公开(公告)号：US20060223047A1

公开(公告)日：2006-10-05

申请号：US11440152

申请日：2006-05-25

申请人： Michael Dancu ,  John Tarbell

发明人： Michael Dancu ,  John Tarbell

IPC分类号： A01N1/02 ,  C12M1/36 ,  C12M3/00

CPC分类号： G09B23/28 ,  Y10S623/916 ,  Y10S623/917 ,  Y10S623/921

摘要： A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one pump for circulating the fluid within the system. Fluid can be tissue culture medium or blood analog fluid, and the vessel may include mammalian cells attached to its inside. A drive system, comprising two reciprocating drive shafts that are coupled by a cam, enables the uncoupling of pulsatile flow and pulsatile pressure to provide independent control over wall shear stress and circumferential strain. The shaft drives two pumps that are 180 degrees out-of-phase and are connected upstream and downstream of the vessel, and effect this uncoupling.

公开(公告)号：US20060223049A1

公开(公告)日：2006-10-05

申请号：US11440156

申请日：2006-05-25

申请人： Michael Dancu ,  John Tarbell

发明人： Michael Dancu ,  John Tarbell

IPC分类号： A01N1/02 ,  C12M1/36 ,  C12M3/00

CPC分类号： G09B23/28 ,  Y10S623/916 ,  Y10S623/917 ,  Y10S623/921

摘要： A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one pump for circulating the fluid within the system. Fluid can be tissue culture medium or blood analog fluid, and the vessel may include mammalian cells attached to its inside. A drive system, comprising two reciprocating drive shafts that are coupled by a cam, enables the uncoupling of pulsatile flow and pulsatile pressure to provide independent control over wall shear stress and circumferential strain. The shaft drives two pumps that are 180 degrees out-of-phase and are connected upstream and downstream of the vessel, and effect this uncoupling.

公开(公告)号：US20060223046A1

公开(公告)日：2006-10-05

申请号：US11440091

申请日：2006-05-25

申请人： Michael Dancu ,  John Tarbell

发明人： Michael Dancu ,  John Tarbell

IPC分类号： A01N1/02 ,  C12M3/00 ,  C12M1/36

CPC分类号： G09B23/28 ,  Y10S623/916 ,  Y10S623/917 ,  Y10S623/921

摘要： A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one pump for circulating the fluid within the system. Fluid can be tissue culture medium or blood analog fluid, and the vessel may include mammalian cells attached to its inside. A drive system, comprising two reciprocating drive shafts that are coupled by a cam, enables the uncoupling of pulsatile flow and pulsatile pressure to provide independent control over wall shear stress and circumferential strain. The shaft drives two pumps that are 180 degrees out-of-phase and are connected upstream and downstream of the vessel, and effect this uncoupling.

公开(公告)号：US20060223048A1

公开(公告)日：2006-10-05

申请号：US11440155

申请日：2006-05-25

申请人： Michael Dancu ,  John Tarbell

发明人： Michael Dancu ,  John Tarbell

IPC分类号： A01N1/02 ,  C12M1/36 ,  C12M3/00

CPC分类号： G09B23/28 ,  Y10S623/916 ,  Y10S623/917 ,  Y10S623/921

摘要： A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one pump for circulating the fluid within the system. Fluid can be tissue culture medium or blood analog fluid, and the vessel may include mammalian cells attached to its inside. A drive system, comprising two reciprocating drive shafts that are coupled by a cam, enables the uncoupling of pulsatile flow and pulsatile pressure to provide independent control over wall shear stress and circumferential strain. The shaft drives two pumps that are 180 degrees out-of-phase and are connected upstream and downstream of the vessel, and effect this uncoupling.

公开(公告)号：US20060210959A1

公开(公告)日：2006-09-21

申请号：US11440148

申请日：2006-05-25

申请人： Michael Dancu ,  John Tarbell

发明人： Michael Dancu ,  John Tarbell

IPC分类号： A01N1/02 ,  C12M3/00 ,  C12M1/36

CPC分类号： G09B23/28 ,  Y10S623/916 ,  Y10S623/917 ,  Y10S623/921

摘要： A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one pump for circulating the fluid within the system. Fluid can be tissue culture medium or blood analog fluid, and the vessel may include mammalian cells attached to its inside. A drive system, comprising two reciprocating drive shafts that are coupled by a cam, enables the uncoupling of pulsatile flow and pulsatile pressure to provide independent control over wall shear stress and circumferential strain. The shaft drives two pumps that are 180 degrees out-of-phase and are connected upstream and downstream of the vessel, and effect this uncoupling.

公开(公告)号：US20080262605A1

公开(公告)日：2008-10-23

申请号：US12019533

申请日：2008-01-24

申请人： Michael Dancu

发明人： Michael Dancu

IPC分类号： A61F2/06 ,  C12N11/02 ,  C12N11/14 ,  C12M1/00 ,  C12N11/10

CPC分类号： G09B23/28 ,  G09B23/30 ,  Y10S623/915 ,  Y10S623/916 ,  Y10S623/921

摘要： Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can promote endothelialization of a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft by placing the hybrid hemodialysis access graft or the hybrid femoral artery bypass graft in a system embodiment according to the invention under conditions effective to promote endothelial cells to form a confluent monolayer on the surface of the hybrid graft.

摘要翻译： 混合合成移植物和用于产生混合血管移植物的系统和方法的实施方案，其可产生将合成移植物与活细胞组合的可植入移植物。 系统的实施例可以包括压力/流动回路子系统，其具有耦合到样本保持器的外部流动回路系统，其中压力/流动回路子系统能够调节样本保持器中的至少两个动态条件或样本的直径 样品架。 方法的实施方案可以通过在有效促进内皮细胞形成的条件下将根据本发明的系统实施方案中放置混合血液透析入口移植物或混合股动脉旁路移植物来促进混合血液透析进入移植物或混合股动脉旁路移植物的内皮化 在混合移植物的表面上的汇合单层。

公开(公告)号：US20080255408A1

公开(公告)日：2008-10-16

申请号：US12018990

申请日：2008-01-24

申请人： Michael Dancu

发明人： Michael Dancu

IPC分类号： A61F2/06

CPC分类号： G09B23/285

摘要： Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can promote endothelialization of a hybrid lower limb artery bypass vascular graft by placing the hybrid lower limb artery bypass vascular graft in a system embodiment according to the invention under conditions effective to promote stem cells to form a confluent monolayer on the hybrid vascular graft.

摘要翻译： 混合合成移植物和用于产生混合血管移植物的系统和方法的实施方案，其可产生将合成移植物与活细胞组合的可植入移植物。 系统的实施例可以包括压力/流动回路子系统，其具有耦合到样本保持器的外部流动回路系统，其中压力/流动回路子系统能够调节样本保持器中的至少两个动态条件或样本的直径 样品架。 方法的实施方案可以通过将杂交下肢动脉旁路血管移植物置于根据本发明的系统实施方案中，在有效促进干细胞在杂交血管移植物上形成汇合单层的条件下，促进混合下肢动脉旁路血管移植物的内皮化 。

公开(公告)号：US20080234805A1

公开(公告)日：2008-09-25

申请号：US12018948

申请日：2008-01-24

申请人： Michael Dancu

发明人： Michael Dancu

IPC分类号： A61F2/06

CPC分类号： G09B23/28

摘要： Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can prepare a hybrid lower limb artery bypass vascular graft intended for implantation into a mammal by placing the hybrid lower limb artery bypass vascular graft in a system embodiment according to the invention prior to implantation of the hybrid lower limb artery bypass vascular graft into the mammal.

摘要翻译： 混合合成移植物和用于产生混合血管移植物的系统和方法的实施方案，其可产生将合成移植物与活细胞组合的可植入移植物。 系统的实施例可以包括压力/流动回路子系统，其具有耦合到样本保持器的外部流动回路系统，其中压力/流动回路子系统能够调节样本保持器中的至少两个动态条件或样本的直径 样品架。 方法的实施例可以通过将混合下肢动脉旁路血管移植物放置在根据本发明的系统实施例中，在植入混合下肢动脉旁路血管移植物之前，制备用于植入哺乳动物的混合下肢动脉旁路血管移植物 哺乳动物。

公开(公告)号：US20080234801A1

公开(公告)日：2008-09-25

申请号：US12018895

申请日：2008-01-24

申请人： Michael Dancu

发明人： Michael Dancu

IPC分类号： A61F2/06

CPC分类号： G09B23/28

摘要： Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can promote engraftment of a hybrid carotid bypass vascular graft following implantation into a mammal's body by placing the hybrid carotid bypass vascular graft in a system embodiment according to the invention prior to implantation of the hybrid carotid bypass vascular graft into the mammal's body.

摘要翻译： 混合合成移植物和用于产生混合血管移植物的系统和方法的实施方案，其可产生将合成移植物与活细胞组合的可植入移植物。 系统的实施例可以包括压力/流动回路子系统，其具有耦合到样本保持器的外部流动回路系统，其中压力/流动回路子系统能够调节样本保持器中的至少两个动态条件或样本的直径 样品架。 方法的实施方案可以在将混合型颈动脉旁路血管移植物植入哺乳动物体内之前，通过将混合型颈动脉旁路血管移植物放置在根据本发明的系统实施例中来促进植入哺乳动物体内的混合型颈动脉旁路血管移植物植入。

公开(公告)号：US08039246B2

公开(公告)日：2011-10-18

申请号：US12019533

申请日：2008-01-24

申请人： Michael Dancu

发明人： Michael Dancu

IPC分类号： A01N1/00 ,  A01N1/02 ,  C12M1/00 ,  C12M3/00

CPC分类号： G09B23/28 ,  G09B23/30 ,  Y10S623/915 ,  Y10S623/916 ,  Y10S623/921

摘要： Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can promote endothelialization of a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft by placing the hybrid hemodialysis access graft or the hybrid femoral artery bypass graft in a system embodiment according to the invention under conditions effective to promote endothelial cells to form a confluent monolayer on the surface of the hybrid graft.

摘要翻译： 混合合成移植物和用于产生混合血管移植物的系统和方法的实施方案，其可产生将合成移植物与活细胞组合的可植入移植物。 系统的实施例可以包括压力/流动回路子系统，其具有耦合到样本保持器的外部流动回路系统，其中压力/流动回路子系统能够调节样本保持器中的至少两个动态条件或样本的直径 样品架。 方法的实施方案可以通过在有效促进内皮细胞形成的条件下将根据本发明的系统实施方案中放置混合血液透析入口移植物或混合股动脉旁路移植物来促进混合血液透析进入移植物或混合股动脉旁路移植物的内皮化 在混合移植物的表面上的汇合单层。