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公开(公告)号:US06649618B2
公开(公告)日:2003-11-18
申请号:US09906296
申请日:2001-07-16
申请人: Michael Härter , Barbara Albrecht , Michael Gerisch , Gabriele Handke , Joachim Hütter , Axel Jensen , Thomas Krahn , Joachim Mittendorf , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
发明人: Michael Härter , Barbara Albrecht , Michael Gerisch , Gabriele Handke , Joachim Hütter , Axel Jensen , Thomas Krahn , Joachim Mittendorf , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
IPC分类号: C07D491048
CPC分类号: C07D401/06 , C07D239/96 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D411/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D487/04 , C07D495/04 , C07D513/04
摘要: Novel amidoalkyl-uracil derivatives of the formula (I) in which A represents 1-3 ring atoms and X represents optionally substituted (C2-C10)alkylene or (C3-C8)cycloalkylene as defined in claim 1, a process for their preparation, and their use as medicaments for the prophylaxis and/or treatment of disorders are described.
摘要翻译: 式(I)的新型酰氨基烷基 - 尿嘧啶衍生物,其中A表示1-3个环原子,X表示如权利要求1所定义的任选取代的(C 2 -C 10)亚烷基或(C 3 -C 8)亚环烷基,其制备方法, 并描述其用作预防和/或治疗病症的药物。
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2.Substituted amidoalkyl uracils and their use as inhibitors of the poly(adp-ribose) synthetase (pars) 失效
标题翻译: 取代的酰氨基烷基尿嘧啶及其作为聚(adp-核糖)合成酶(pars)抑制剂的用途公开(公告)号:US20050075347A1
公开(公告)日:2005-04-07
申请号:US10416622
申请日:2001-11-02
申请人: Barbara Albrecht , Michael Gerisch , Gabriele Handke-Erguden , Axel Jensen , Thomas Krahn , Werner Nickl , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
发明人: Barbara Albrecht , Michael Gerisch , Gabriele Handke-Erguden , Axel Jensen , Thomas Krahn , Werner Nickl , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
IPC分类号: C07D239/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D491/04 , C07D495/04 , C07D519/00 , C07D521/00 , A61K31/519
CPC分类号: C07D231/12 , C07D233/56 , C07D239/96 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D491/04 , C07D495/04
摘要: The invention relates to novel amidoalkyl uracil derivatives of formula (I), to a method for the production thereof, and to their use as medicament active substances for the prophylaxis and/or treatment of medical disorders.
摘要翻译: 本发明涉及式(I)的新型酰氨基烷基尿嘧啶衍生物,其制备方法及其作为用于预防和/或治疗医学病症的药物活性物质的用途。
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3.Substituted amidoalkyl uracils and their use as inhibitors of the poly(adp-ribose) synthetase (PARS) 失效
标题翻译: 取代的酰氨基烷基尿嘧啶及其作为聚(adp-核糖)合成酶(PARS)的抑制剂的用途公开(公告)号:US07125995B2
公开(公告)日:2006-10-24
申请号:US10416622
申请日:2001-11-02
申请人: Barbara Albrecht , Michael Gerisch , Gabriele Handke-Ergüden , Axel Jensen , Thomas Krahn , Werner Nickl , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
发明人: Barbara Albrecht , Michael Gerisch , Gabriele Handke-Ergüden , Axel Jensen , Thomas Krahn , Werner Nickl , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
IPC分类号: C07D239/70 , C07D493/04 , C07D495/04 , A61K31/517 , A61P9/10
CPC分类号: C07D231/12 , C07D233/56 , C07D239/96 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D491/04 , C07D495/04
摘要: This application relates to compounds of formula (I) below in which the several variable groups are as defined in the specification and claims, to methods of preparing these materials, to pharmaceutical compositions containing these materials, and to methods of using these materials to treat ischaemia or reperfusion damage.
摘要翻译: 本申请涉及以下式(I)的化合物,其中几个可变基团如说明书和权利要求中所定义,制备这些材料的方法,含有这些材料的药物组合物以及使用这些材料来治疗局部缺血的方法 或再灌注损伤。
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公开(公告)号:US20050159431A1
公开(公告)日:2005-07-21
申请号:US10501033
申请日:2003-01-03
申请人: Barbara Albrecht , Michael Gerisch , Michael Harter , Thomas Krahn , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
发明人: Barbara Albrecht , Michael Gerisch , Michael Harter , Thomas Krahn , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
IPC分类号: A61P9/10 , C07D239/96 , C07D401/06 , C07D403/06 , C07D409/12 , C07D491/04 , C07D491/052 , C07D495/04 , A61K31/519 , A61K31/517 , C07D491/02 , C07D498/02
CPC分类号: C07D401/06 , C07D239/96 , C07D403/06 , C07D409/12 , C07D491/04 , C07D495/04
摘要: The invention relates to novel compounds of formula (I), to a method for the production thereof, and to their use as medicament active ingredients for the prophylaxis and/or treatment of diseases.
摘要翻译: 本发明涉及式(I)的新型化合物,其制备方法及其作为预防和/或治疗疾病的药物活性成分的用途。
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公开(公告)号:US07074780B2
公开(公告)日:2006-07-11
申请号:US10715283
申请日:2003-11-17
申请人: Erwin Bischoff , Thomas Krahn , Stephan-Nicholas Müller , Holger Paulsen , Joachim Schuhmacher , Henning Steinhagen , Wolfgang Thielemann
发明人: Erwin Bischoff , Thomas Krahn , Stephan-Nicholas Müller , Holger Paulsen , Joachim Schuhmacher , Henning Steinhagen , Wolfgang Thielemann
IPC分类号: A61K31/33 , A61K31/38 , A61K31/16 , C07D331/02 , C07D333/02
CPC分类号: C07D213/40 , C07C233/63 , C07C235/12 , C07C235/40 , C07C237/24 , C07C271/16 , C07C271/20 , C07C271/22 , C07C271/24 , C07C275/26 , C07C275/42 , C07C317/50 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D213/56 , C07D213/75 , C07D213/81 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/205 , C07D295/215
摘要: The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) to processes for their preparation and to their use in medicaments, in particular for the prevention and/or treatment of cardiovascular disorders.
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公开(公告)号:US06649616B2
公开(公告)日:2003-11-18
申请号:US09943325
申请日:2001-08-30
申请人: Erwin Bischoff , Thomas Krahn , Stephan-Nicholas Müller , Holger Paulsen , Joachim Schuhmacher , Henning Steinhagen , Wolfgang Thielemann
发明人: Erwin Bischoff , Thomas Krahn , Stephan-Nicholas Müller , Holger Paulsen , Joachim Schuhmacher , Henning Steinhagen , Wolfgang Thielemann
IPC分类号: A61K3133
CPC分类号: C07D213/40 , C07C233/63 , C07C235/12 , C07C235/40 , C07C237/24 , C07C271/16 , C07C271/20 , C07C271/22 , C07C271/24 , C07C275/26 , C07C275/42 , C07C317/50 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D213/56 , C07D213/75 , C07D213/81 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/205 , C07D295/215
摘要: The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) to processes for their preparation and to their use in medicaments, in particular for the prevention and/or treatment of cardiovascular disorders.
摘要翻译: 本发明涉及式(I)的取代的苯基环己烷甲酰胺,用于其制备方法及其在药物中的用途,特别是用于预防和/或治疗心血管疾病。
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7.Substituted phenylcyclohexane carboxylic acid amides and their use as adenosine uptake inhibitors 失效
标题翻译: 取代的苯基环己烷羧酸酰胺及其作为腺苷摄取抑制剂的用途公开(公告)号:US06984642B1
公开(公告)日:2006-01-10
申请号:US09980242
申请日:2000-05-16
申请人: Erwin Bischoff , Stephan Lensky , Stephan-Nicholas Müller , Holger Paulsen , Jörg Keldenich , Thomas Krahn , Joachim Schuhmacher , Jan Jänichen , Wolfgang Thielemann , Henning Steinhagen
发明人: Erwin Bischoff , Stephan Lensky , Stephan-Nicholas Müller , Holger Paulsen , Jörg Keldenich , Thomas Krahn , Joachim Schuhmacher , Jan Jänichen , Wolfgang Thielemann , Henning Steinhagen
IPC分类号: A61K31/496 , C07D403/04
CPC分类号: C07D235/24 , A61K31/4184 , A61K31/437 , C07D235/12 , C07D235/14 , C07D235/30 , C07D471/04
摘要: The present invention relates to substituted phenylcyclohexanecaboxamides of the formula (I), to processes for their preparation and to their use in medicaments, in particular for treating cardiovascular disorders.
摘要翻译: 本发明涉及式(I)的取代的苯基环己烷甲酰胺,其制备方法及其在药物中的用途,特别是用于治疗心血管疾病。
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8.Substituted piperazine cyclohexane carboxilic acid amides and the use thereof 审中-公开
标题翻译: 取代的哌嗪环己烷羧酸酰胺及其用途公开(公告)号:US20050054637A1
公开(公告)日:2005-03-10
申请号:US10492337
申请日:2002-10-01
申请人: Erwin Bischoff , Thomas Krahn , Holger Paulsen , Joachim Schuhmacher , Henning Steinhagen , Wolfgang Thielemann
发明人: Erwin Bischoff , Thomas Krahn , Holger Paulsen , Joachim Schuhmacher , Henning Steinhagen , Wolfgang Thielemann
IPC分类号: C07D295/14 , A61K31/495 , A61K31/496 , A61K31/501 , A61P7/02 , A61P7/10 , A61P9/08 , A61P9/10 , A61P19/08 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/20 , A61P35/00 , A61P43/00 , C07D207/34 , C07D207/40 , C07D207/416 , C07D209/08 , C07D209/42 , C07D213/38 , C07D213/71 , C07D213/81 , C07D213/82 , C07D215/12 , C07D215/50 , C07D215/54 , C07D217/26 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/84 , C07D233/90 , C07D235/04 , C07D237/24 , C07D261/14 , C07D275/04 , C07D295/155 , C07D295/18 , C07D295/192 , C07D295/20 , C07D295/215 , C07D295/22 , C07D295/26 , C07D307/68 , C07D317/58 , C07D317/68 , C07D333/34 , C07D333/38 , C07D417/02 , C07D413/02 , C07D43/02
CPC分类号: C07D207/416 , C07D213/71 , C07D231/56 , C07D295/155 , C07D295/192 , C07D295/215 , C07D295/26 , C07D333/38
摘要: The present invention relates to substituted piperazinecyclohexanecarboxamides of the formula (I) to processes for their preparation and to their use in pharmaceuticals, in particular for the prophylaxis and/or treatment of cardiovascular disorders.
摘要翻译: 本发明涉及式(I)的取代的哌嗪环己烷甲酰胺,其制备方法及其在药物中的用途,特别是用于预防和/或治疗心血管疾病。
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9.Use of Adenosine A1 and/or Dual A1/2ab Agonists for Production of Medicaments for Treating Diseases 审中-公开
标题翻译: 使用腺苷A1和/或双重A1 / 2ab激动剂生产用于治疗疾病的药物公开(公告)号:US20100048641A1
公开(公告)日:2010-02-25
申请号:US12224417
申请日:2007-02-16
申请人: Peter Nell , Barbara Albrecht-Küpper , Walter Hübsch , Martina Wuttke , Thomas Krahn , Nicole Diedrichs , Hilmar Bischoff
发明人: Peter Nell , Barbara Albrecht-Küpper , Walter Hübsch , Martina Wuttke , Thomas Krahn , Nicole Diedrichs , Hilmar Bischoff
IPC分类号: A61K31/4439 , C07D417/12 , A61P3/00 , A61P3/10
CPC分类号: C07D417/12
摘要: The present invention relates to the use of A1 and/or dual A1/A2b agonists of the formulae (IA) and (IB) for preparing a medicament for treating dyslipidemia, metabolic syndrome and diabetes and dyslipidemia, metabolic syndrome and diabetes in association with hypertension and cardiovascular disorders.
摘要翻译: 本发明涉及式(IA)和(IB)的A1和/或双重A1 / A2b激动剂在制备用于治疗血脂异常,代谢综合征和糖尿病和血脂异常,代谢综合征和与高血压相关的糖尿病的药物中的用途 和心血管疾病。
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公开(公告)号:US08703696B2
公开(公告)日:2014-04-22
申请号:US12671694
申请日:2008-07-23
申请人: Hans-Georg Lerchen , Ursula Krenz , Joerg Keldenich , Nicole Diedrichs , Thomas Krahn , Claudia Hirth-Dietrich , Barbara Albrecht-Küpper
发明人: Hans-Georg Lerchen , Ursula Krenz , Joerg Keldenich , Nicole Diedrichs , Thomas Krahn , Claudia Hirth-Dietrich , Barbara Albrecht-Küpper
IPC分类号: A61K38/00 , A61K31/44 , C07D417/00
CPC分类号: A61K47/48246 , A61K31/4439 , A61K47/542 , A61K47/64 , C07D417/12 , C07K5/06086
摘要: The present application relates to prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.
摘要翻译: 本申请涉及2-氨基-6 - ({[2-(4-氯苯基)-1,3-噻唑-4-基]甲基}硫代)-4- [4-(2-羟基乙氧基) 苯基]吡啶-3,5-二腈,其制备方法,它们用于治疗和/或预防疾病的用途,及其用于制备用于治疗和/或预防疾病,特别是心血管疾病的药物的用途。
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