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公开(公告)号:US20100179304A1
公开(公告)日:2010-07-15
申请号:US12587452
申请日:2009-10-07
IPC分类号: C07K1/113 , C07D457/12 , C07D457/06 , C07D457/02
CPC分类号: C07D471/04 , A61K38/00 , C07D471/06 , C07K14/6555
摘要: Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is: 6-n-propyl-8β-ergolinglmethylthioacetyl-D-Phe-c(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH2
摘要翻译: 公开了一系列在体内保持生长抑素和多巴胺活性的生长抑素 - 多巴胺嵌合类似物。 一个例子是:6-正丙基-8β-麦角酰甲基硫代乙酰基-D-Phe-c(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH 2
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公开(公告)号:US08324386B2
公开(公告)日:2012-12-04
申请号:US12587452
申请日:2009-10-07
IPC分类号: C07D457/00
CPC分类号: C07D471/04 , A61K38/00 , C07D471/06 , C07K14/6555
摘要: Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is: 6-n-propyl-8β-ergolinglmethylthioacetyl-D-Phe-c(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH2.
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公开(公告)号:US07579435B2
公开(公告)日:2009-08-25
申请号:US10479771
申请日:2002-06-07
IPC分类号: C07K7/00
CPC分类号: C07D471/04 , A61K38/00 , C07D471/06 , C07K14/6555
摘要: Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is: 6-n-propyl-8β-ergolinglmethylthioacetyl-D-Phe-c-(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH2.
摘要翻译: 公开了一系列在体内保持生长抑素和多巴胺活性的生长抑素 - 多巴胺嵌合类似物。 一个例子是6-正丙基-β-麦角酰甲基硫代乙酰基-D-Phe-c-(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH 2。
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公开(公告)号:US07572883B2
公开(公告)日:2009-08-11
申请号:US11434273
申请日:2006-05-15
IPC分类号: C07K7/00
CPC分类号: C07D471/04 , A61K38/00 , C07D471/06 , C07K14/6555
摘要: Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is: 6-n-propyl-8β-ergolinglmethylthioacetyl-D-Phe-c(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH2
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公开(公告)号:US08178651B2
公开(公告)日:2012-05-15
申请号:US12456715
申请日:2009-06-22
IPC分类号: C07K7/00
CPC分类号: C07D471/04 , A61K38/00 , C07D471/06 , C07K14/6555
摘要: Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is: 6-n-propyl-8β-ergolinglmethylthioacetyl-D-Phe-c(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH2.
摘要翻译: 公开了一系列在体内保持生长抑素和多巴胺活性的生长抑素 - 多巴胺嵌合类似物。 一个例子是:6-正丙基-8β-麦角酰甲基硫代乙酰基-D-Phe-c(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH 2。
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公开(公告)号:US20090275501A1
公开(公告)日:2009-11-05
申请号:US12456715
申请日:2009-06-22
IPC分类号: A61K38/12 , A61K31/4745 , A61P35/00
CPC分类号: C07D471/04 , A61K38/00 , C07D471/06 , C07K14/6555
摘要: Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is: 6-n-propyl-8β-ergolinglmethylthioacetyl-D-Phe-c(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH2
摘要翻译: 公开了一系列在体内保持生长抑素和多巴胺活性的生长抑素 - 多巴胺嵌合类似物。 一个例子是:6-正丙基-β-麦角酰甲基硫代乙酰基-D-Phe-c(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH2
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公开(公告)号:US20100279922A1
公开(公告)日:2010-11-04
申请号:US11988533
申请日:2006-07-10
IPC分类号: A61K38/12 , C07K7/54 , A61P29/00 , A61P19/02 , A61P3/04 , A61P35/00 , A61P9/00 , A61P11/06 , A61P17/06 , A61P17/02 , A61P17/10 , A61P25/22 , A61P25/24 , A61P37/06 , A61P5/00 , A61P15/00 , A61P25/32
CPC分类号: C07K7/06 , A61K38/00 , C07K7/08 , C07K14/665
摘要: The present invention is directed to compounds according to formula, (R2R3)-A1-c(A2-A3-A4-A5-A6-A7-A8-A9)-A10-R1, and pharmaceutically-acceptable salts thereof that act as ligands for one or more of the melanocortin receptors, to methods of using such compounds to treat mammals and to pharmaceutical compositions comprising said compounds.
摘要翻译: 本发明涉及下式的化合物:(R2R3)-A1-c(A2-A3-A4-A5-A6-A7-A8-A9)-A10-R1及其药物上可接受的盐作为配体 对于一种或多种黑皮质素受体,使用这些化合物治疗哺乳动物的方法和包含所述化合物的药物组合物。
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公开(公告)号:US09458195B2
公开(公告)日:2016-10-04
申请号:US13074565
申请日:2011-03-29
IPC分类号: A61K38/00 , C07K7/00 , C07K7/06 , C07K7/08 , C07K14/665
CPC分类号: C07K7/06 , A61K38/00 , C07K7/08 , C07K14/665
摘要: The present invention is directed to compounds according to formula, (R2R3)-A1-c(A2-A3-A4-A5-A6-A7-A8-A9)-A10-R1, and pharmaceutically-acceptable salts thereof that act as ligands for one or more of the melanocortin receptors, to methods of using such compounds to treat mammals and to pharmaceutical compositions comprising said compounds.
摘要翻译: 本发明涉及下列化合物:ƒ€ƒ€ƒ€ƒ€ƒ€ƒAc-Arg-c(Cys-D-Ala-His-D-Phe-Arg-Trp -Cys)-NH 2及其药学上可接受的盐。 该化合物作为一种或多种黑皮质素受体的配体。 本发明还涉及使用该化合物治疗哺乳动物的方法和包含所述化合物的药物组合物。
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公开(公告)号:US08349797B2
公开(公告)日:2013-01-08
申请号:US11988468
申请日:2006-07-10
IPC分类号: A61K38/12 , A61K38/16 , A61K38/22 , C07K14/575 , C07K14/665
CPC分类号: C07K14/685 , A61K38/00 , C07K14/69 , C07K14/695
摘要: The present invention is directed to a compound according to formula, (R2R3)-B1-A1-c(A2-A3-A4-A5-A6-A7-A8-A9)-A10-A11-A12-A13-B2-B3-R1, that act as ligands for one or more of the melanocortin receptors, the pharmaceutically-acceptable salts thereof, to methods of using such peptides to treat mammals and to pharmaceutical compositions useful therefore comprising said peptides.
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公开(公告)号:US08039435B2
公开(公告)日:2011-10-18
申请号:US11988533
申请日:2006-07-10
IPC分类号: A61K38/00
CPC分类号: C07K7/06 , A61K38/00 , C07K7/08 , C07K14/665
摘要: The present invention is directed to compounds according to formula, (R2R3)-A1-c(A2-A3-A4-A5-A6-A7-A8-A9)-A10-R1, and pharmaceutically-acceptable salts thereof that act as ligands for one or more of the melanocortin receptors, to methods of using such compounds to treat mammals and to pharmaceutical compositions comprising said compounds.
摘要翻译: 本发明涉及下式的化合物:(R2R3)-A1-c(A2-A3-A4-A5-A6-A7-A8-A9)-A10-R1及其药物上可接受的盐作为配体 对于一种或多种黑皮质素受体,使用这些化合物治疗哺乳动物的方法和包含所述化合物的药物组合物。
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