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公开(公告)号：US20100192800A1
公开(公告)日：2010-08-05
申请号：US12668240
申请日：2008-07-03
摘要： The invention relates to a bogie for a locomotivewith a bogie framewith at least one wheel set, comprising two wheels, a wheel set gear, a wheel set shaft and a wheel set gear housing;with a push/pull rod, which acts on one side on the bogie frame and on the other side on the locomotive frame and transfers forces between these two.The invention is characterized by the following features:the gear housing of the wheel set exhibits a recess for the feeding through of the push/pull rod;the recess is bordered by walls which are integral with the remaining housing walls.
摘要翻译： 本发明涉及一种用于具有至少一个轮组的转向架框架的机车的转向架，包括两个车轮，轮组齿轮，轮组轴和轮组齿轮壳体; 具有推/拉杆，其在转向架框架的一侧上并且在机车框架的另一侧上起作用，并在这两者之间传递力。 本发明的特征在于具有以下特征：轮组的齿轮壳体具有用于推/拉杆进给的凹槽; 该凹陷部分与墙壁相邻，墙壁与剩余的房屋墙壁是一体的。
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公开(公告)号：US08196520B2
公开(公告)日：2012-06-12
申请号：US12668240
申请日：2008-07-03
IPC分类号： B61C9/00
摘要： A bogie for a locomotive comprising a bogie frame and at least one wheel set including two wheels, a wheel set gear, a wheel set shaft and a wheel set gear housing. A push/pull rod acts on one side of the bogie frame and on the other side of locomotive frame and transfers forces between the two. The gear housing of the wheel set exhibits a recess for the feeding through of the push/pull rod, the recess being bordered by walls which are integral with the remaining housing walls.
摘要翻译： 一种用于机车的转向架，包括转向架框架和至少一个包括两个轮子的轮组，轮组齿轮，轮组轴和轮组齿轮壳体。 推/拉杆作用在转向架框架的一侧和机车框架的另一侧，并在两者之间传递力。 车轮组的齿轮壳体具有用于通过推/拉杆进给的凹部，该凹部由与其余壳体壁成一体的壁边界。
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公开(公告)号：US08460114B2
公开(公告)日：2013-06-11
申请号：US12937332
申请日：2009-04-09
申请人： Markus K. Becker , Peter Frohs , Maik Marcinkowski , Michael Holzapfel , Michael Bachmann , Michael Jaros
发明人： Markus K. Becker , Peter Frohs , Maik Marcinkowski , Michael Holzapfel , Michael Bachmann , Michael Jaros
CPC分类号： F16D3/68 , F16D3/76 , Y10T29/49872 , Y10T29/49885 , Y10T29/49947 , Y10T29/49982
摘要： A rotary elastic coupling is fitted with an inner ring and with an outer ring surrounding the inner ring around the periphery by forming an annular slit. An elastomer is provided in the annular slit, which is vulcanized or glued to the inner ring and to the outer ring and fills up the annular slit substantially or completely. The annular slit is meander-shaped around the periphery of the coupling so that radially outward protrusions of the inner ring undercut radially inward protrusions of the outer ring. Around the periphery of the coupling, a relief opening is provided in the elastomer on both sides of the protrusions of the inner ring and on both sides of the protrusions of the outer ring.
摘要翻译： 旋转弹性联轴器通过形成环形狭缝而装配有内圈和围绕内周围的内圈的外圈。 弹性体设置在环形狭缝中，其被硫化或胶合到内圈和外圈上并且基本上或完全地填充环形狭缝。 所述环形狭缝围绕所述联接器的周边为曲折形状，使得所述内圈的径向向外的突出部朝向所述外环的径向向内的突出部。 在联接器的周围，在内圈的突起的两侧和外圈的突起的两侧上的弹性体中设置有释放开口。
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公开(公告)号：US20110165950A1
公开(公告)日：2011-07-07
申请号：US12937332
申请日：2009-04-09
申请人： Markus K. Becker , Peter Frohs , Maik Marcinkowski , Michael Holzapfel , Michael Bachmann , Michael Jaros
发明人： Markus K. Becker , Peter Frohs , Maik Marcinkowski , Michael Holzapfel , Michael Bachmann , Michael Jaros
CPC分类号： F16D3/68 , F16D3/76 , Y10T29/49872 , Y10T29/49885 , Y10T29/49947 , Y10T29/49982
摘要： The present invention relates to a rotary elastic coupling fitted with an inner ring and with an outer ring surrounding the inner ring around the periphery by forming an annular slit. An elastomer is provided in the annular slit, which is vulcanised or glued to the inner ring and to the outer ring and fills up the annular slit substantially or completely. The annular slit is meander-shaped around the periphery of the coupling so that radially outward protrusions of the inner ring undercut radially inward protrusions of the outer ring. Around the periphery of the coupling, a relief opening is provided in the elastomer on both sides of the protrusions of the inner ring and on both sides of the protrusions of the outer ring.
摘要翻译： 旋转弹性联轴器技术领域本发明涉及一种旋转弹性联轴器，其通过形成环形狭缝而装配有内环和围绕内周围的内圈的外圈。 弹性体设置在环形狭缝中，其被硫化或胶合到内环和外环，并且基本上或完全地填充环形狭缝。 所述环形狭缝围绕所述联接器的周边为曲折形状，使得所述内圈的径向向外的突出部朝向所述外环的径向向内的突出部。 在联接器的周围，在内圈的突起的两侧和外圈的突起的两侧上的弹性体中设置有释放开口。
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5.发明授权Anti-CD33 antibodies and use thereof for immunotargeting in treating CD33-associated illnesses 有权抗CD33抗体及其用于免疫靶向治疗CD33相关疾病的用途公开(公告)号：US08759494B2
公开(公告)日：2014-06-24
申请号：US13497800
申请日：2010-09-22
申请人： Michael Bachmann , Slava Stamova
发明人： Michael Bachmann , Slava Stamova
CPC分类号： C07K16/2803 , C07K16/2809 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/626
摘要： The invention relates to antibodies to the tumor-associated antigen CD33 and to the use thereof for immunotargeting CD33-positive cells. The antibodies according to the invention are suitable for use in the field of medicine, pharmaceuticals, and biomedical research. According to the invention, the aim is achieved by means of novel anti-CD33 antibodies comprising the complementary determining regions (CDRs) defined in the claim. The antibodies according to the invention are characterized by a high affinity for human CD33, of the order of magnitude of 10−10 mol/l. The CDR sequences according to the invention are suitable in particular for producing recombinant fragments (such as scFv fragments or bispecific antibodies) and for immunotargeting, due to the high affinity thereof. The invention further relates to the use of an antibody according to the invention for producing a medication for therapeutic and/or diagnostic application for illnesses associated with the expression of CD33, particularly for acute myeloid leukemia (AML). The invention thus also comprises a pharmaceutical composition comprising one or more antibodies according to the invention in association with a pharmaceutically acceptable thinning agent or carrier.
摘要翻译： 本发明涉及肿瘤相关抗原CD33的抗体及其用于免疫靶向CD33阳性细胞的用途。 根据本发明的抗体适用于医药，药物和生物医学研究领域。 根据本发明，目的是通过包含权利要求中定义的互补决定区（CDR）的新型抗CD33抗体来实现。 根据本发明的抗体的特征在于对人CD33的高亲和力，其数量级为10-10mol / l。 由于其高亲和力，根据本发明的CDR序列特别适用于产生重组片段（例如scFv片段或双特异性抗体）和免疫靶向。 本发明还涉及根据本发明的抗体用于产生用于与CD33表达相关的疾病的治疗和/或诊断应用的药物的用途，特别是用于急性骨髓性白血病（AML）。 因此，本发明还包含与药学上可接受的稀释剂或载体结合的包含根据本发明的一种或多种抗体的药物组合物。
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公开(公告)号：US09540446B2
公开(公告)日：2017-01-10
申请号：US13814510
申请日：2011-08-05
申请人： Michael Bachmann
发明人： Michael Bachmann
CPC分类号： C07K16/30 , C07K16/18 , C07K16/2809 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/54 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/73
摘要： The invention relates to antibodies against the human La protein and to their use in immunotargeting, in particular the immunotargeting of tumor cells. The object of the invention is to provide improved antibodies which bind universal target structures on the surface of tumor cells, and to provide novel anti-La antibodies, in particular with a high affinity for La, a universal target structure on tumor cells, which make it possible to use the antibodies as recombinant fragments for immunotargeting. The invention comprises recombinant antibodies comprising: i. a binding unit of an antibody which specifically binds to an epitope of a human nuclear antigen, preferably human La protein, and ii. a binding unit of an antibody which specifically binds to an effector cell or of a ligand which specifically binds to an effector cell. The invention furthermore comprises novel antibodies which specifically bind the human La protein.
摘要翻译： 本发明涉及抗人类La蛋白的抗体及其在免疫靶向中的用途，特别是肿瘤细胞的免疫靶向。 本发明的目的是提供改进的抗体，其结合肿瘤细胞表面上的通用靶结构，并提供新的抗-La抗体，特别是对La的肿瘤细胞上的通用靶结构具有高亲和力，其使得 可以将抗体用作免疫靶向的重组片段。 本发明包括重组抗体，其包含： 特异性结合人核抗原，优选人La蛋白的表位的抗体的结合单元，和ii。 特异性结合效应细胞或特异性结合效应细胞的配体的抗体的结合单元。 本发明还包括与人La蛋白特异性结合的新型抗体。
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公开(公告)号：US08938346B2
公开(公告)日：2015-01-20
申请号：US13818732
申请日：2011-08-30
申请人： Raphael Oliveira , Michael Bachmann
发明人： Raphael Oliveira , Michael Bachmann
IPC分类号： B60T7/12
CPC分类号： B60T7/12 , B60T7/122 , B60T2201/06
摘要： A method for holding a vehicle at a standstill includes a first phase in which the brake pressure at the wheel brakes is retained so that the vehicle is held automatically by the service brake, and the braking force is then transferred to a parking brake so that in a second phase the vehicle is held solely by the parking brake. A risk inherent in this transfer is that the vehicle may begin to slip. The distance over which the vehicle slides in uncontrolled fashion can be made substantially shorter if, in the second phase in which the vehicle is being held by the parking brake, the movement of the vehicle is monitored by sensors, and brake pressure is automatically built up by way of an actuator as soon as the fact that the vehicle is rolling away has been detected.
摘要翻译： 用于将车辆保持在停止状态的方法包括第一阶段，其中保持车轮制动器处的制动压力，使得车辆被行车制动器自动保持，然后制动力被传递到驻车制动器，使得在 车辆仅由驻车制动器保持的第二阶段。 这种转移固有的风险是车辆可能开始滑落。 如果车辆由驻车制动器保持的第二阶段中车辆的运动由传感器监控，则车辆以不受控制的方式滑动的距离可以大大缩短，并且制动压力被自动建立 一旦检测到车辆正在滚动的事实，就通过致动器。
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公开(公告)号：USD719712S1
公开(公告)日：2014-12-16
申请号：US29431444
申请日：2012-09-07
申请人： Alfred Widmer , Mehmet Avci , Axel Schmitz , Andrew M. Bober , Michael Bachmann , Andreas Staub , Markus Zbinden
设计人： Alfred Widmer , Mehmet Avci , Axel Schmitz , Andrew M. Bober , Michael Bachmann , Andreas Staub , Markus Zbinden
CPC分类号： A46B17/00 , A46B2200/00 , A46B2200/30 , A46B2200/3033
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9.发明申请ANTI-CD33 ANTIBODIES AND USE THEREOF FOR IMMUNOTARGETING IN TREATING CD33-ASSOCIATED ILLNESSES 有权抗CD33抗体及其在治疗CD33相关ILL中的免疫功能公开(公告)号：US20120251554A1
公开(公告)日：2012-10-04
申请号：US13497800
申请日：2010-09-22
申请人： Michael Bachmann , Slava Stamova
发明人： Michael Bachmann , Slava Stamova
IPC分类号： A61K39/395 , C12N9/96 , C12N15/13 , C12N15/63 , A01K67/027 , C12P21/02 , C12N1/19 , C12N5/10 , A01H5/00 , A01K67/033 , C07K16/28 , C12N1/21
CPC分类号： C07K16/2803 , C07K16/2809 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/626
摘要： The invention relates to antibodies to the tumor-associated antigen CD33 and to the use thereof for immunotargeting CD33-positive cells. The antibodies according to the invention are suitable for use in the field of medicine, pharmaceuticals, and biomedical research. According to the invention, the aim is achieved by means of novel anti-CD33 antibodies comprising the complementary determining regions (CDRs) defined in the claim. The antibodies according to the invention are characterized by a high affinity for human CD33, of the order of magnitude of 1010 mol/l. The CDR sequences according to the invention are suitable in particular for producing recombinant fragments (such as scFv fragments or bispecific antibodies) and for immunotargeting, due to the high affinity thereof. The invention further relates to the use of an antibody according to the invention for producing a medication for therapeutic and/or diagnostic application for illnesses associated with the expression of CD33, particularly for acute myeloid leukemia (AML). The invention thus also comprises a pharmaceutical composition comprising one or more antibodies according to the invention in association with a pharmaceutically acceptable thinning agent or carrier.
摘要翻译： 本发明涉及肿瘤相关抗原CD33的抗体及其用于免疫靶向CD33阳性细胞的用途。 根据本发明的抗体适用于医药，药物和生物医学研究领域。 根据本发明，目的是通过包含权利要求中定义的互补决定区（CDR）的新型抗CD33抗体来实现。 根据本发明的抗体的特征在于对人CD33的高亲和力，其数量级为1010mol / l。 由于其高亲和力，根据本发明的CDR序列特别适用于产生重组片段（例如scFv片段或双特异性抗体）和免疫靶向。 本发明还涉及根据本发明的抗体用于产生用于与CD33表达相关的疾病的治疗和/或诊断应用的药物的用途，特别是用于急性骨髓性白血病（AML）。 因此，本发明还包含与药学上可接受的稀释剂或载体结合的包含根据本发明的一种或多种抗体的药物组合物。
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10.发明授权Antibodies against 6-sulfo-LacNac-positive human dendritic cells, and their use 有权针对6-磺基-LacNac阳性人树突状细胞的抗体及其用途公开(公告)号：US09487585B2
公开(公告)日：2016-11-08
申请号：US13814512
申请日：2011-08-05
申请人： Michael Bachmann , Daniel Gräfe
发明人： Michael Bachmann , Daniel Gräfe
CPC分类号： C07K16/28 , A61K9/0019 , A61K38/10 , A61K39/0011 , A61K39/39533 , A61K39/3955 , C07K16/2896 , C07K2317/31 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/92
摘要： The invention relates to a composition which contains at least one anti-slan antibody and to its diagnostic and therapeutic use. The composition according to the invention comprises: a) at least one anti-slan antibody, b) at least one binding unit which binds to a co-stimulus binding to a co-stimulus-specific receptor on dendritic cells, thereby bringing about the modulation, preferably the activation, of said dendritic cells, and c) at least one antigen. The invention furthermore comprises anti-slan antibodies which include CDRs with the following sequences: variable region of the heavy chain: CDR1 (SEQ ID No. 1), CDR2 (SEQ ID No. 2), where Xaa is selected from among M, L, F, or I, preferably from among M or I, CDR3 (SEQ ID No. 5) and variable region of the light chain: CDR1 (SEQ ID No. 6), where Xaa is selected from among S, T, N, Q, H, K or R, preferably from among S or N, CDR2 (SEQ ID No. 9) and CDR3 (SEQ ID No. 10).
摘要翻译： 本发明涉及含有至少一种抗唾液酸抗体及其诊断和治疗用途的组合物。 根据本发明的组合物包含：a）至少一种抗蝙蝠抗体，b）至少一个结合单元，其结合共刺激与树突状细胞上的共刺激特异性受体的结合，由此引起调节 ，优选活化所述树突状细胞，和c）至少一种抗原。 本发明还包括抗an抗体，其包括具有以下序列的CDR：重链可变区：CDR1（SEQ ID No.1），CDR2（SEQ ID No.2），其中Xaa选自M，L ，F或I，优选M或I，CDR3（SEQ ID No.5）和轻链可变区：CDR1（SEQ ID No.6），其中Xaa选自S，T，N， Q，H，K或R，优选来自S或N，CDR2（SEQ ID No.9）和CDR3（SEQ ID No.10）。
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