摘要:
A bogie for a locomotive comprising a bogie frame and at least one wheel set including two wheels, a wheel set gear, a wheel set shaft and a wheel set gear housing. A push/pull rod acts on one side of the bogie frame and on the other side of locomotive frame and transfers forces between the two. The gear housing of the wheel set exhibits a recess for the feeding through of the push/pull rod, the recess being bordered by walls which are integral with the remaining housing walls.
摘要:
The invention relates to a bogie for a locomotivewith a bogie framewith at least one wheel set, comprising two wheels, a wheel set gear, a wheel set shaft and a wheel set gear housing;with a push/pull rod, which acts on one side on the bogie frame and on the other side on the locomotive frame and transfers forces between these two.The invention is characterized by the following features:the gear housing of the wheel set exhibits a recess for the feeding through of the push/pull rod;the recess is bordered by walls which are integral with the remaining housing walls.
摘要:
A rotary elastic coupling is fitted with an inner ring and with an outer ring surrounding the inner ring around the periphery by forming an annular slit. An elastomer is provided in the annular slit, which is vulcanized or glued to the inner ring and to the outer ring and fills up the annular slit substantially or completely. The annular slit is meander-shaped around the periphery of the coupling so that radially outward protrusions of the inner ring undercut radially inward protrusions of the outer ring. Around the periphery of the coupling, a relief opening is provided in the elastomer on both sides of the protrusions of the inner ring and on both sides of the protrusions of the outer ring.
摘要:
The present invention relates to a rotary elastic coupling fitted with an inner ring and with an outer ring surrounding the inner ring around the periphery by forming an annular slit. An elastomer is provided in the annular slit, which is vulcanised or glued to the inner ring and to the outer ring and fills up the annular slit substantially or completely. The annular slit is meander-shaped around the periphery of the coupling so that radially outward protrusions of the inner ring undercut radially inward protrusions of the outer ring. Around the periphery of the coupling, a relief opening is provided in the elastomer on both sides of the protrusions of the inner ring and on both sides of the protrusions of the outer ring.
摘要:
The invention relates to antibodies to the tumor-associated antigen CD33 and to the use thereof for immunotargeting CD33-positive cells. The antibodies according to the invention are suitable for use in the field of medicine, pharmaceuticals, and biomedical research. According to the invention, the aim is achieved by means of novel anti-CD33 antibodies comprising the complementary determining regions (CDRs) defined in the claim. The antibodies according to the invention are characterized by a high affinity for human CD33, of the order of magnitude of 10−10 mol/l. The CDR sequences according to the invention are suitable in particular for producing recombinant fragments (such as scFv fragments or bispecific antibodies) and for immunotargeting, due to the high affinity thereof. The invention further relates to the use of an antibody according to the invention for producing a medication for therapeutic and/or diagnostic application for illnesses associated with the expression of CD33, particularly for acute myeloid leukemia (AML). The invention thus also comprises a pharmaceutical composition comprising one or more antibodies according to the invention in association with a pharmaceutically acceptable thinning agent or carrier.
摘要:
The invention relates to antibodies against the human La protein and to their use in immunotargeting, in particular the immunotargeting of tumor cells. The object of the invention is to provide improved antibodies which bind universal target structures on the surface of tumor cells, and to provide novel anti-La antibodies, in particular with a high affinity for La, a universal target structure on tumor cells, which make it possible to use the antibodies as recombinant fragments for immunotargeting. The invention comprises recombinant antibodies comprising: i. a binding unit of an antibody which specifically binds to an epitope of a human nuclear antigen, preferably human La protein, and ii. a binding unit of an antibody which specifically binds to an effector cell or of a ligand which specifically binds to an effector cell. The invention furthermore comprises novel antibodies which specifically bind the human La protein.
摘要:
A method for holding a vehicle at a standstill includes a first phase in which the brake pressure at the wheel brakes is retained so that the vehicle is held automatically by the service brake, and the braking force is then transferred to a parking brake so that in a second phase the vehicle is held solely by the parking brake. A risk inherent in this transfer is that the vehicle may begin to slip. The distance over which the vehicle slides in uncontrolled fashion can be made substantially shorter if, in the second phase in which the vehicle is being held by the parking brake, the movement of the vehicle is monitored by sensors, and brake pressure is automatically built up by way of an actuator as soon as the fact that the vehicle is rolling away has been detected.
摘要:
The invention relates to antibodies to the tumor-associated antigen CD33 and to the use thereof for immunotargeting CD33-positive cells. The antibodies according to the invention are suitable for use in the field of medicine, pharmaceuticals, and biomedical research. According to the invention, the aim is achieved by means of novel anti-CD33 antibodies comprising the complementary determining regions (CDRs) defined in the claim. The antibodies according to the invention are characterized by a high affinity for human CD33, of the order of magnitude of 1010 mol/l. The CDR sequences according to the invention are suitable in particular for producing recombinant fragments (such as scFv fragments or bispecific antibodies) and for immunotargeting, due to the high affinity thereof. The invention further relates to the use of an antibody according to the invention for producing a medication for therapeutic and/or diagnostic application for illnesses associated with the expression of CD33, particularly for acute myeloid leukemia (AML). The invention thus also comprises a pharmaceutical composition comprising one or more antibodies according to the invention in association with a pharmaceutically acceptable thinning agent or carrier.
摘要:
The invention relates to a composition which contains at least one anti-slan antibody and to its diagnostic and therapeutic use. The composition according to the invention comprises: a) at least one anti-slan antibody, b) at least one binding unit which binds to a co-stimulus binding to a co-stimulus-specific receptor on dendritic cells, thereby bringing about the modulation, preferably the activation, of said dendritic cells, and c) at least one antigen. The invention furthermore comprises anti-slan antibodies which include CDRs with the following sequences: variable region of the heavy chain: CDR1 (SEQ ID No. 1), CDR2 (SEQ ID No. 2), where Xaa is selected from among M, L, F, or I, preferably from among M or I, CDR3 (SEQ ID No. 5) and variable region of the light chain: CDR1 (SEQ ID No. 6), where Xaa is selected from among S, T, N, Q, H, K or R, preferably from among S or N, CDR2 (SEQ ID No. 9) and CDR3 (SEQ ID No. 10).
摘要翻译:本发明涉及含有至少一种抗唾液酸抗体及其诊断和治疗用途的组合物。 根据本发明的组合物包含:a)至少一种抗蝙蝠抗体,b)至少一个结合单元,其结合共刺激与树突状细胞上的共刺激特异性受体的结合,由此引起调节 ,优选活化所述树突状细胞,和c)至少一种抗原。 本发明还包括抗an抗体,其包括具有以下序列的CDR:重链可变区:CDR1(SEQ ID No.1),CDR2(SEQ ID No.2),其中Xaa选自M,L ,F或I,优选M或I,CDR3(SEQ ID No.5)和轻链可变区:CDR1(SEQ ID No.6),其中Xaa选自S,T,N, Q,H,K或R,优选来自S或N,CDR2(SEQ ID No.9)和CDR3(SEQ ID No.10)。