ruth Jostock , Klaus Schiene , Thomas Tzschentke , Thomas Christoph , Dagmar Kaulartz , Saskia Zemolka
发明人： Sven Kuehnert , Stefan Oberboersch , Corinna Sundermann , Michael Haurand , Ruth Jostock , Klaus Schiene , Thomas Tzschentke , Thomas Christoph , Dagmar Kaulartz , Saskia Zemolka
IPC分类号： C07D487/00 , A01N43/90 , A61K31/519
CPC分类号： C07D471/04
摘要： Substituted bicyclic imidazo-3-yl-amine compounds are provided, as well as processes for the production thereof and pharmaceutical formulations containing these compounds. The use of these compounds for the production of pharmaceutical formulations and related methods of treatment are also provided.
摘要翻译： 提供了取代的双环咪唑-3-基 - 胺化合物，以及其制备方法和含有这些化合物的药物制剂。 还提供了这些化合物用于制备药物制剂和相关治疗方法的用途。
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3.发明授权公开(公告)号：US07300939B2
公开(公告)日：2007-11-27
申请号：US11649156
申请日：2007-01-04
IPC分类号： C07D417/04 , A61K31/496
CPC分类号： C07D417/12 , C07D277/42
摘要： Substituted 1-propiolylpiperazine compounds corresponding to formula I in which X denotes N or C—R2, and n is an integer from 0 to 8, a method for producing such substituted 1-propiolylpiperazine compounds, pharmaceutical compositions containing such substituted 1-propiolylpiperazine compounds, and the use of such substituted 1-propiolylpiperazine compounds for modulating mGluR5 receptor activity or for treating or inhibiting pain and various other conditions, especially conditions at least partly mediated by the mGluR5 receptor.
摘要翻译： 对应于其中X表示N或CR 2的式I的取代的1-丙酰基哌嗪化合物，n为0至8的整数，这种取代的1-丙酰基哌嗪化合物的制备方法，含有这些取代的1-丙酰基哌嗪化合物的药物组合物 取代的1-丙酰基哌嗪化合物，以及这些取代的1-丙酰基哌嗪化合物用于调节mGluR5受体活性或用于治疗或抑制疼痛和各种其它病症，特别是至少部分由mGluR5受体介导的病症。
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4.发明授权Sutstituted tetrahydropyrrolopyrazine compounds and the use thereof in the treatment and/or inhibition of pain 失效取代的四氢吡咯并吡嗪化合物及其在治疗和/或抑制疼痛中的用途公开(公告)号：US07625900B2
公开(公告)日：2009-12-01
申请号：US11873574
申请日：2007-10-17
申请人： Beatrix Merla , Thomas Christoph , Stefan Oberboersch , Klaus Schiene , Gregor Bahrenberg , Robert Frank , Sven Kuehnert , Wolfgang Schroeder
发明人： Beatrix Merla , Thomas Christoph , Stefan Oberboersch , Klaus Schiene , Gregor Bahrenberg , Robert Frank , Sven Kuehnert , Wolfgang Schroeder
IPC分类号： A61K31/495
CPC分类号： C07D487/04
摘要： Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I: processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these compounds for the treatment and/or inhibition of pain and other disorders or disease states at least partly mediated by KCNQ2/3 K+ channels.
摘要翻译： 对应于式I的取代的四氢吡咯并吡嗪化合物：其制备方法，包含这些化合物的药物组合物以及这些化合物用于治疗和/或抑制至少部分由KCNQ2 / 3K +通道介导的疼痛和其它疾病或疾病状态的用途 。
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5.发明授权Substituted tetrahydropyrrolopyrazine compounds and the use thereof in pharmaceutical compositions 失效取代的四氢吡咯并吡嗪化合物及其在药物组合物中的用途公开(公告)号：US07879858B2
公开(公告)日：2011-02-01
申请号：US12425873
申请日：2009-04-17
申请人： Beatrix Merla , Thomas Christoph , Stefan Oberboersch , Klaus Schiene , Gregor Bahrenberg , Robert Frank , Sven Kuehnert , Wolfgang Schroeder
发明人： Beatrix Merla , Thomas Christoph , Stefan Oberboersch , Klaus Schiene , Gregor Bahrenberg , Robert Frank , Sven Kuehnert , Wolfgang Schroeder
IPC分类号： A61K31/495
CPC分类号： C07D487/04
摘要： Substituted tetrahydropyrrolopyrazine compounds corresponding to formula I a process for producing such compounds; and a method of using such compounds to treat or inhibit various disorders or disease states including pain, depression and anxiety.
摘要翻译： 对应于式I的取代的四氢吡咯并吡嗪化合物是制备这些化合物的方法; 以及使用这些化合物治疗或抑制各种疾病或疾病状态（包括疼痛，抑郁和焦虑）的方法。
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6.发明申请Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in Pharmaceutical Compositions 失效取代的四氢吡咯并吡嗪化合物及其在药物组合物中的应用公开(公告)号：US20090258880A1
公开(公告)日：2009-10-15
申请号：US12425873
申请日：2009-04-17
申请人： Beatrix MERLA , Thomas Christoph , Stefan Oberboersch , Klaus Schiene , Gregor Bahrenberg , Robert Frank , Sven Kuehnert , Wolfgang Schroeder
发明人： Beatrix MERLA , Thomas Christoph , Stefan Oberboersch , Klaus Schiene , Gregor Bahrenberg , Robert Frank , Sven Kuehnert , Wolfgang Schroeder
IPC分类号： A61K31/4985 , C07D489/04 , A61P25/00
CPC分类号： C07D487/04
摘要： Substituted tetrahydropyrrolopyrazine compounds corresponding to formula I a process for producing such compounds; and a method of using such compounds to treat or inhibit various disorders or disease states including pain, depression and anxiety.
摘要翻译： 对应于式I的取代的四氢吡咯并吡嗪化合物是制备这些化合物的方法; 以及使用这些化合物治疗或抑制各种疾病或疾病状态（包括疼痛，抑郁和焦虑）的方法。
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7.发明授权Substituted tetrahydropyrrolopyrazine compounds and the use thereof in the treatment and/or inhibition of pain 失效取代的四氢吡咯并吡嗪化合物及其在治疗和/或抑制疼痛中的用途公开(公告)号：US08017772B2
公开(公告)日：2011-09-13
申请号：US12558008
申请日：2009-09-11
申请人： Beatrix Merla , Thomas Christoph , Stefan Oberboersch , Klaus Schiene , Gregor Bahrenberg , Robert Frank , Sven Kuehnert , Wolfgang Schroeder
发明人： Beatrix Merla , Thomas Christoph , Stefan Oberboersch , Klaus Schiene , Gregor Bahrenberg , Robert Frank , Sven Kuehnert , Wolfgang Schroeder
IPC分类号： C07D471/00
CPC分类号： C07D487/04
摘要： Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I: processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these compounds for the treatment and/or inhibition of pain and other disorders or disease states at least partly mediated by KCNQ2/3 K+ channels.
摘要翻译： 对应于式I的取代的四氢吡咯并吡嗪化合物：其制备方法，包含这些化合物的药物组合物以及这些化合物用于治疗和/或抑制至少部分由KCNQ2 / 3K +通道介导的疼痛和其它疾病或疾病状态的用途 。
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8.发明申请Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in the Treatment and/or Inhibition of Pain 失效取代的四氢吡咯并吡嗪化合物及其用途在疼痛的治疗和/或抑制中公开(公告)号：US20080167315A1
公开(公告)日：2008-07-10
申请号：US11873574
申请日：2007-10-17
申请人： Beatrix Merla , Thomas Christoph , Stefan Oberboersch , Klaus Schiene , Gregor Bahrenberg , Robert Frank , Sven Kuehnert , Wolfgang Schroeder
发明人： Beatrix Merla , Thomas Christoph , Stefan Oberboersch , Klaus Schiene , Gregor Bahrenberg , Robert Frank , Sven Kuehnert , Wolfgang Schroeder
IPC分类号： A61K31/4985 , C07D487/04 , A61P29/00
CPC分类号： C07D487/04
摘要： Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I: processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these compounds for the treatment and/or inhibition of pain and other disorders or disease states at least partly mediated by KCNQ2/3 K+ channels.
摘要翻译： 对应于式I的取代的四氢吡咯并吡嗪化合物：其制备方法，包含这些化合物的药物组合物以及这些化合物用于治疗和/或抑制至少部分由KCNQ2 / 3K介导的疼痛和其他疾病或疾病状态的用途， SUP> + 频道。
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公开(公告)号：US08318769B2
公开(公告)日：2012-11-27
申请号：US12420488
申请日：2009-04-08
申请人： Stefan Oberboersch , Melanie Reich , Stefan Schunk , Michael Franz-Martin Engels , Ruth Jostock , Tieno Germann , Jean De Vry , Klaus Schiene , Sabine Hees
发明人： Stefan Oberboersch , Melanie Reich , Stefan Schunk , Michael Franz-Martin Engels , Ruth Jostock , Tieno Germann , Jean De Vry , Klaus Schiene , Sabine Hees
IPC分类号： C07D215/58 , C07D401/14 , C07D213/30 , C07D401/12 , C07D265/36 , A61K31/4709 , A61K31/4465 , A61K31/497 , A61K31/55 , A61K31/45 , A61K31/536 , A61P29/00 , A61P37/08 , A61P27/14 , A61P25/28 , A61P17/00 , A61P17/06 , A61P31/04
CPC分类号： C07D401/14
摘要： Substituted sulfonamide compounds corresponding to formula I: processes for the preparation thereof, pharmaceutical compositions containing these compounds, and the use of such substituted sulfonamide compounds in pharmaceutical compositions for the treatment and/or inhibition of pain and other conditions at least partly mediated by the bradykinin 1 receptor.
摘要翻译： 对应于式I的取代的磺酰胺化合物：其制备方法，含有这些化合物的药物组合物，以及这些取代的磺酰胺化合物在药物组合物中用于治疗和/或抑制至少部分缓激肽介导的疼痛和其它病症的用途 1受体。
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公开(公告)号：US20090298812A1
公开(公告)日：2009-12-03
申请号：US12397771
申请日：2009-03-04
申请人： Stefan Oberboersch , Ruth Jostock , Klaus Schiene , Jean De Vry , Tieno Germann , Sabine Hees , Stefan Schunk , Melanie Reich
发明人： Stefan Oberboersch , Ruth Jostock , Klaus Schiene , Jean De Vry , Tieno Germann , Sabine Hees , Stefan Schunk , Melanie Reich
IPC分类号： A61K31/55 , C07D401/14 , A61K31/497 , C07D401/02
CPC分类号： C07D401/12 , C07D211/58 , C07D401/14
摘要： Substituted sulfonamide compounds corresponding to the formula I processes for the preparation thereof, pharmaceutical compositions containing these compounds and the use of substituted sulfonamide compounds for the preparation of pharmaceutical compositions for treating pain and other conditions at least partly mediated via the bradykinin 1 receptor.
摘要翻译： 对应于式I的取代磺酰胺化合物的制备方法，含有这些化合物的药物组合物和使用取代的磺酰胺化合物制备用于治疗至少部分通过缓激肽1受体介导的疼痛和其它病症的药物组合物。
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