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    Headwear With Improved Temple Openings
    4.
    发明申请
    Headwear With Improved Temple Openings 有权

    公开(公告)号：US20220346483A1

    公开(公告)日：2022-11-03

    申请号：US17412172

    申请日：2021-08-25

    申请人： John McDonald ,  Cynthia McDonald

    发明人： John McDonald ,  Cynthia McDonald

    IPC分类号： A42B1/247 ,  A42B1/241 ,  A42B1/041

    摘要： The present specification discloses headwear configured to permit the user to easily don an item of eyewear, such as prescription glasses, reading glasses, sun glasses, safety glasses, and the like. The present headwear provides a unique pocket design on each side with an eyewear temple aperture located within the pockets. The pockets are created by forming a z-folded configuration out of a fabric panel for each pocket and tacking the three layers of material together, above and below the eyewear temple aperture. Each of the pockets are positioned forward of at least part of the ears, and open towards the user's anterior. The outermost panel of each of the pockets protrudes from the sides of the headwear to provide sufficient clearance for the temples of the eyewear to easily slip into the pockets and through the eyewear temple apertures.

    Nanogels for cellular delivery of therapeutics
    6.
    发明授权
    Nanogels for cellular delivery of therapeutics 有权
    用于细胞递送治疗剂的纳米凝胶

    公开(公告)号：US08361510B2

    公开(公告)日：2013-01-29

    申请号：US12997983

    申请日：2009-06-16

    申请人： Louis Andrew Lyon ,  John McDonald ,  Erin Beth Dickerson ,  William Hobart Blackburn

    发明人： Louis Andrew Lyon ,  John McDonald ,  Erin Beth Dickerson ,  William Hobart Blackburn

    IPC分类号： A61K9/51 ,  A61K38/04 ,  C12N15/11 ,  C07H21/02

    CPC分类号： A61K31/70 ,  A61K9/5138

    摘要： The various embodiments of the present disclosure relate generally to nanogels for the cellular delivery of therapeutics and methods of using the same. More particularly, the various embodiments of the present invention are directed to systems and methods for the targeted treatment of neoplastic using nanogel-based technologies. In an embodiment of the present invention, a nanogel-based delivery system comprises: a nanogel comprising a crosslinked polymer particle; and an active agent contained substantially within the nanogel, wherein the active agent is non-covalently associated with the nanogel.

    摘要翻译： 本公开的各种实施方案通常涉及用于细胞递送治疗剂的纳米凝胶及其使用方法。 更具体地，本发明的各种实施方案涉及使用基于纳米凝胶的技术靶向治疗肿瘤的系统和方法。 在本发明的一个实施方案中，基于纳米凝胶的递送系统包括：包含交联聚合物颗粒的纳米凝胶; 和基本上含有纳米凝胶的活性剂，其中活性剂与纳米凝胶非共价结合。

    SUSPENSION PACKAGING SYSTEM
    7.
    发明申请
    SUSPENSION PACKAGING SYSTEM 有权
    悬挂包装系统

    公开(公告)号：US20120292380A1

    公开(公告)日：2012-11-22

    申请号：US13472394

    申请日：2012-05-15

    申请人： John McDonald ,  Frank Comerford ,  Myles Comerford

    发明人： John McDonald ,  Frank Comerford ,  Myles Comerford

    IPC分类号： B65D5/42 ,  B65D25/54 ,  B65D5/4805 ,  B65D5/66 ,  B65B5/02 ,  B65B23/00

    CPC分类号： B65D81/07 ,  B65D5/5021 ,  B65D5/5028

    摘要： A suspension packaging system can include a foldable member configured to form a cavity as well as a suspension device for suspending an article to be packaged within the cavity. The suspension portion can include foldable portions configured to cooperate with a retention member having pockets. The foldable portions can fit into the pockets and then be folded so as to generate tension in the retention member. The entire device, with the exception of the retention member, can be made from a single piece of material, such as corrugated cardboard, which thus reduces waste and simplifies bulk distribution of such a suspension packaging system.

    摘要翻译： 悬挂包装系统可以包括构造成形成空腔的可折叠构件以及用于悬挂待包装物品在空腔内的悬挂装置。 悬挂部分可以包括被配置为与具有口袋的保持构件配合的可折叠部分。 可折叠部分可以装配到袋中，然后被折叠以便在保持构件中产生张力。 除了保持构件之外，整个装置可以由单件材料制成，例如瓦楞纸板，从而减少浪费并简化这种悬挂包装系统的散装。

    SUSPENSION PACKAGING ASSEMBLY
    8.
    发明申请
    SUSPENSION PACKAGING ASSEMBLY 有权
    悬挂包装总成

    公开(公告)号：US20120272620A1

    公开(公告)日：2012-11-01

    申请号：US13405103

    申请日：2012-02-24

    申请人： John McDonald ,  Myles Comerford ,  Frank Comerford

    发明人： John McDonald ,  Myles Comerford ,  Frank Comerford

    IPC分类号： B65D81/07 ,  B65B43/00

    CPC分类号： B65D81/075 ,  B65D5/5028

    摘要： A packaging assembly includes a frame member and a retention member which is not permanently affixed to the frame member. The frame member can include a variety of features which allow the retention member to be tightened around an article to be packaged and thus protected from shocks and impacts during transport, display, and/or retail use. The retention member can be formed as a sleeve or with pockets for engaging the frame member.

    摘要翻译： 包装组件包括框架构件和不永久地固定到框架构件的保持构件。 框架构件可以包括各种特征，其允许保持构件围绕要包装的物品紧固，并且因此在运输，显示和/或零售使用期间防止冲击和冲击。 保持构件可以形成为套筒或用于与框架构件接合的袋。

    Suspension packaging assembly
    9.
    发明授权
    Suspension packaging assembly 有权
    悬挂包装组件

    公开(公告)号：US08235216B2

    公开(公告)日：2012-08-07

    申请号：US11633712

    申请日：2006-12-05

    申请人： John McDonald ,  Frank Comerford ,  Myles Comerford

    发明人： John McDonald ,  Frank Comerford ,  Myles Comerford

    IPC分类号： B65D81/02

    CPC分类号： B65D81/022 ,  B65B5/04 ,  B65D5/5028 ,  B65D81/05 ,  B65D2585/6842

    摘要： A suspension package assembly can include a package member and a stretchable retention member. The package member and a stretchable retention member cooperate to suspend at least one article. At least one article can be held securely between the retention member and a base member of the foldable member. The pocket of the retention member can be positioned over the foldable portions of the package member. The foldable portions can fit into the pockets and then can be folded so as to generate tension in the retention member. Coupling assemblies inhibit relative movement of the retention member and the packaging member.

    摘要翻译： 悬挂包装组件可以包括包装件和可拉伸保持件。 包装构件和可拉伸的保持构件配合以悬挂至少一个物品。 至少一个物品可以牢固地保持在保持构件和可折叠构件的基部构件之间。 保持构件的凹部可以定位在包装构件的可折叠部分上方。 可折叠部分可以装配到袋中，然后可以折叠以便在保持构件中产生张力。 联接组件阻止保持构件和包装构件的相对移动。

    METABOLIC BIOMARKERS FOR OVARIAN CANCER AND METHODS OF USE THEREOF
    10.
    发明申请
    METABOLIC BIOMARKERS FOR OVARIAN CANCER AND METHODS OF USE THEREOF 审中-公开
    用于卵巢癌的代谢生物标记物及其使用方法

    公开(公告)号：US20120004854A1

    公开(公告)日：2012-01-05

    申请号：US12994310

    申请日：2009-05-28

    申请人： Facundo M. Fernandez ,  Manshui Zhou ,  John McDonald ,  Alexander Gray ,  Wei Guan

    发明人： Facundo M. Fernandez ,  Manshui Zhou ,  John McDonald ,  Alexander Gray ,  Wei Guan

    IPC分类号： G06F19/00 ,  G01N24/00 ,  G01N33/574

    CPC分类号： G16H50/20 ,  G01N33/57449 ,  G01N2800/52 ,  G16B20/00 ,  G16B40/00

    摘要： Panels of serum metabolic biomarkers and methods of their use in detecting and diagnosing cancer, especially ovarian cancer, are disclosed. The metabolic biomarker panels include 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 50, 75, 100, 150, or more metabolites. Supervised classification methods, such as trained support vector machines (SVMs) are used to determine whether the levels of metabolic biomarkers in a subject are indicative of the presence of cancer. The disclosed biomarkers and methods preferably allow a diagnosis of cancer with an accuracy, a specificity, and/or a sensitivity of at least 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99%.

    摘要翻译： 公开了血清代谢生物标记物及其在检测和诊断癌症中尤其是卵巢癌中的用途。 代谢生物标志物组包括2,3,4,5,6,7,8,9,10,15,20,25,50,75,100,150或更多的代谢物。 使用经过训练的支持向量机（SVM）的监督分类方法来确定受试者的代谢生物标志物的水平是否表明存在癌症。 公开的生物标志物和方法优选允许以至少80％，85％，90％，95％，96％，97％，98％或99％的准确度，特异性和/或敏感性诊断癌症。