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公开(公告)号：US5910414A
公开(公告)日：1999-06-08
申请号：US949637
申请日：1997-10-14
申请人： Michael N. Gwynn , Howard Kallender
发明人： Michael N. Gwynn , Howard Kallender
IPC分类号： G01N33/50 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/04 , A61P37/00 , C07K16/12 , C12N9/90 , C12N15/00 , C12N15/09 , C12N15/61 , C12P21/08 , C12Q1/533 , C12Q1/68 , C12R1/46 , G01N33/15 , G01N33/569 , G01N33/573 , C07H21/00 , C12N5/10 , C12N15/31
摘要： topoisomerase I polypeptides and DNA and RNA encoding such topoisomerase I polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such topoisomerase I for the treatment of infection, particularly bacterial infections. Antagonists against such topoisomerase I and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of topoisomerase I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding streptococcal topoisomerase I and for detecting the polypeptide in a host.
摘要翻译： 拓扑异构酶I多肽和编码这种拓扑异构酶I多肽的DNA和RNA以及通过重组技术产生此类多肽的方法。 还公开了利用这种拓扑异构酶I来治疗感染，特别是细菌感染的方法。 还公开了抗这种拓扑异构酶I的拮抗剂及其用作治疗感染，特别是细菌感染的治疗剂。 还公开了用于检测与宿主中拓扑异构酶I核酸序列和多肽的存在相关的疾病的诊断测定法。 还公开了用于检测编码链球菌拓扑异构酶I的多核苷酸并用于检测宿主中的多肽的诊断测定。
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公开(公告)号：US06251387B1
公开(公告)日：2001-06-26
申请号：US09291488
申请日：1999-04-14
申请人： Michael N. Gwynn , Howard Kallender
发明人： Michael N. Gwynn , Howard Kallender
IPC分类号： A61K3851
摘要： Topoisomerase I polypeptides and DNA and RNA encoding such topoisomerase I polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such topoisomerase I for the treatment of infection, particularly bacterial infections. Antagonists against such topoisomerase I and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of topoisomerase I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding streptococcal topoisomerase I and for detecting the polypeptide in a host.
摘要翻译： 拓扑异构酶I多肽和编码这种拓扑异构酶I多肽的DNA和RNA以及通过重组技术产生这种多肽的方法被公开。 还公开了利用这种拓扑异构酶I来治疗感染，特别是细菌感染的方法。 还公开了抗这种拓扑异构酶I的拮抗剂及其用作治疗感染，特别是细菌感染的治疗剂。 还公开了用于检测与宿主中拓扑异构酶I核酸序列和多肽的存在相关的疾病的诊断测定法。 还公开了用于检测编码链球菌拓扑异构酶I的多核苷酸并用于检测宿主中的多肽的诊断测定。
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公开(公告)号：US06274139B1
公开(公告)日：2001-08-14
申请号：US09340479
申请日：1999-06-30
IPC分类号： A61K3851
摘要： Topoisomerase I polypeptides and DNA and RNA encoding such Topoisomerase I polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase I for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase I and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Staphylococcal Topoisomerase I and for detecting the polypeptide in a host.
摘要翻译： 公开了拓扑异构酶I多肽和编码这种拓扑异构酶I多肽的DNA和RNA以及通过重组技术产生这种多肽的方法。 还公开了利用这种拓扑异构酶I来治疗感染，特别是细菌感染的方法。 还公开了抗这种拓扑异构酶I的拮抗剂及其用作治疗感染，特别是细菌感染的治疗剂。 还公开了用于检测与宿主中拓扑异构酶I核酸序列和多肽的存在相关的疾病的诊断测定。 还公开了用于检测编码葡萄球菌拓扑异构酶I的多核苷酸并用于检测宿主中的多肽的诊断测定。
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公开(公告)号：US5962303A
公开(公告)日：1999-10-05
申请号：US949584
申请日：1997-10-14
申请人： Michael N. Gwynn , Howard Kallendar
发明人： Michael N. Gwynn , Howard Kallendar
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/04 , A61P37/04 , A61P43/00 , C07K14/315 , C07K16/12 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/90 , C12N15/00 , C12N15/61 , C12P21/08 , C12Q1/533 , C12Q1/68 , C12R1/46 , G01N33/53 , C12N1/00 , C12N15/63
摘要： Topoisomerase III polypeptides and DNA and RNA encoding such Topoisomerase III polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase III for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase III and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase III nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Streptococcal Topoisomerase III and for detecting the polypeptide in a host.
摘要翻译： 拓扑异构酶III多肽和编码这种拓扑异构酶III多肽的DNA和RNA以及通过重组技术产生此类多肽的方法。 还公开了利用这种拓扑异构酶III来治疗感染，特别是细菌感染的方法。 还公开了抗这种拓扑异构酶III的拮抗剂及其用作治疗感染，特别是细菌感染的治疗剂。 还公开了用于检测与宿主中拓扑异构酶III核酸序列和多肽的存在相关的疾病的诊断测定。 还公开了用于检测编码链球菌拓扑异构酶III的多核苷酸并用于检测宿主中的多肽的诊断测定。
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公开(公告)号：US06277620B1
公开(公告)日：2001-08-21
申请号：US09299861
申请日：1999-04-26
申请人： Michael N. Gwynn , Howard Kallendar
发明人： Michael N. Gwynn , Howard Kallendar
IPC分类号： C12N990
摘要： Topoisomerase III polypeptides and DNA and RNA encoding such Topoisomerase III polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase III for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase III and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase III nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Streptococcal Topoisomerase El and for detecting the polypeptide in a host.
摘要翻译： 拓扑异构酶III多肽和编码这种拓扑异构酶III多肽的DNA和RNA以及通过重组技术产生此类多肽的方法。 还公开了利用这种拓扑异构酶III来治疗感染，特别是细菌感染的方法。 还公开了抗这种拓扑异构酶III的拮抗剂及其用作治疗感染，特别是细菌感染的治疗剂。 还公开了用于检测与宿主中拓扑异构酶III核酸序列和多肽的存在相关的疾病的诊断测定。 还公开了用于检测编码链球菌拓扑异构酶E1的多核苷酸并用于检测宿主中的多肽的诊断测定。
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公开(公告)号：US6156310A
公开(公告)日：2000-12-05
申请号：US310669
申请日：1999-05-12
IPC分类号： G01N33/50 , A61K38/00 , A61K38/45 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/04 , C07K16/40 , C12N9/90 , C12N15/00 , C12N15/09 , C12N15/61 , C12Q1/68 , C12R1/445 , G01N33/566 , G01N33/573 , A61K38/51 , C07K1/00
CPC分类号： C12N9/90 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Topoisomerase III polypeptides and DNA and RNA encoding such Topoisomerase III polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase III for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase III and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase III nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Staphylococcal Topoisomerase III and for detecting the polypeptide in a host.
摘要翻译： 拓扑异构酶III多肽和编码这种拓扑异构酶III多肽的DNA和RNA以及通过重组技术产生此类多肽的方法。 还公开了利用这种拓扑异构酶III来治疗感染，特别是细菌感染的方法。 还公开了抗这种拓扑异构酶III的拮抗剂及其用作治疗感染，特别是细菌感染的治疗剂。 还公开了用于检测与宿主中拓扑异构酶III核酸序列和多肽的存在相关的疾病的诊断测定。 还公开了用于检测编码葡萄球菌拓扑异构酶III的多核苷酸并用于检测宿主中的多肽的诊断测定法。
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公开(公告)号：US6025156A
公开(公告)日：2000-02-15
申请号：US949588
申请日：1997-10-14
IPC分类号： G01N33/50 , A61K38/00 , A61K38/45 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/04 , C07K16/40 , C12N9/90 , C12N15/00 , C12N15/09 , C12N15/61 , C12Q1/68 , C12R1/445 , G01N33/566 , G01N33/573 , C07H21/04
CPC分类号： C12N9/90 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Topoisomerase III polypeptides and DNA and RNA encoding such Topoisomerase III polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase III for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase III and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase III nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Staphylococcal Topoisomerase III and for detecting the polypeptide in a host.
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公开(公告)号：US6013505A
公开(公告)日：2000-01-11
申请号：US946475
申请日：1997-10-07
IPC分类号： G01N33/53 , A61K38/00 , A61K38/45 , A61K38/55 , A61K39/00 , A61K48/00 , A61P31/04 , C07K14/81 , C12N5/00 , C12N5/10 , C12N9/90 , C12N15/09 , C12N15/61 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/531 , G01N33/566 , C07H21/04
摘要： Topoisomerase I polypeptides and DNA and RNA encoding such Topoisomerase I polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase I for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase I and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Staphylococcal Topoisomerase I and for detecting the polypeptide in a host.
摘要翻译： 公开了拓扑异构酶I多肽和编码这种拓扑异构酶I多肽的DNA和RNA以及通过重组技术产生这种多肽的方法。 还公开了利用这种拓扑异构酶I来治疗感染，特别是细菌感染的方法。 还公开了抗这种拓扑异构酶I的拮抗剂及其用作治疗感染，特别是细菌感染的治疗剂。 还公开了用于检测与宿主中拓扑异构酶I核酸序列和多肽的存在相关的疾病的诊断测定。 还公开了用于检测编码葡萄球菌拓扑异构酶I的多核苷酸并用于检测宿主中的多肽的诊断测定。
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