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    Substituted pyridoindoles as serotonin agonists and antagonists
    5.
    发明授权
    Substituted pyridoindoles as serotonin agonists and antagonists 有权
    取代的吡啶并吲哚作为血清素激动剂和拮抗剂

    公开(公告)号：US06699852B2

    公开(公告)日：2004-03-02

    申请号：US10026611

    申请日：2001-12-19

    申请人： Albert Robichaud ,  John M. Fevig ,  Ian S. Mitchell ,  Taekyu Lee ,  Wenting Chen ,  Joseph Cacciola

    发明人： Albert Robichaud ,  John M. Fevig ,  Ian S. Mitchell ,  Taekyu Lee ,  Wenting Chen ,  Joseph Cacciola

    IPC分类号： A61K3133

    CPC分类号： C07D471/16 ,  C07D498/16 ,  C07D513/16

    摘要： The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6, R7, R8, R9, X, b, k, and n, and the dashed lines are described herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including obesity, anxiety, depression, psychosis, schizophrenia, sleep disorders, sexual disorders, migraine, conditions associated with cephalic pain, social phobias, and gastrointestinal disorders such as dysfunction of the gastrointestinal tract motility.

    摘要翻译： 本发明涉及由结构式（I）表示的某些新化合物或其药学上可接受的盐形式，其中R 1，R 5，R 6，R 7，R 8，R <9>，X，b，k和n，这里描述虚线。 本发明还涉及包含这些新化合物作为活性成分的药物制剂，以及新型化合物及其制剂在治疗某些疾病中的用途。 本发明的化合物是血清素激动剂和拮抗剂，可用于控制或预防中枢神经系统疾病，包括肥胖症，焦虑症，抑郁症，精神病，精神分裂症，睡眠障碍，性障碍，偏头痛，与头痛相关的病症，社交恐怖症 ，以及胃肠道疾病如胃肠道运动功能障碍。

    Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists
    7.
    发明申请
    Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists 有权
    取代的六氢 - 吡啶并吲哚衍生物作为血清素受体激动剂和拮抗剂

    公开(公告)号：US20050239768A1

    公开(公告)日：2005-10-27

    申请号：US11104933

    申请日：2005-04-13

    申请人： Taekyu Lee ,  Wei Deng ,  Albert Robichaud

    发明人： Taekyu Lee ,  Wei Deng ,  Albert Robichaud

    IPC分类号： A61K31/435 ,  A61K31/437 ,  A61K31/4745 ,  A61K31/55 ,  A61P3/04 ,  A61P25/00 ,  C07D471/02 ,  C07D471/04 ,  C07D487/02 ,  C07D487/04

    CPC分类号： C07D471/04

    摘要： The present application provides novel compounds according to Formula (I): including all stereoisomers, solvates, prodrug esters and pharmaceutically acceptable salt forms thereof, wherein R1, R4a, R5, R6, R7, R8, R9, m, and X are described herein. Additionally, the present application provides novel pharmaceutical compositions comprising at least one compound according to Formula (I). Further, the present application provides methods of treating a patient in need comprising administering a therapeutically effective amount of at least one compound according to Formula (I).

    摘要翻译： 本申请提供了根据式（I）的新化合物：包括所有立体异构体，溶剂合物，前药酯及其药学上可接受的盐形式，其中R 1，R 4，R 4，R R 5，R 6，R 7，R 8，R 9，M 9， ，和X。 另外，本申请提供了包含至少一种根据式（I）的化合物的新型药物组合物。 此外，本申请提供了治疗需要的患者的方法，其包括施用治疗有效量的至少一种根据式（I）的化合物。