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公开(公告)号:US20100256097A1
公开(公告)日:2010-10-07
申请号:US12665045
申请日:2008-06-16
申请人: Michael Altman , Matthew Christopher , Jonathan B. Grimm , Andrew Haidle , Kaleen Konrad , Jongwon Lim , Rachel N. MacCoss , Michelle Machacek , Ekundayo Osimboni , Ryan D. Otte , Tony Siu , Kerrie Spencer , Brandon Taoka , Paul Tempest , Kevin Wilson , Hyan Chong Woo , Jonathan Young , Anna Zabierek
发明人: Michael Altman , Matthew Christopher , Jonathan B. Grimm , Andrew Haidle , Kaleen Konrad , Jongwon Lim , Rachel N. MacCoss , Michelle Machacek , Ekundayo Osimboni , Ryan D. Otte , Tony Siu , Kerrie Spencer , Brandon Taoka , Paul Tempest , Kevin Wilson , Hyan Chong Woo , Jonathan Young , Anna Zabierek
IPC分类号: A61K31/675 , C07D409/14 , A61K31/4439 , A61K31/4436 , C07D413/14 , A61K31/5377 , C07D409/12 , A61K31/501 , C07F9/28 , C07D417/14 , A61K31/541
CPC分类号: C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D498/10 , C07F9/65586 , C07F9/65685
摘要: The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
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公开(公告)号:US08367706B2
公开(公告)日:2013-02-05
申请号:US12665045
申请日:2008-06-16
申请人: Michael Altman , Matthew Christopher , Jonathan B. Grimm , Andrew Haidle , Kaleen Konrad , Jongwon Lim , Rachel N. MacCoss , Michelle Machacek , Ekundayo Osimboni , Ryan D. Otte , Tony Siu , Kerrie Spencer , Brandon Taoka , Paul Tempest , Kevin Wilson , Hyun Chong Woo , Jonathan Young , Anna Zabierek
发明人: Michael Altman , Matthew Christopher , Jonathan B. Grimm , Andrew Haidle , Kaleen Konrad , Jongwon Lim , Rachel N. MacCoss , Michelle Machacek , Ekundayo Osimboni , Ryan D. Otte , Tony Siu , Kerrie Spencer , Brandon Taoka , Paul Tempest , Kevin Wilson , Hyun Chong Woo , Jonathan Young , Anna Zabierek
IPC分类号: A61K31/4436 , C07D409/12
CPC分类号: C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D498/10 , C07F9/65586 , C07F9/65685
摘要: The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
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公开(公告)号:US20110112081A1
公开(公告)日:2011-05-12
申请号:US13002776
申请日:2009-07-01
申请人: Kevin Wilson , Gabriela de Almeida , Andrew Haidle , Kaleen Konrad , Michelle Machacek , Ann Zabierek
发明人: Kevin Wilson , Gabriela de Almeida , Andrew Haidle , Kaleen Konrad , Michelle Machacek , Ann Zabierek
IPC分类号: A61K31/381 , C07D333/38 , C07D413/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D417/12 , A61K31/5377 , A61K31/4436 , A61K31/4245 , A61K31/496 , A61K31/541 , A61K31/506 , A61K31/4025 , A61K31/4192 , A61P35/00
CPC分类号: C07D333/38 , C07D409/04 , C07D409/12 , C07D413/12
摘要: The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2). The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 and TYK2 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
摘要翻译: 本发明提供抑制四种已知的哺乳动物JAK激酶(JAK1,JAK2,JAK3和TYK2)的化合物。 本发明还提供了包含这种抑制化合物的组合物和通过将该化合物施用于需要治疗骨髓增生性疾病或癌症的患者的JAK1,JAK2,JAK3和TYK2的活性的方法。
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公开(公告)号:US08420695B2
公开(公告)日:2013-04-16
申请号:US13002776
申请日:2009-07-01
申请人: Kevin Wilson , Gabriela de Almeida , Andrew Haidle , Kaleen Konrad , Michelle Machacek , Ann Zabierek
发明人: Kevin Wilson , Gabriela de Almeida , Andrew Haidle , Kaleen Konrad , Michelle Machacek , Ann Zabierek
IPC分类号: A61K31/38 , C07D333/36 , C07D333/42
CPC分类号: C07D333/38 , C07D409/04 , C07D409/12 , C07D413/12
摘要: The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2). The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 and TYK2 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer.
摘要翻译: 本发明提供抑制四种已知的哺乳动物JAK激酶(JAK1,JAK2,JAK3和TYK2)的化合物。 本发明还提供了包含这种抑制化合物的组合物和通过将该化合物施用于需要治疗骨髓增生性疾病或癌症的患者的JAK1,JAK2,JAK3和TYK2的活性的方法。
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