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    Human marco scavenger receptor
    4.
    发明授权
    Human marco scavenger receptor 失效
    人类marco清道夫受体

    公开(公告)号：US5916766A

    公开(公告)日：1999-06-29

    申请号：US794795

    申请日：1997-02-04

    申请人： Nabil Elshourbagy ,  John Adamou ,  Mitchell Gross ,  Paul Lysko

    发明人： Nabil Elshourbagy ,  John Adamou ,  Mitchell Gross ,  Paul Lysko

    IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  C07K14/705 ,  C07K16/28 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12R1/91 ,  G01N33/566 ,  G01N33/68

    CPC分类号： G01N33/6893 ,  C07K14/705 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2799/026 ,  G01N2333/705

    摘要： Human Marco scavenger receptor polypeptides (HMarcoSR) and DNA (RNA) encoding such HMarcoSR and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HMarcoSR for the treatment of various cardivascular disorders, gangrene, and loss of fuunction in the extremeties. Antagonists against such HMarcoSR and their use as a therapeutic to treat various cardivascular disorders, gangrene, and loss of fuunction in the extremeties are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the HMarcoSR and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人类Marco清道夫受体多肽（HMarcoSR）和编码这种HMarcoSR的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种HMarcoSR治疗各种心血管疾病，坏疽和功能丧失的方法。 还公开了针对这种HMarcoSR的拮抗剂及其作为治疗用于治疗各种心血管疾病，坏疽和功能丧失的二恶英的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码HMarcoSR的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。

    Human marco scavenger receptor
    5.
    发明授权
    Human marco scavenger receptor 失效
    人类marco清道夫受体

    公开(公告)号：US06197931B1

    公开(公告)日：2001-03-06

    申请号：US09249200

    申请日：1999-02-12

    申请人： Nabil Elshourbagy ,  John Adamou ,  Mitchell Gross ,  Paul Lysko

    发明人： Nabil Elshourbagy ,  John Adamou ,  Mitchell Gross ,  Paul Lysko

    IPC分类号： C07K14705

    CPC分类号： G01N33/6893 ,  A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C07K2319/00 ,  C12N2799/026 ,  G01N2333/705

    摘要： Human Marco scavenger receptor polypeptides (HMarcoSR) and DNA (RNA) encoding such HMarcoSR and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HMarcoSR for the treatment of various cardivascular disorders, gangrene, and loss of function in the extremeties. Antagonists against such HMarcoSR and their use as a therapeutic to treat of various cardivascular disorders, gangrene, and loss of function in the extremeties are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the HMarcoSR and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人类Marco清道夫受体多肽（HMarcoSR）和编码这种HMarcoSR的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种HMarcoSR治疗各种心血管疾病，坏疽和功能丧失的方法。 还公开了抗HMarcoSR的拮抗剂及其作为治疗各种心血管疾病，坏疽和功能丧失的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码HMarcoSR的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。

    Human monoclonal antibody
    7.
    发明申请
    Human monoclonal antibody 审中-公开
    人单克隆抗体

    公开(公告)号：US20050175986A1

    公开(公告)日：2005-08-11

    申请号：US10461576

    申请日：2003-06-13

    申请人： Mitchell Gross ,  Raymond Sweet ,  Geraldine Taylor

    发明人： Mitchell Gross ,  Raymond Sweet ,  Geraldine Taylor

    IPC分类号： C07H21/04 ,  C07K16/10 ,  C07K16/12 ,  C12N5/06 ,  C12Q1/70

    CPC分类号： C07H21/04 ,  A61K2039/505 ,  C07K16/1027 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/76

    摘要： This invention relates to novel human monoclonal antibodies (mAbs) and to the genes encoding same. More specifically, this invention relates to human monoclonal antibodies specifically reactive with an epitope of the fusion (F) protein of Respiratory Syncytial Virus (RSV). Such antibodies are useful for the therapeutic and/or prophylactic treatment of RSV infection in human patients, particularly infants and young children.

    摘要翻译： 本发明涉及新型人单克隆抗体（mAb）及其相关基因。 更具体地，本发明涉及与呼吸道合胞病毒（RSV）的融合（F）蛋白的表位特异性反应的人单克隆抗体。 这样的抗体可用于治疗和/或预防人类患者，特别是婴儿和幼儿中的RSV感染。