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公开(公告)号:US06331411B1
公开(公告)日:2001-12-18
申请号:US09153277
申请日:1998-09-15
申请人: Michael Gwynn , Howard Kallender , Lisa K Katz , Daniel Sylvester , Christopher M Traini , Richard Lloyd Warren
发明人: Michael Gwynn , Howard Kallender , Lisa K Katz , Daniel Sylvester , Christopher M Traini , Richard Lloyd Warren
IPC分类号: C12N510
CPC分类号: C12N9/90 , A61K38/00 , C07K14/3156 , C12Q1/689
摘要: The invention provides topA polypeptides and polynucleotides encoding topA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing topA polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了topA多肽和编码topA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用topA多肽筛选抗菌化合物的方法。
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公开(公告)号:US20070003553A1
公开(公告)日:2007-01-04
申请号:US11201592
申请日:2005-08-11
申请人: Michael Blackburn , William Church , Giora Feuerstein , Mitchell Gross , Andrew Nichols , Eduardo Padlan , Arunbhai Patel , Daniel Sylvester
发明人: Michael Blackburn , William Church , Giora Feuerstein , Mitchell Gross , Andrew Nichols , Eduardo Padlan , Arunbhai Patel , Daniel Sylvester
IPC分类号: A61K39/395 , A61K31/60
CPC分类号: C07K16/36 , A61K38/00 , A61K39/395 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要: Chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
摘要翻译: 提供衍生自高亲和力中和mAb的嵌合,人源化和其它IL-5mAb,含有其的药物组合物,治疗方法和诊断。
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3.Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders 失效
标题翻译: 可用于治疗IL4介导的疾病的重组IL4抗体公开(公告)号:US20060263853A1
公开(公告)日:2006-11-23
申请号:US11493692
申请日:2006-07-26
申请人: Stephen Holmes , Mitchell Gross , Daniel Sylvester
发明人: Stephen Holmes , Mitchell Gross , Daniel Sylvester
CPC分类号: C07K16/247 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/6869
摘要: Chimeric and humanized IL4 A MAbs derived from affinity MAbs, pharmaceutical compositions containing same, and methods of treatment are provided.
摘要翻译: 嵌合和人源化IL4A提供衍生自亲和性MAb的MAb,含有它们的药物组合物和治疗方法。
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4.Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders 审中-公开
标题翻译: 可用于治疗IL4介导的疾病的重组IL4抗体公开(公告)号:US20050002959A1
公开(公告)日:2005-01-06
申请号:US10723872
申请日:2003-11-26
申请人: Stephen Holmes , Mitchell Gross , Daniel Sylvester
发明人: Stephen Holmes , Mitchell Gross , Daniel Sylvester
CPC分类号: C07K16/247 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/6869
摘要: Chimeric and humanized IL4 MAbs derived from affinity MAbs, pharmaceutical compositions containing same, and methods of treatment are provided.
摘要翻译: 提供衍生自亲和性MAb的嵌合和人源化IL4 MAb,含有其的药物组合物和治疗方法。
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