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公开(公告)号:US09181261B2
公开(公告)日:2015-11-10
申请号:US14401941
申请日:2013-05-17
发明人: Shawn J. Stachel , Melissa Egbertson , Edward Brnardic , Kristen G. Jones , John M. Sanders , Darrell Henze
IPC分类号: C07D487/04 , C07D417/10 , C07D471/04 , C07D277/28 , C07D277/66 , C07D239/34 , C07D239/42 , C07D277/30 , C07D403/04 , C07D417/12
CPC分类号: C07D487/04 , C07D239/34 , C07D239/42 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/66 , C07D403/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要: The present invention is directed to benzyl urea compounds, which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence may be useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor Trk-A, Trk-B and/or Trk-C.
摘要翻译: 本发明涉及苄基脲化合物,其是原肌球蛋白相关激酶(Trk)家族蛋白激酶抑制剂,因此可用于治疗疼痛,炎症,癌症,再狭窄,动脉粥样硬化,牛皮癣,血栓形成,疾病, 与神经生长因子(NGF)受体Trk-A,Trk-B和/或Trk-C的异常活动相关的疾病或障碍或与脱髓鞘或脱髓鞘相关的疾病,损伤或功能障碍。
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公开(公告)号:US20150141428A1
公开(公告)日:2015-05-21
申请号:US14401941
申请日:2013-05-17
发明人: Shawn J. Stachel , Melissa Egbertson , Edward Brnardic , Kristen G. Jones , John M. Sanders , Darrell Henze
IPC分类号: C07D487/04 , C07D277/30 , C07D403/04 , C07D239/34 , C07D239/42 , C07D471/04 , C07D417/12
CPC分类号: C07D487/04 , C07D239/34 , C07D239/42 , C07D277/28 , C07D277/30 , C07D277/32 , C07D277/66 , C07D403/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要: The present invention is directed to benzyl urea compounds, which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence may be useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor Trk-A, Trk-B and/or Trk-C.
摘要翻译: 本发明涉及苄基脲化合物,其是原肌球蛋白相关激酶(Trk)家族蛋白激酶抑制剂,因此可用于治疗疼痛,炎症,癌症,再狭窄,动脉粥样硬化,牛皮癣,血栓形成,疾病, 与神经生长因子(NGF)受体Trk-A,Trk-B和/或Trk-C的异常活动相关的疾病或障碍或与脱髓鞘或脱髓鞘相关的疾病,损伤或功能障碍。
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