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117 条记录 (耗时 0.03 秒)

    Poly(ADP-ribose) polymerase-gene
    1.
    发明授权
    Poly(ADP-ribose) polymerase-gene 失效
    聚（ADP-核糖）聚合酶基因

    公开(公告)号：US07754459B1

    公开(公告)日：2010-07-13

    申请号：US09701586

    申请日：1999-06-04

    申请人： Michael Kock ,  Thomas Höger ,  Burkhard Kröger ,  Bernd Otterbach ,  Wilfried Lubisch ,  Hans-Georg Lemaire

    发明人： Michael Kock ,  Thomas Höger ,  Burkhard Kröger ,  Bernd Otterbach ,  Wilfried Lubisch ,  Hans-Georg Lemaire

    IPC分类号： C12N9/12

    CPC分类号： C12N9/1077 ,  A01K2217/05 ,  A61K38/00 ,  A61K49/00 ,  C07K16/40 ,  C07K2317/76 ,  C07K2319/00 ,  C12Q1/48 ,  C12Y204/0203 ,  G01N2333/91142

    摘要： The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has a) a functional NAD+ binding domain and b) no zinc finger sequence motif of the general formula CX2CXmHX2C  in which  m is an integral value from 28 or 30, and the X radicals are, independently of one another, any amino acid; and the functional equivalents thereof; nucleic acids coding therefor; antibodies with specificity for the novel protein; pharmaceutical and gene therapy compositions which comprise products according to the invention; methods for the analytical determination of the proteins and nucleic acids according to the invention; methods for identifying effectors or binding partners of the proteins according to the invention; novel PARP effectors; and methods for determining the activity of such effectors.

    摘要翻译： 本发明涉及具有氨基酸序列的聚（ADP-核糖）聚合酶（PARP）同系物，该氨基酸序列具有a）功能性的NAD +结合域，b）没有通式CX2CXmHX2C的锌指序列基序，其中m是整数值 28或30个，X基彼此独立地为任何氨基酸; 及其功能等同物; 为此编码的核酸; 对新蛋白具有特异性的抗体; 包括根据本发明的产品的药物和基因治疗组合物; 根据本发明的用于分析测定蛋白质和核酸的方法; 用于鉴定根据本发明的蛋白质的效应物或结合配偶体的方法; 新型PARP效应器; 以及用于确定这种效应物的活性的方法。

    Poly(ADP-ribose) polymerase genes
    2.
    发明授权
    Poly(ADP-ribose) polymerase genes 有权
    聚（ADP-核糖）聚合酶基因

    公开(公告)号：US09051553B2

    公开(公告)日：2015-06-09

    申请号：US12778692

    申请日：2010-05-12

    申请人： Michael Kock ,  Thomas Höger ,  Burkhard Kröger ,  Bernd Otterbach ,  Wilfried Lubisch ,  Hans-Georg Lemaire

    发明人： Michael Kock ,  Thomas Höger ,  Burkhard Kröger ,  Bernd Otterbach ,  Wilfried Lubisch ,  Hans-Georg Lemaire

    IPC分类号： C12N1/20 ,  C12N9/10 ,  A61K38/00 ,  A61K49/00

    CPC分类号： C12N9/1077 ,  A01K2217/05 ,  A61K38/00 ,  A61K49/00 ,  C07K16/40 ,  C07K2317/76 ,  C07K2319/00 ,  C12Q1/48 ,  C12Y204/0203 ,  G01N2333/91142

    摘要： The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has a) a functional NAD binding domain and b) no zinc finger sequence motif of the general formula CX2CXmHX2C in which m is an integral value from 28 or 30, and the X radicals are, independently of one another, any amino acid; and the functional equivalents thereof; nucleic acids coding therefor; antibodies with specificity for the novel protein; pharmaceutical and gene therapy compositions which comprise products according to the invention; methods for the analytical determination of the proteins and nucleic acids according to the invention; methods for identifying effectors or binding partners of the proteins according to the invention; novel PARP effectors; and methods for determining the activity of such effectors.

    摘要翻译： 本发明涉及具有氨基酸序列的聚（ADP-核糖）聚合酶（PARP）同系物，该氨基酸序列具有a）功能性NAD结合域，b）没有通式CX2CXmHX2C的锌指序列基序，其中m是整数值 28或30个，X基彼此独立地为任何氨基酸; 及其功能等同物; 为此编码的核酸; 对新蛋白具有特异性的抗体; 包括根据本发明的产品的药物和基因治疗组合物; 根据本发明的用于分析测定蛋白质和核酸的方法; 用于鉴定根据本发明的蛋白质的效应物或结合配偶体的方法; 新型PARP效应器; 以及用于确定这种效应物的活性的方法。

    2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof
    4.
    发明授权
    2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof 有权
    2-苯基苯并咪唑和2-苯基吲哚，以及其生产和使用

    公开(公告)号：US06509365B1

    公开(公告)日：2003-01-21

    申请号：US09856036

    申请日：2001-05-17

    申请人： Wilfried Lubisch ,  Michael Kock ,  Thomas Höger

    发明人： Wilfried Lubisch ,  Michael Kock ,  Thomas Höger

    IPC分类号： C07D23504

    CPC分类号： C07D209/14 ,  A61K31/404 ,  A61K31/4184 ,  C07D235/18

    摘要： 2-Phenylbenzimidazoles and 2-phenylindoles of formula I wherein A is N or CH, R1 is hydrogen or alkyl which optionally carries an OR11 group, R11 is hydrogen or alkyl, R2 is hydrogen, chlorine, fluorine, bromine, iodine, alkyl, nitro, CF3, CN, NR21R22, NH—CO—R23, OR21, R21 and R22 are each hydrogen or alkyl, R23 is hydrogen, alkyl or phenyl, R3 is —(CH2)q—NR31R32, q is 0, 1, 2 or 3, R31 is hydrogen, alkyl, (CH2)rNR33R34, R32 is (CH2)rNR33R34, r is 2, 3, 4, 5 or 6, R33 and R34 are each hydrogen, alkyl or phenylalkyl wherein the phenyl ring is optionally substituted, or R33 and R34 and the nitrogen atom form a 3- to 8-membered ring, R4 is hydrogen, alkyl, chlorine, bromine, fluorine, nitro, cyano, NR41R42, NH—CO—R43, OR41, R41 and R42 are each hydrogen or alkyl, and R43 is alkyl or phenyl, are useful as inhibitors of poly(ADP-ribose)polymerase and for the production of drugs.

    摘要翻译： 式I的2-苯基苯并咪唑和2-苯基吲哚，其中A是N或CH，R 1是氢或任选地带有OR 11基团的烷基，R 11是氢或烷基，R 2是氢，氯，氟，溴，碘，烷基，硝基，CF 3 ，CN，NR21R22，NH-CO-R23，OR21，R21和R22各自为氢或烷基，R23为氢，烷基或苯基，R3为 - （CH2）q-NR31R32，q为0,1,2或3， R31是氢，烷基，（CH2）rNR33R34，R32是（CH2）rNR33R34，r是2,3,4,5或6，R33和R34各自是氢，烷基或苯基烷基，其中苯环是任选取代的，或R 33和 R34和氮原子形成3-至8-元环，R4为氢，烷基，氯，溴，氟，硝基，氰基，NR41R42，NH-CO-R43，OR41，R41和R42各自为氢或烷基， 和R43是烷基或苯基，可用作聚（ADP-核糖）聚合酶的抑制剂和用于生产药物。