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公开(公告)号:US20190352294A1
公开(公告)日:2019-11-21
申请号:US16461849
申请日:2017-11-13
申请人: Ashwin RAO , Brian Alexander MCKITTRICK , Matthew LOMBARDO , Jacqueline D. HICKS , Amy Bittner MCCRACKEN , Hong Dong CHU , Sung-Sau SO , Peter ORTH , Zhicai WU , Ping LAN , John S. DEBENHAM , Brent R. WHITEHEAD , Jerry A. TAYLOR , Zhongxiang SUN , Revathi Reddy KATIPALLY , Jonathan E. GABLE , Markus K. DAHLGREN , Sathesh P. BHAT , Merck Sharp & Dohme Corp.
发明人: Ashwin U. Rao , Brian Alexander McKittrick , Matthew Lombardo , Jacqueline D. Hicks , Amy Bittner McCracken , Hong Dong Chu , Sung-Sau So , Peter Orth , Zhicai Wu , Ping Lan , John S. Debenham , Brent R. Whitehead , Jerry A. Taylor , Zhongxiang Sun , Revathi Reddy Katipally , Jonathan E. Gable , Markus K. Dahlgren , Sathesh P. Bhat
IPC分类号: C07D413/14 , C07D495/04 , A61P7/02
摘要: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIIa inhibitors.
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公开(公告)号:US20170210732A1
公开(公告)日:2017-07-27
申请号:US15329634
申请日:2015-07-23
发明人: Weiguo Liu , Scott D. Edmondson , Zhuyan Guo , Sung-Sau So , Anthony K. Ogawa , Rongze Kuang , Heping Wu , Amjad Ali , Ying-Duo Gao , Yu Jiang , Chunsing Li , Tingting Yu
IPC分类号: C07D409/14 , C07D401/06 , C07D401/14 , C07D417/14 , C07D413/14
CPC分类号: C07D409/14 , A61P7/02 , C07D401/06 , C07D401/14 , C07D413/14 , C07D417/14
摘要: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号:US20170197953A1
公开(公告)日:2017-07-13
申请号:US15312839
申请日:2015-05-22
发明人: Weiguo Liu , Scott D. Edmondson , Zhuyan Guo , Eric Mertz , Anthony K. Ogawa , Sung-Sau So , Wanying Sun , Linda L. Brockunier , Amjad Ali , Rongze Kuang , Heping Wu
IPC分类号: C07D417/10 , C07D413/10 , C07D401/12 , C07D401/14 , C07D401/10 , C07D213/89
CPC分类号: C07D417/10 , C07D213/89 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/10
摘要: The present invention provides a compound of Formula I (The chemical formula should be inserted here.) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号:US10123995B2
公开(公告)日:2018-11-13
申请号:US15542948
申请日:2016-01-15
发明人: Eric Mertz , Weiguo Liu , Scott D. Edmondson , Amjad Ali , Ying-Duo Gao , Santhosh F. Neelamkavil , Sung-Sau So , Remond Moningka , Wanying Sun , Alan Hruza , Linda L. Brockunier
IPC分类号: A61K31/435 , A61K31/4375 , A61K31/195 , A61P7/02 , A61P7/04 , C07D221/18 , C07D221/04 , C07D401/10
摘要: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号:US20180079743A1
公开(公告)日:2018-03-22
申请号:US15565748
申请日:2016-04-11
发明人: Eric Mertz , Scott D. Edmondson , Sung-Sau So , Wanying Sun , Weiguo Liu , Santhosh F. Neelamkavil , Ying-Duo Gao , Alan Hruza , Yi Zang , Amjad Ali , Rudrajit Mal , Jiafang He , Rongze Kuang , Heping Wu , Anthony K. Ogawa , Andrew F. Nolting
IPC分类号: C07D401/14 , C07D409/14 , C07D413/14
CPC分类号: C07D401/14 , C07D409/14 , C07D413/14
摘要: The present invention provides a compound of Formula (I); and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号:US20180000795A1
公开(公告)日:2018-01-04
申请号:US15542948
申请日:2016-01-15
发明人: Eric Mertz , Weiguo Liu , Scott D. Edmondson , Amjad Ali , Ying-Duo Gao , Santhosh F. Neelamkavil , Sung-Sau So , Remond Moningka , Wanying Sun , Alan Hruza , Linda L. Brockunier
IPC分类号: A61K31/435 , A61K31/195 , C07D221/18 , C07D401/10
CPC分类号: A61K31/435 , A61K31/195 , A61K31/4375 , A61P7/02 , A61P7/04 , C07D221/04 , C07D221/18 , C07D401/10
摘要: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号:US20170240523A1
公开(公告)日:2017-08-24
申请号:US15329635
申请日:2015-07-23
发明人: Weiguo Liu , Scott D Edmondson , Zhuyan Guo , Alan Hruza , Sung-Sau So , Wanying Sun , Amjad All , Rongze Kuang , Ying-Duo Gao , Anthony K Ogawa
IPC分类号: C07D401/06 , C07D401/14
CPC分类号: C07D401/06 , C07D401/14
摘要: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoaguability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号:US10081617B2
公开(公告)日:2018-09-25
申请号:US15565748
申请日:2016-04-11
发明人: Eric Mertz , Scott D. Edmondson , Sung-Sau So , Wanying Sun , Weiguo Liu , Santhosh F. Neelamkavil , Ying-Duo Gao , Alan Hruza , Yi Zang , Amjad Ali , Rudrajit Mal , Jiafang He , Rongze Kuang , Heping Wu , Anthony K. Ogawa , Andrew F. Nolting
IPC分类号: C07D401/14 , C07D413/14 , C07D409/14
摘要: The present invention provides a compound of Formula (I); and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号:US09868727B2
公开(公告)日:2018-01-16
申请号:US15329634
申请日:2015-07-23
发明人: Weiguo Liu , Scott D. Edmondson , Zhuyan Guo , Sung-Sau So , Anthony K. Ogawa , Rongze Kuang , Heping Wu , Amjad Ali , Ying-Duo Gao , Yu Jiang , Chunsing Li , Tingting Yu
IPC分类号: C07D409/14 , C07D417/14 , C07D413/14 , C07D401/14 , C07D401/06 , A61K31/4439 , A61K31/444
CPC分类号: C07D409/14 , A61P7/02 , C07D401/06 , C07D401/14 , C07D413/14 , C07D417/14
摘要: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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公开(公告)号:US09783530B2
公开(公告)日:2017-10-10
申请号:US15312839
申请日:2015-05-22
发明人: Weiguo Liu , Scott D. Edmondson , Zhuyan Guo , Eric Mertz , Anthony K. Ogawa , Sung-Sau So , Wanying Sun , Linda L. Brockunier , Amjad Ali , Rongze Kuang , Heping Wu
IPC分类号: C07D417/10 , C07D401/10 , C07D213/89 , C07D401/12 , C07D401/14 , C07D413/10
CPC分类号: C07D417/10 , C07D213/89 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/10
摘要: The present invention provides a compound of Formula I (The chemical formula should be inserted here.) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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