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公开(公告)号:US20160297794A1
公开(公告)日:2016-10-13
申请号:US15100940
申请日:2014-12-02
发明人: Yang Cao , Donald R. Gauthier, Jr. , Guy R. Humphrey , Tetsuji Itoh , Michel Journet , Gang Qian , Benjamin D. Sherry , David M. Tschaen
IPC分类号: C07D401/06 , C07D213/69
CPC分类号: C07D401/06 , C07D213/69 , C07D213/78
摘要: The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting reverse transcriptase and HIV replication, and the treatment of human immunodeficiency virus infection in humans.
摘要翻译: 本发明涉及一种合成3-(取代的苯氧基)-1 - [(5-氧代-4,5-二氢-1H-1,2,4-三唑-3-基)甲基]] - 吡啶-2(1H) - 酮衍生物。 通过本发明的方法合成的化合物是用于抑制逆转录酶和HIV复制的HIV逆转录酶抑制剂以及人类免疫缺陷病毒感染的治疗。
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公开(公告)号:US09663490B2
公开(公告)日:2017-05-30
申请号:US14649837
申请日:2013-12-04
发明人: Tetsuji Itoh , Ingyu Jeon , Ian Mangion , Gang Qian , Benjamin D. Sherry , Donald R. Gauthier , Yang Cao
IPC分类号: C07D401/06
CPC分类号: C07D401/06
摘要: The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting reverse transcriptase, HIV replication and the treatment of human immunodeficiency virus infection in humans.
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公开(公告)号:US10167298B2
公开(公告)日:2019-01-01
申请号:US15032663
申请日:2014-10-24
发明人: Michael McNevin , Yong Liu , Ian Mangion , Alfred Lee , Joyce Stellabott , Benjamin D. Sherry , Gary Martin , Kung-I Feng , Scott Schultz , Ryan Cohen , Yanfeng Zhang
IPC分类号: A61K31/5365 , C07D498/04 , A61P1/16 , A61K45/06
摘要: The present invention relates to novel Pseudopolymorphs of Compound A, compositions comprising at least one Pseudopolymorph of Compound A, and methods of using the Pseudopolymorphs of Compound A for preparing compositions useful for treating or preventing HCV infection in a patient, wherein Compound A has the structure.
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公开(公告)号:US09598397B2
公开(公告)日:2017-03-21
申请号:US15100940
申请日:2014-12-02
发明人: Yang Cao , Donald R. Gauthier, Jr. , Guy R. Humphrey , Tetsuji Itoh , Michel Journet , Gang Qian , Benjamin D. Sherry , David M. Tschaen
IPC分类号: C07D401/06 , C07D213/69 , C07D213/78
CPC分类号: C07D401/06 , C07D213/69 , C07D213/78
摘要: The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting reverse transcriptase and HIV replication, and the treatment of human immunodeficiency virus infection in humans.
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公开(公告)号:US20150329521A1
公开(公告)日:2015-11-19
申请号:US14649837
申请日:2013-12-04
申请人: Tetsuji ITOH , Ingyu JEON , Ian MANGION , Gang QIAN , Benjamin D. SHERRY , Donald R. GAUTHIER , Yang CAO , MERCK SHARP & DOHME CORP.
发明人: Tetsuji Itoh , Ingyu Jeon , Ian Mangion , Gang QIAN , Benjamin D. Sherry , Donald R. Gauthier , Yang CAO
IPC分类号: C07D401/06
CPC分类号: C07D401/06
摘要: The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting reverse transcriptase, HIV replication and the treatment of human immunodeficiency virus infection in humans.
摘要翻译: 本发明涉及一种合成3-(取代的苯氧基)-1 - [(5-氧代-4,5-二氢-1H-1,2,4-三唑-3-基)甲基]] - 吡啶-2(1H) - 酮衍生物。 通过本发明的方法合成的化合物是可用于抑制逆转录酶,HIV复制和人类免疫缺陷病毒感染治疗的HIV逆转录酶抑制剂。
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