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公开(公告)号:US10081617B2
公开(公告)日:2018-09-25
申请号:US15565748
申请日:2016-04-11
发明人: Eric Mertz , Scott D. Edmondson , Sung-Sau So , Wanying Sun , Weiguo Liu , Santhosh F. Neelamkavil , Ying-Duo Gao , Alan Hruza , Yi Zang , Amjad Ali , Rudrajit Mal , Jiafang He , Rongze Kuang , Heping Wu , Anthony K. Ogawa , Andrew F. Nolting
IPC分类号: C07D401/14 , C07D413/14 , C07D409/14
摘要: The present invention provides a compound of Formula (I); and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号:US09868727B2
公开(公告)日:2018-01-16
申请号:US15329634
申请日:2015-07-23
发明人: Weiguo Liu , Scott D. Edmondson , Zhuyan Guo , Sung-Sau So , Anthony K. Ogawa , Rongze Kuang , Heping Wu , Amjad Ali , Ying-Duo Gao , Yu Jiang , Chunsing Li , Tingting Yu
IPC分类号: C07D409/14 , C07D417/14 , C07D413/14 , C07D401/14 , C07D401/06 , A61K31/4439 , A61K31/444
CPC分类号: C07D409/14 , A61P7/02 , C07D401/06 , C07D401/14 , C07D413/14 , C07D417/14
摘要: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号:US09783530B2
公开(公告)日:2017-10-10
申请号:US15312839
申请日:2015-05-22
发明人: Weiguo Liu , Scott D. Edmondson , Zhuyan Guo , Eric Mertz , Anthony K. Ogawa , Sung-Sau So , Wanying Sun , Linda L. Brockunier , Amjad Ali , Rongze Kuang , Heping Wu
IPC分类号: C07D417/10 , C07D401/10 , C07D213/89 , C07D401/12 , C07D401/14 , C07D413/10
CPC分类号: C07D417/10 , C07D213/89 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/10
摘要: The present invention provides a compound of Formula I (The chemical formula should be inserted here.) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号:US20220235033A1
公开(公告)日:2022-07-28
申请号:US17613988
申请日:2020-05-26
发明人: Jacqueline D. Hicks , John S. Debenham , Amjad Ali , Lan Wei , Tianying Jian , Dexi Yang , Anthony K. Ogawa , Wenlang Fu , Matthew Lombardo , Rongze Kuang , Meng Yang , Sung-Sau So , Kenneth Ellsworth , Peter Nizner , Daniel A. Tatosian , Robert R. Wilkening , Jun Wang
IPC分类号: C07D401/14 , C07D405/14 , C07D471/04 , C07D413/14 , C07D417/14
摘要: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XI activation inhibitors.
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公开(公告)号:US20160347757A1
公开(公告)日:2016-12-01
申请号:US15116659
申请日:2015-02-06
申请人: Santhosh F. NEELAMKAVIL , Scott D. EDMONDSON , Zhuyan GUO , Alan W. HRUZA , Zahid HUSSAIN , Charles A. LESBURG , Remond MONINGKA , Anthony K. OGAWA , Rudrajit MAL , MERCK SHARP & DOHME CORP
发明人: Santhosh F. Neelamkavil , Scott D. Edmondson , Zhuyan Guo , Alan W. Hruza , Zahid Hussain , Charles A. Lesburg , Remond Moningka , Anthony K. Ogawa , Rudrajit Mal
IPC分类号: C07D487/08 , C07D471/08
CPC分类号: C07D487/08 , C07D471/08
摘要: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
摘要翻译: 本发明提供式(I)的化合物和包含一种或多种所述化合物的药物组合物,以及使用所述化合物治疗或预防血栓形成,栓塞,高凝状态或纤维变化的方法。 该化合物是选择性因子XIa抑制剂或因子XIa和血浆激肽释放酶的双重抑制剂。
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公开(公告)号:US20180370947A1
公开(公告)日:2018-12-27
申请号:US15780134
申请日:2016-11-29
IPC分类号: C07D401/10 , A61P7/02 , C07D401/14 , C07D409/14
摘要: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号:US20180079743A1
公开(公告)日:2018-03-22
申请号:US15565748
申请日:2016-04-11
发明人: Eric Mertz , Scott D. Edmondson , Sung-Sau So , Wanying Sun , Weiguo Liu , Santhosh F. Neelamkavil , Ying-Duo Gao , Alan Hruza , Yi Zang , Amjad Ali , Rudrajit Mal , Jiafang He , Rongze Kuang , Heping Wu , Anthony K. Ogawa , Andrew F. Nolting
IPC分类号: C07D401/14 , C07D409/14 , C07D413/14
CPC分类号: C07D401/14 , C07D409/14 , C07D413/14
摘要: The present invention provides a compound of Formula (I); and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号:US09663527B2
公开(公告)日:2017-05-30
申请号:US15116659
申请日:2015-02-06
发明人: Santhosh F. Neelamkavil , Scott D. Edmondson , Zhuyan Guo , Alan W. Hruza , Zahid Hussain , Charles A. Lesburg , Remond Moningka , Anthony K. Ogawa , Rudrajit Mal
IPC分类号: C07D487/08 , C07D471/08
CPC分类号: C07D487/08 , C07D471/08
摘要: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号:US10472344B2
公开(公告)日:2019-11-12
申请号:US15780134
申请日:2016-11-29
IPC分类号: C07D401/10 , C07D401/14 , C07D409/14 , A61P7/02
摘要: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号:US20170210732A1
公开(公告)日:2017-07-27
申请号:US15329634
申请日:2015-07-23
发明人: Weiguo Liu , Scott D. Edmondson , Zhuyan Guo , Sung-Sau So , Anthony K. Ogawa , Rongze Kuang , Heping Wu , Amjad Ali , Ying-Duo Gao , Yu Jiang , Chunsing Li , Tingting Yu
IPC分类号: C07D409/14 , C07D401/06 , C07D401/14 , C07D417/14 , C07D413/14
CPC分类号: C07D409/14 , A61P7/02 , C07D401/06 , C07D401/14 , C07D413/14 , C07D417/14
摘要: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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