公开(公告)号：US06172746B2

公开(公告)日：2001-01-09

申请号：US09429123

申请日：1999-10-27

申请人： Michael J. Byrne ,  Thomas E. Ryan ,  Kyle R. Bleyle ,  Keshav D. Sharma ,  Robert C. Atkinson ,  David J. Cash

发明人： Michael J. Byrne ,  Thomas E. Ryan ,  Kyle R. Bleyle ,  Keshav D. Sharma ,  Robert C. Atkinson ,  David J. Cash

IPC分类号： G01N2141

CPC分类号： G01N21/4133

摘要： A transmitted light refractometer comprises an optical system having a movable mirror for redirecting light transmitted through a light-refracting sample to a beam splitter for dividing the light between first and second detection paths. The first detection path leads to an eyepiece whereby an operator may view an illumination boundary shadowline brought into the field of view of the eyepiece by adjusting the position of the movable mirror. The second detection path leads to a light-sensitive detector, preferably a linear scanned array, for generating signal information indicative of the location of the shadowline on the detector. An optical position sensor associated with the movable mirror includes a position detector providing signal information indicative of the position of the movable mirror. During a reading, the shadowline is brought into the field of view of the eyepiece, and the shadowline signal information and the mirror position signal information are processed to calculate index of refraction of the sample.

摘要翻译： 透射光折射计包括具有可移动镜的光学系统，用于将透过光折射样品的光重定向到在第一和第二检测路径之间划分光的分束器。 第一检测路径通向目镜，由此操作者可以通过调节可移动反射镜的位置来观看被带入目镜视场的照明边界阴影线。 第二检测路径通过光敏检测器，优选地是线性扫描阵列，用于产生指示检测器上阴影线位置的信号信息。 与可移动镜相关联的光学位置传感器包括位置检测器，其提供指示可移动镜的位置的信号信息。 在读取期间，阴影线被带入目镜的视野中，并且处理阴影线信号信息和镜像位置信号信息以计算样本的折射率。

公开(公告)号：US06734956B2

公开(公告)日：2004-05-11

申请号：US10139577

申请日：2002-05-06

申请人： Michael J. Byrne ,  Keshav D. Sharma ,  Robert C. Atkinson ,  Bruce R. Cordier

发明人： Michael J. Byrne ,  Keshav D. Sharma ,  Robert C. Atkinson ,  Bruce R. Cordier

IPC分类号： G01N2141

CPC分类号： G01N21/4133

摘要： An optical configuration for measuring a difference in refractive index between a first sample and a second sample comprises partitioned first and second optical interfaces symmetrically illuminated by an illumination beam to provide first and second partial beams defined by the refractive index of the first and second samples, respectively. A linear scanned array is aligned in a meridional plane of the optical configuration for detection purposes, and an optical multiplexor is provided upstream of the linear scanned array for receiving the first and second partial beams and defining first and second optical channels carrying optical signal information corresponding to the first and second partial beams. The optical multiplexor switches between optical channels, such that the linear scanned array detects either the first or second optical channel at a given time. Thus, differential measurements are possible using a single linear array. Embodiments for critical angle and surface plasmon resonance refractive index measurements are disclosed. The disclosure also relates to methods for measuring a difference in refractive index between a first sample and a second sample in accordance with the described optical configuration embodiments.

摘要翻译： 用于测量第一样品和第二样品之间的折射率差异的光学配置包括由照明光束对称地照射的划分的第一和第二光学界面，以提供由第一和第二样品的折射率限定的第一和第二部分光束， 分别。 线性扫描阵列在光学配置的子午平面中对准以用于检测目的，并且在线性扫描阵列的上游提供光学多路复用器，用于接收第一和第二部分波束，并且定义携带相应的光信号信息的第一和第二光学通道 到第一和第二部分光束。 光学多路复用器在光学通道之间切换，使得线性扫描阵列在给定时间检测第一或第二光学通道。 因此，使用单个线性阵列可以进行差分测量。 公开了用于临界角和表面等离子共振折射率测量的实施例。 本公开还涉及根据所述光学配置实施例测量第一样品和第二样品之间的折射率差的方法。

公开(公告)号：US06816248B2

公开(公告)日：2004-11-09

申请号：US09842463

申请日：2001-04-26

申请人： Keshav D. Sharma ,  Kyle R. Bleyle

发明人： Keshav D. Sharma ,  Kyle R. Bleyle

IPC分类号： G01N2141

CPC分类号： G01N33/143 ,  G01N21/43 ,  G01N33/30 ,  G01N2201/0221

摘要： A hand-held automatic refractometer comprises a linear scanned array having a plurality of photoelectric cells and an optical system for directing light onto the array, the particular photoelectric cells of the array which are illuminated by said light being determined by the index of refraction of a sample substance placed on a sample surface of a prism of the optical system. A reflective surface is arranged close to the array at an acute angle thereto for directing primary light from the sample-prism boundary to the array, and for redirecting stray reflected light from the array back onto the array. The disclosed refractometer has a compact design wherein the linear array extends in a direction substantially parallel to the prism sample surface. The prism is mounted in a housing and the sample surface faces upward to allow access through a sample well of the housing, while the array is mounted in the housing facing in a downward direction.

公开(公告)号：US06914728B2

公开(公告)日：2005-07-05

申请号：US10313721

申请日：2002-12-05

申请人： Keshav D. Sharma

发明人： Keshav D. Sharma

IPC分类号： G02B9/34 ,  G02B21/02 ,  G02B3/00 ,  G02B9/00

CPC分类号： G02B9/34 ,  G02B21/02

摘要： This invention relates to a microscope having an infinity-corrected objective and providing a flat field of view. The present invention is an optical arrangement that broadly comprises a first lens element having positive power and comprising at least one lens, a second lens element having negative power and comprising at least one lens, a third lens element having positive power and comprising at least one lens, a fourth lens element having positive power and comprising at least one lens, and a fifth lens element comprising at least one lens and having positive power, and, in addition comprising a configuration in which the radius of curvature of the surface of the fifth lens element proximate to the object plane is less than the radius of curvature of the surface of the fifth lens element distal to the object plane, with the optical arrangement arrayed such that the distance from the first lens element to the second lens element is sufficient to reduce a ray height of a light ray entering the second lens element from the ray height of the same light ray entering said first lens element.

摘要翻译： 本发明涉及具有无穷远校正物镜并提供平坦视场的显微镜。 本发明是一种光学装置，其广泛地包括具有正功率的第一透镜元件，并且包括至少一个透镜，具有负光焦度并包括至少一个透镜的第二透镜元件，具有正光焦度的第三透镜元件，并且包括至少一个透镜 透镜，具有正功率并且包括至少一个透镜的第四透镜元件和包括至少一个透镜并具有正光焦度的第五透镜元件，并且还包括其中第五透镜的表面的曲率半径 靠近物平面的透镜元件小于远离物面的第五透镜元件的表面的曲率半径，其中光学排列使得从第一透镜元件到第二透镜元件的距离足以 从进入所述第一透镜元件的相同光线的射线高度减小进入第二透镜元件的光线的射线高度。

公开(公告)号：US06882481B2

公开(公告)日：2005-04-19

申请号：US10614638

申请日：2003-07-07

申请人： Keshav D. Sharma

发明人： Keshav D. Sharma

IPC分类号： G02B21/02

CPC分类号： G02B21/02

摘要： An arrangement of lenses for a 100×, oil immersion microscope objective is presented. The new configuration gives a flat field of view with diffraction limited performance over all the field. The new optical arrangement broadly includes eight lens elements including a positive power seventh lens element with the radius of curvature of the surface proximate to the object plane less than or approximately equal to the radius of curvature of the surface distal to the object plane, with the optical arrangement arrayed such that the distance from the first lens element to the second lens element is sufficient to reduce a ray height of a light ray and, in addition, arrayed such that the distance from the fifth lens element to the sixth lens element is sufficient to increase the ray height of the light ray entering the sixth lens element from the ray height of the light ray entering the first lens element.

摘要翻译： 介绍了一种用于100x油浸式显微镜物镜的透镜布置。 新的配置给出了在所有领域的衍射受限性能的平坦视场。 新的光学布置广泛地包括八个透镜元件，其包括正功率第七透镜元件，其具有靠近物平面的表面的曲率半径小于或近似等于远离物平面的表面的曲率半径，其中 光学布置排列成使得从第一透镜元件到第二透镜元件的距离足以减小光线的射线高度，并且另外排列成使得从第五透镜元件到第六透镜元件的距离是足够的 从进入第一透镜元件的光线的射线高度增加进入第六透镜元件的光线的射线高度。