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公开(公告)号:US09717714B2
公开(公告)日:2017-08-01
申请号:US14653445
申请日:2013-12-17
发明人: Debra Ondeyka , Xiaoxia Qian , Petr Vachal , Sriram Tyagarajan , Cameron J. Smith , Hong Li , Jianming Bao
IPC分类号: A61K31/4439 , A61K31/423 , A61K31/444 , A61K31/506 , A61K31/5377 , C07D413/14 , C07D413/06 , C07D263/52 , A61K45/06
CPC分类号: A61K31/423 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D263/52 , C07D413/06 , C07D413/14
摘要: Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and may be useful for raising HDL-cholesterol and reducing LDL-cholesterol in human patients and for treating or preventing atherosclerosis. The chemical compounds that are disclosed cholesterol ester transfer protein (CETP) and are expected to have utility in raising HDL-C, lowering LDL-C, and in the treatment and prevention of atherosclerosis.
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公开(公告)号:US09353101B2
公开(公告)日:2016-05-31
申请号:US14398165
申请日:2013-04-26
发明人: John J. Acton, III , Feng Ye , Petr Vachal , Deyou Sha , James F. Dropinski , Lin Chu , Debra Ondeyka , Alexander J. Kim , Vincent J. Colandrea , Yi Zang , Fengqi Zhang , Guizhen Dong
IPC分类号: C07D417/14 , C07D413/14 , A61K31/506 , A61K31/5377 , A61K31/444 , A61K45/06
CPC分类号: C07D417/14 , A61K31/444 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/14
摘要: Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and may be useful for raising HDL-cholesterol and reducing LDL-cholesterol in human patients and for treating or preventing atherosclerosis.
摘要翻译: 具有式I结构的化合物,包括化合物的药学上可接受的盐,是CETP抑制剂,可用于提高人类患者的HDL-胆固醇和降低LDL-胆固醇,并用于治疗或预防动脉粥样硬化。
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公开(公告)号:US20150342931A1
公开(公告)日:2015-12-03
申请号:US14653445
申请日:2013-12-17
发明人: Debra Ondeyka , Xiaoxia Qian , Petr Vachal , Sriram Tyagarajan , Cameron J. Smith , Hong Li , Jianming Bao
IPC分类号: A61K31/423 , A61K31/4439 , C07D413/14 , A61K45/06 , A61K31/506 , A61K31/5377 , C07D263/52 , C07D413/06 , A61K31/444
CPC分类号: A61K31/423 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D263/52 , C07D413/06 , C07D413/14
摘要: Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and may be useful for raising HDL-cholesterol and reducing LDL-cholesterol in human patients and for treating or preventing atherosclerosis. The chemical compounds that are disclosed cholesterol ester transfer protein (CETP) and are expected to have utility in raising HDL-C, lowering LDL-C, and in the treatment and prevention of atherosclerosis.
摘要翻译: 具有式(I)结构的化合物,包括化合物的药学上可接受的盐,是CETP抑制剂,可用于提高人类患者的HDL-胆固醇和降低LDL-胆固醇,并用于治疗或预防动脉粥样硬化。 公开了胆固醇酯转移蛋白(CETP)的化合物,并且预期可用于升高HDL-C,降低LDL-C,以及治疗和预防动脉粥样硬化。
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公开(公告)号:US20150111866A1
公开(公告)日:2015-04-23
申请号:US14398165
申请日:2013-04-26
发明人: John J. Acton, III , Feng Ye , Petr Vachal , Deyou Sha , James F. Dropinski , Lin Chu , Debra Ondeyka , Alexander J. Kim , Vincent J. Colandrea , Yi Zang , Fengqi Zhang , Guizhen Dong
IPC分类号: C07D417/14 , A61K45/06 , A61K31/5377 , A61K31/444 , C07D413/14 , A61K31/506
CPC分类号: C07D417/14 , A61K31/444 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/14
摘要: Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and may be useful for raising HDL-cholesterol and reducing LDL-cholesterol in human patients and for treating or preventing atherosclerosis.
摘要翻译: 具有式I结构的化合物,包括化合物的药学上可接受的盐,是CETP抑制剂,可用于提高人类患者的HDL-胆固醇和降低LDL-胆固醇,并用于治疗或预防动脉粥样硬化。
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