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公开(公告)号：US10815214B2
公开(公告)日：2020-10-27
申请号：US16576133
申请日：2019-09-19
发明人： Cheol K. Chung , Mark E. Scott , Paul G. Bulger , Kevin M. Belyk , John Limanto , Guy R. Humphrey
IPC分类号： C07D401/10
摘要： A novel process is provided for the efficient preparation of an asymmetric compound of structural formula I: comprising a copper-catalyzed, carbon-nitrogen cross-coupling step. The process described as part of the present invention can be used to manufacture poly (ADP-ribose) polymerase (PARP) inhibitors, which may be useful for the treatment of cancer. In particular, the present invention describes a process for the manufacture of the PARP inhibitor, 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide.
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公开(公告)号：US20200010449A1
公开(公告)日：2020-01-09
申请号：US16576133
申请日：2019-09-19
发明人： Cheol K. Chung , Mark E. Scott , Paul G. Bulger , Kevin M. Belyk , John Limanto , Guy R. Humphrey
IPC分类号： C07D401/10
摘要： A novel process is provided for the efficient preparation of an asymmetric compound of structural formula I: comprising a copper-catalyzed, carbon-nitrogen cross-coupling step. The process described as part of the present invention can be used to manufacture poly (ADP-ribose) polymerase (PARP) inhibitors, which may be useful for the treatment of cancer. In particular, the present invention describes a process for the manufacture of the PARP inhibitor, 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide.
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